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Quantification of cardiac fiber orientation using optical coherence tomography

Christine P. Fleming; Crystal M. Ripplinger; Bryan Webb; Igor R. Efimov; Andrew M. Rollins

Title:
Quantification of cardiac fiber orientation using optical coherence tomography
Author(s):
Fleming, Christine P.
Ripplinger, Crystal M.
Webb, Bryan
Efimov, Igor R.
Rollins, Andrew M.
Date:
Type:
Articles
Department:
Electrical Engineering
Volume:
13
Permanent URL:
Book/Journal Title:
Journal of Biomedical Optics
Abstract:
Heterogeneity in cardiac tissue microstructure is a potential mechanism for the generation and maintenance of arrhythmias. Abnormal changes in fiber orientation increase the likelihood of arrhythmia. We present optical coherence tomography (OCT) as a method to image myofibers in excised intact heart preparations. Three-dimensional (3-D) image sets were gathered from the rabbit right ventricular free wall (RVFW) using a microscope-integrated OCT system. An automated algorithm for fiber orientation quantification in the plane parallel to the wall surface was developed. The algorithm was validated by comparison with manual measurements. Quantifying fiber orientation in the plane parallel to the wall surface from OCT images can be used to help understand the conduction system of the specific sample being imaged.
Subject(s):
Medical imaging and radiology
Publisher DOI:
http://dx.doi.org/10.1117/1.2937470
Item views:
240
Metadata:
text | xml

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