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Examining the Motor Phenotype of Patients with Both Essential Tremor and Parkinson's Disease

Rita M. Simões; Anne Constantino; Eliza Gibadullina; David Houghton; Elan D. Louis; Irene Litvan

Title:
Examining the Motor Phenotype of Patients with Both Essential Tremor and Parkinson's Disease
Author(s):
Simões, Rita M.
Constantino, Anne
Gibadullina, Eliza
Houghton, David
Louis, Elan D.
Litvan, Irene
Date:
Type:
Articles
Department:
Center for Parkinson's Disease and Other Movement Disorders
Volume:
2
Permanent URL:
Book/Journal Title:
Tremor and Other Hyperkinetic Movements
Abstract:
Background: The subset of patients with essential tremor (ET) that develops Parkinson's disease (PD) has not been fully clinically characterized. Methods: Motor features were retrospectively reviewed in 18 ET patients who developed PD (ET→PD), 20 ET and 30 PD patients with similar ages and disease durations. Results: Fewer ET→PD than ET patients had widespread postural and/or action tremor (2/17 [11.8%] vs. 11/17 [64.7%]; p = 0.001) and marginally fewer had cerebellar signs (1/15 [6.7%] vs. 6/18 [33.3%], p = 0.06). ET→PD patients required fewer ET medications than did their counterparts with ET (p = 0.001). ET→PD patients and PD patients did not differ in UPDRS, Hoehn and Yahr, or Schwab and England scores (each p≥0.14). Discussion: ET patients who develop PD may have distinct pre-PD motor features compared to their counterparts with ET who do not develop co-existing PD. Prospective studies are needed to evaluate the predictive value of these clinical features for the emergence of PD.
Subject(s):
Neurosciences
Item views:
108
Metadata:
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Suggested Citation:
Rita M. Simões, Anne Constantino, Eliza Gibadullina, David Houghton, Elan D. Louis, Irene Litvan, 2012, Examining the Motor Phenotype of Patients with Both Essential Tremor and Parkinson's Disease, Columbia University Academic Commons, http://hdl.handle.net/10022/AC:P:13875.

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