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Chlorophyll derivatives as visual pigments for super vision in the red

Ilyas Washington; Jilin Zhou; Steffen Jockusch; Nicholas J. Turro; Koji Nakanishi; Janet R. Sparrow

Title:
Chlorophyll derivatives as visual pigments for super vision in the red
Author(s):
Washington, Ilyas
Zhou, Jilin
Jockusch, Steffen
Turro, Nicholas J.
Nakanishi, Koji
Sparrow, Janet R.
Date:
Type:
Articles
Department:
Chemistry
Volume:
6
Permanent URL:
Book/Journal Title:
Photochemical & Photobiological Sciences
Abstract:
The primary event in vision is light-initiated activation of visual pigments. All visual pigments consist of the protein opsin bound to 11-cis-retinal and are responsible for initiating the transformation of light into an electrical signal. In a mouse model, we show that derivatives of chlorophyll can act as visual pigments initiating the transformation of light into an electrical signal and thus change the primary event in vision to initial activation of a chlorophyll derivative. Electroretinographic b-wave amplitudes recorded in response to red and blue light were two-fold greater in mice administered chlorin e6, which accumulated in photoreceptor outer segments.
Subject(s):
Chemistry
Publisher DOI:
http://dx.doi.org/10.1039/b618104j
Item views:
343
Metadata:
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