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A comprehensive cardiopulmonary simulation model for the analysis of hypercapnic respiratory failure

Nicolas W. Chbat; Massimo Giannessi; Antonio Albanese; Mauro Ursino

Title:
A comprehensive cardiopulmonary simulation model for the analysis of hypercapnic respiratory failure
Author(s):
Chbat, Nicolas W.
Giannessi, Massimo
Albanese, Antonio
Ursino, Mauro
Date:
Type:
Articles
Department:
Biomedical Engineering
Permanent URL:
Book/Journal Title:
EMBC 2009: Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: "Engineering the Future of Biomedicine": 2-6 September, 2009, Hilton Minneapolis, Minnesota
Publisher:
IEEE
Publisher Location:
Piscataway, N.J.
Abstract:
We developed a new comprehensive cardiopulmonary model that takes into account the mutual interactions between the cardiovascular and the respiratory systems along with their short-term regulatory mechanisms. The model includes the heart, systemic and pulmonary circulations, lung mechanics, gas exchange and transport equations, and cardio-ventilatory control. Results show good agreement with published patient data in case of normoxic and hyperoxic hypercapnia simulations. In particular, simulations predict a moderate increase in mean systemic arterial pressure and heart rate, with almost no change in cardiac output, paralleled by a relevant increase in minute ventilation, tidal volume and respiratory rate. The model can represent a valid tool for clinical practice and medical research, providing an alternative way to experience-based clinical decisions.
Subject(s):
Biomedical engineering
Publisher DOI:
http://dx.doi.org/10.1109/IEMBS.2009.5334567
Item views:
372
Metadata:
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