Title:

A comprehensive cardiopulmonary simulation model for the analysis of hypercapnic respiratory failure

Author(s):

Chbat, Nicolas W.
Giannessi, Massimo
Albanese, Antonio
Ursino, Mauro

Date:

2009

Type:

Articles

Department:

Biomedical Engineering

Permanent URL:

http://hdl.handle.net/10022/AC:P:9418

Book/Journal Title:

EMBC 2009: Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: "Engineering the Future of Biomedicine": 2-6 September, 2009, Hilton Minneapolis, Minnesota

Publisher:

IEEE

Publisher Location:

Piscataway, N.J.

Abstract:

We developed a new comprehensive cardiopulmonary model that takes into account the mutual interactions between the cardiovascular and the respiratory systems along with their short-term regulatory mechanisms. The model includes the heart, systemic and pulmonary circulations, lung mechanics, gas exchange and transport equations, and cardio-ventilatory control. Results show good agreement with published patient data in case of normoxic and hyperoxic hypercapnia simulations. In particular, simulations predict a moderate increase in mean systemic arterial pressure and heart rate, with almost no change in cardiac output, paralleled by a relevant increase in minute ventilation, tidal volume and respiratory rate. The model can represent a valid tool for clinical practice and medical research, providing an alternative way to experience-based clinical decisions.

Subject(s):

Biomedical engineering

DOI:

http://dx.doi.org/10.1109/IEMBS.2009.5334567

Item views:

318

Metadata:

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