Methodological Issues in Clinical Drug Development for Essential Tremor
Michael A. Carranza; Madeline R. Snyder; Rodger J. Elble; Angelique E. Boutzoukas; Theresa A. Zesiewicz
- Methodological Issues in Clinical Drug Development for Essential Tremor
Carranza, Michael A.
Snyder, Madeline R.
Elble, Rodger J.
Boutzoukas, Angelique E.
Zesiewicz, Theresa A.
- Center for Parkinson's Disease and Other Movement Disorders
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- Tremor and Other Hyperkinetic Movements
- Essential tremor (ET) is one of the most common tremor disorders in the world. Despite this, only two medications have received Level A recommendations from the American Academy of Neurology to treat it (primidone and propranolol). Even though these medications provide relief to a large group of ET patients, up to 50% of patients are non-responders. Additional medications to treat ET are needed. This review discusses some of the methodological issues that should be addressed for quality clinical drug development in ET.
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