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A Microrobotic System For Protein Streak Seeding

Atanas Georgiev; Peter K. Allen; Ting Song; Andrew F. Laine; William Edstrom; John F. Hunt

Title:
A Microrobotic System For Protein Streak Seeding
Author(s):
Georgiev, Atanas
Allen, Peter K.
Song, Ting
Laine, Andrew F.
Edstrom, William
Hunt, John F.
Date:
Type:
Technical reports
Department:
Computer Science
Permanent URL:
Series:
Columbia University Computer Science Technical Reports
Part Number:
CUCS-041-04
Publisher:
Department of Computer Science, Columbia University
Publisher Location:
New York
Abstract:
We present a microrobotic system for protein crystal micromanipulation tasks. The focus in this report is on a task called streak seeding, which is used by crystallographers to entice certain protein crystals to grow. Our system features a set of custom designed micropositioner end-effectors we call microshovels to replace traditional tools used by crystallographers for this task. We have used micro-electrical mechanical system (MEMS) techniques to design and manufacture various shapes and quantities of microshovels. Visual feedback from a camera mounted on the microscope is used to control the micropositioner as it lowers a microshovel into the liquid containing the crystals for poking and streaking. We present experimental results that illustrate the applicability of our approach.
Subject(s):
Computer science
Item views:
109
Metadata:
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