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Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression

Lindi Roberts; Jo-Ann S. Passmore; Carolyn Williamson; Francesca Little; Lisa M. Bebell; Koleka P. Mlisana; Wendy A. Burgers; Francois van Loggerenberg; Gerhard Walzl; Joel F. Djoba Siawaya; Quarraisha Abdool Karim; Salim Abdool Karim

Title:
Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression
Author(s):
Roberts, Lindi
Passmore, Jo-Ann S.
Williamson, Carolyn
Little, Francesca
Bebell, Lisa M.
Mlisana, Koleka P.
Burgers, Wendy A.
Loggerenberg, Francois van
Walzl, Gerhard
Djoba Siawaya, Joel F.
Abdool Karim, Quarraisha
Abdool Karim, Salim
Date:
Type:
Articles
Department:
Epidemiology
Volume:
24
Permanent URL:
Book/Journal Title:
AIDS
Abstract:
BACKGROUND: Both T-cell activation during early HIV-1 infection and soluble markers of immune activation during chronic infection are predictive of HIV disease progression. Although the acute phase of HIV infection is associated with increased pro-inflammatory cytokine production, the relationship between cytokine concentrations and HIV pathogenesis is unknown. OBJECTIVES: To identify cytokine biomarkers measurable in plasma during acute HIV-1 infection that predict HIV disease progression. DESIGN: Study including 40 South African women who became infected with HIV-1 and were followed longitudinally from the time of infection. METHODS: The concentrations of 30 cytokines in plasma from women with acute HIV-1 infection were measured and associations between cytokine levels and both viral load set point 12 months postinfection and time taken for CD4 cell counts to fall below 350 cells/microl were determined using multivariate and Cox proportional hazards regression. RESULTS: We found that the concentrations of five plasma cytokines, IL-12p40, IL-12p70, IFN-gamma, IL-7 and IL-15 in women with acute infection predicted 66% of the variation in viral load set point 12 months postinfection. IL-12p40, IL-12p70 and IFN-gamma were significantly associated with lower viral load, whereas IL-7 and IL-15 were associated with higher viral load. Plasma concentrations of IL-12p40 and granulocyte-macrophage colony-stimulating factor during acute infection were associated with maintenance of CD4 cell counts above 350 cells/microl, whereas IL-1alpha, eotaxin and IL-7 were associated with more rapid CD4 loss. CONCLUSION: A small panel of plasma cytokines during acute HIV-1 infection was predictive of long-term HIV disease prognosis in this group of South African women.
Subject(s):
Virology
Epidemiology
Publisher DOI:
http://dx.doi.org/10.1097/QAD.0b013e3283367836
Item views:
174
Metadata:
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