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Heat Transfer Model of Hyporthermic Intracarotid Infusion of Cold Saline for Stroke Therapy

Matthew A. Neimark; Angelos-Aristeidis Konstas; Andrew F. Laine; John Pile-Spellman

Title:
Heat Transfer Model of Hyporthermic Intracarotid Infusion of Cold Saline for Stroke Therapy
Author(s):
Neimark, Matthew A.
Konstas, Angelos-Aristeidis
Laine, Andrew F.
Pile-Spellman, John
Date:
Type:
Articles
Department:
Biomedical Engineering
Permanent URL:
Book/Journal Title:
2006 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: New York, NY, 30 August-3 September 2006
Publisher:
IEEE
Publisher Location:
Piscataway, N.J.
Abstract:
A 3-dimensional hemispheric computational brain model is developed to simulate infusion of cold saline in the carotid arteries in terms of brain cooling for stroke therapy. The model is based on the Pennes bioheat equation, with four tissue layers: white matter, gray matter, skull, and scalp. The stroke lesion is simulated by reducing blood flow to a selected volume of the brain by a factor of one-third, and brain metabolism by 50%. A stroke penumbra was also generated surrounding the core lesion (blood volume reduction 25%, metabolism reduction 20%). The finite difference method was employed to solve the system of partial differential equations. This model demonstrated a reduction in brain temperature, at the stroke lesion, to 32°C in less than 10 minutes.
Subject(s):
Biomedical engineering
Publisher DOI:
http://dx.doi.org/10.1109/IEMBS.2006.259435
Item views:
126
Metadata:
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