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Identification of GBV-D, a novel GB-like flavivirus from Old World frugivorous Bats (Pteropus giganteus) in Bangladesh

Jonathan H. Epstein; Phuong-Lan Quan; Thomas Briese; Craig Street; Omar J. Jabado; Sean Conlan; Shahneaz Ali Khan; Dawn Verdugo; M. Jahangir Hossain; Stephen K. Hutchison; Michael Egholm; Stephen P. Luby; Peter Daszak; W. Ian Lipkin

Title:
Identification of GBV-D, a novel GB-like flavivirus from Old World frugivorous Bats (Pteropus giganteus) in Bangladesh
Author(s):
Epstein, Jonathan H.
Quan, Phuong-Lan
Briese, Thomas
Street, Craig
Jabado, Omar J.
Conlan, Sean
Khan, Shahneaz Ali
Verdugo, Dawn
Hossain, M. Jahangir
Hutchison, Stephen K.
Egholm, Michael
Luby, Stephen P.
Daszak, Peter
Lipkin, W. Ian
Date:
Type:
Articles
Department:
Center for Infection and Immunity
Volume:
6
Permanent URL:
Book/Journal Title:
PLoS pathogens
Abstract:
Bats are reservoirs for a wide range of zoonotic agents including lyssa-, henipah-, SARS-like corona-, Marburg-, Ebola-, and astroviruses. In an effort to survey for the presence of other infectious agents, known and unknown, we screened sera from 16 Pteropus giganteus bats from Faridpur, Bangladesh, using high-throughput pyrosequencing. Sequence analyses indicated the presence of a previously undescribed virus that has approximately 50% identity at the amino acid level to GB virus A and C (GBV-A and -C). Viral nucleic acid was present in 5 of 98 sera (5%) from a single colony of free-ranging bats. Infection was not associated with evidence of hepatitis or hepatic dysfunction. Phylogenetic analysis indicates that this first GBV-like flavivirus reported in bats constitutes a distinct species within the Flaviviridae family and is ancestral to the GBV-A and -C virus clades.
Subject(s):
Epidemiology
Virology
Publisher DOI:
10.1371/journal.ppat.1000972
Item views:
213
Metadata:
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