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Identification of GBV-D, a novel GB-like flavivirus from Old World frugivorous Bats (Pteropus giganteus) in Bangladesh

Jonathan H. Epstein; Phuong-Lan Quan; Thomas Briese; Craig Street; Omar J. Jabado; Sean Conlan; Shahneaz Ali Khan; Dawn Verdugo; M. Jahangir Hossain; Stephen K. Hutchison; Michael Egholm; Stephen P. Luby; Peter Daszak; W. Ian Lipkin

Title:
Identification of GBV-D, a novel GB-like flavivirus from Old World frugivorous Bats (Pteropus giganteus) in Bangladesh
Author(s):
Epstein, Jonathan H.; Quan, Phuong-Lan; Briese, Thomas; Street, Craig; Jabado, Omar J.; Conlan, Sean; Khan, Shahneaz Ali; Verdugo, Dawn; Hossain, M. Jahangir; Hutchison, Stephen K.; Egholm, Michael; Luby, Stephen P.; Daszak, Peter; Lipkin, W. Ian
Date:
Type:
Articles
Department:
Center for Infection and Immunity
Volume:
6
Permanent URL:
Book/Journal Title:
PLoS pathogens
Abstract:
Bats are reservoirs for a wide range of zoonotic agents including lyssa-, henipah-, SARS-like corona-, Marburg-, Ebola-, and astroviruses. In an effort to survey for the presence of other infectious agents, known and unknown, we screened sera from 16 Pteropus giganteus bats from Faridpur, Bangladesh, using high-throughput pyrosequencing. Sequence analyses indicated the presence of a previously undescribed virus that has approximately 50% identity at the amino acid level to GB virus A and C (GBV-A and -C). Viral nucleic acid was present in 5 of 98 sera (5%) from a single colony of free-ranging bats. Infection was not associated with evidence of hepatitis or hepatic dysfunction. Phylogenetic analysis indicates that this first GBV-like flavivirus reported in bats constitutes a distinct species within the Flaviviridae family and is ancestral to the GBV-A and -C virus clades.
Subject(s):
Epidemiology, Virology
Publisher DOI:
10.1371/journal.ppat.1000972
Item views:
215
Metadata:
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