Subject: Bioinformatics / Type: Theses | Search Results

1. Generating Reliable and Responsive Observational Evidence: Reducing Pre-analysis Bias

: Ostropolets, Anna
: 2023
: Theses
: BioinformaticsDecision makingPhenotype

2. Genetic and environmental determinants of recombination in coronaviruses

: Diuk-Wasser, Maria
: 2023
: Theses
: VirologyBioinformaticsEvolution (Biology)Coronaviruses--GeneticsCoronavirus infectionsMachine learning--Industrial applications

3. Genotype-Phenotype Correlation of T Cells from Aged and Alzheimer's Disease Subjects

: Dressman, Dallin
: 2023
: Theses
: ImmunologyBioinformaticsNeurosciencesAlzheimer's disease--Genetic aspectsPhenotypeMicrogliaNucleotide sequenceGene expression--Research--Methodology

4. Identifying and Targeting Master Regulators of Drug Resistance in Lung Adenocarcinoma through Network Analysis of Tumor Transcriptomic Data

: Griffin, Aaron Timothy
: 2023
: Theses
: BioinformaticsBiology--ClassificationStatisticsBiochemical markersLungs--CancerAdenocarcinomaDrug resistance in cancer cellsMachine learning--Industrial applicationsAmerican Society of Clinical OncologyMemorial Sloan-Kettering Cancer Center

5. Prediction of Human Gut Bacterial Secreted Proteins and their Interactions with Human Colonic Proteins

: Velez-Cortes, Florencia
: 2023
: Theses
: BioinformaticsIntestines--MicrobiologyDigestive organs--BacteriologyBacteriology

6. The itaconate-driven immunometabolic response to S. aureus promotes persistent lung infection

: Tomlinson, Kira Leigh
: 2023
: Theses
: MicrobiologyImmunologyBioinformaticsStaphylococcus aureus infectionsBiofilmsGlycolysisPneumoniaNeutrophils--Immunology

7. Using electronic health records to understand COVID-19 risks

: Ramlall, Vijendra
: 2023
: Theses
: BioinformaticsCOVID-19 (Disease)--EpidemiologyCOVID-19 (Disease)--Data processingCOVID-19 (Disease)--Risk factorsRetinal degenerationBlood coagulation disorders

8. Common and rare genetic effects on the transcriptome and their contribution to human traits

: Einson, Jonah
: 2022
: Theses
: BioinformaticsHuman genetics--VariationBiology--ClassificationHuman genomeGenetic regulation

9. Mind the developmental gap: Identifying adverse drug effects across childhood to evaluate biological mechanisms from growth and development

: Giangreco, Nicholas Paul
: 2022
: Theses
: BioinformaticsDevelopmental biologyChild developmentDrugs--Safety measuresDrugs--ToxicologyMedical statistics

10. Myeloid Heterogeneity in the Hippocampus

: Chintamen, Sana
: 2022
: Theses
: NeurosciencesImmunologyBioinformaticsHippocampus (Brain)Developmental neurobiologyMice as laboratory animalsMacrophages--ResearchMicroglia

11. Systems-Level Approaches to Understanding Protein Synthesis

: Metz, Jordan Benjamin
: 2022
: Theses
: BiologyComputer scienceBioinformaticsNucleotide sequenceRibosomesProteins--Synthesis--RegulationRNA-protein interactionsAnimal models in research

12. A Comparative Analysis of Genome Rearrangement in Ciliates

: Feng, Yi
: 2021
: Theses
: BiologyBioinformaticsEvolution (Biology)Gene rearrangementCiliata--GeneticsEuplotesGenetic code

13. Characterizing molecular drivers of clinical outcome in pediatric acute leukemias by systems biology and machine learning

: Alloy, Alexandre Paul
: 2021
: Theses
: BioinformaticsLeukemia--Genetic aspectsLeukemia in childrenMachine learningAcute leukemia

14. Genetic regulatory variant effects across tissues and individuals

: Flynn, Elise Duboscq
: 2021
: Theses
: BioinformaticsMedical geneticsGene expression--ResearchHuman genomeCoronary heart disease--Genetic aspectsCoronary arteriesPhenotype

15. Integration of Functional Genomic Data in Genetic Analysis

: Chen, Siying
: 2021
: Theses
: BioinformaticsMedical genetics--ResearchHuman genomeEpigeneticsAutism spectrum disorders--Genetic aspects

16. Mechanisms Underlying Phenotypic Heterogeneity in Simplex Autism Spectrum Disorders

: Chiang, Andrew Hann
: 2021
: Theses
: GeneticsBiologyBioinformaticsAutism spectrum disorders--Genetic aspectsPhenotypeMutagenesis

17. Metabolic evaluation of genetic and environmental contributors to Alzheimer’s disease

: Kalia, Vrinda
: 2021
: Theses
: Environmental healthBioinformaticsToxicologyAlzheimer's disease--Genetic aspectsCaenorhabditis elegansAfrican AmericansCaribbean AmericansWhite people

18. Methods for modeling the dynamics of microbial communities

: Joseph, Tyler
: 2021
: Theses
: BioinformaticsNucleotide sequenceMicrobiologyBiotic communitiesIrritable colon

19. Post-transcriptional gene expression regulation in developmental disorders

: Kitaygorodsky, Alexander
: 2021
: Theses
: BioinformaticsGeneticsComputer scienceGene expressionGenomesNeural networks (Neurobiology)

20. Towards unified medical evidence computation from literature for evidence-based medicine

: Kang, Tian
: 2021
: Theses
: BioinformaticsMedical care--Mathematical modelsMedicine

21. Computational Analysis of Biomolecular Data for Medical Applications from Bulk to Single-cell

: Zhu, Kaiyi
: 2020
: Theses
: Electrical engineeringBioinformaticsNucleotide sequenceDNARNABiomolecules--AnalysisMolecular diagnosis

22. Electronic Health Record-Derived Phenotyping Models to Improve Genomic Research in Stroke

: Thangaraj, Phyllis Mary
: 2020
: Theses
: BioinformaticsGeneticsCerebrovascular diseaseCerebrovascular disease--Risk factorsMedical records--Data processingMachine learning--Industrial applications

23. Generative Models for Synthetic Biology

: Blazejewski, Tomasz
: 2020
: Theses
: BioinformaticsBiology--ClassificationMolecular biologySynthetic biologyMachine learningAmino acid sequence

24. Loop Prediction and Homology Modeling with High Resolution

: Xu, Tianchuan
: 2020
: Theses
: BioinformaticsProteins--Structure--Computer simulationHomology (Biology)Sequence alignment (Bioinformatics)

25. Mosaicism and the genetic architecture of congenital heart disease

: Hsieh, Alexander Lin
: 2020
: Theses
: BioinformaticsGeneticsCongenital heart diseaseMosaicismDiseases--Causes and theories of causation

26. Spatial and genomic analysis of the glioblastoma tumor microenvironment

: Chen, Andrew
: 2020
: Theses
: BiologyBioinformaticsGlioblastoma multiformeMacrophages--Research

27. The autophagosomal perspective: Tissue-specificity and cell-specificity of the autophagic response to starvation in vivo

: Yang, Young Joo
: 2020
: Theses
: Molecular biologyBioinformaticsVeterinary medicineAutophagic vacuoles

28. Biological Insights from Geometry and Structure of Single-Cell Data

: Sharma, Roshan
: 2019
: Theses
: BioinformaticsMathematicsT cells--DifferentiationGeometrySingle cell proteins

29. Computational Toxinology

: Romano, Joseph Daniel
: 2019
: Theses
: BioinformaticsVenom--Therapeutic useMedical informaticsDrugs--Research

30. Investigating and Supporting Sensemaking within Online Health Communities

: Nakikj, Drashko
: 2019
: Theses
: Information scienceComputer scienceBioinformaticsMedical informaticsOnline social networksMedical sciences

31. Investigating the utility of exome sequencing for kidney disease

: Groopman, Emily
: 2019
: Theses
: GeneticsBioinformaticsMedicineKidneys--DiseasesExomes

32. New Tools for Understanding and Engineering Complex Microbial Communities

: Sheth, Ravi Uday
: 2019
: Theses
: BiologyBioinformaticsMicroorganismsMicrobial ecology--Technique

33. Simulating drug responses in laboratory test time series with deep generative modeling

: Yahi, Alexandre
: 2019
: Theses
: BioinformaticsPharmacologyDecision support systemsMachine learningNeural networks (Computer science)

34. Systems Genetics of DNA Damage Tolerance – Cisplatin, RAD5 & CRISPR-mediated Nonsense

: Bryant, Eric Edward
: 2019
: Theses
: GeneticsBioinformaticsBiology--ClassificationDNA damageCisplatinCRISPR (Genetics)

35. Adapting and Optimizing CBV-MRI and MEGAPRESS-MRS to Measure Slow Functional Changes in Normal and Abnormal Brains

: Guo, Jia
: 2018
: Theses
: Biomedical engineeringNeurosciencesBioinformaticsBrain--Localization of functionsBrain--ImagingNeurochemistry

36. Analysis of Oncogenic Signal Transduction with Application to KRAS Signaling Pathways

: Broyde, Joshua
: 2018
: Theses
: BioinformaticsBiometryMolecular biologyCancer--Molecular aspectsCellular signal transductionOncology

37. A Single-Cell Immune Map of Normal and Cancerous Breast Reveals an Expansion of Phenotypic States Driven by the Tumor Microenvironment

: Carr, Ambrose James
: 2018
: Theses
: BioinformaticsOncologyComputer scienceImmunologyTumors

38. Attractor Metafeatures and Their Application in Biomolecular Data Analysis

: Ou Yang, Tai-Hsien
: 2018
: Theses
: BioinformaticsElectrical engineeringAttractors (Mathematics)AlgorithmsBiochemical markers

39. Characterizing Immune Responses to Marburg Virus Infection in Animal Hosts Using Statistical Transcriptomic Analysis

: Lee, Albert Kim
: 2018
: Theses
: BioinformaticsMarburg virusHost-virus relationshipsVirus diseases--Immunological aspectsImmunology

40. Genomic and machine-learning analysis of germline variants in cancer

: Madubata, Chioma
: 2018
: Theses
: BioinformaticsCytologyGeneticsMachine learningGerm cellsCancer

41. Leveraging patient-provided data to improve understanding of disease risk

: da Graca Polubriaginof, Fernanda Caroline
: 2018
: Theses
: MedicineBioinformaticsMedical sciencesDiseases--Risk factors

42. Optimizing the Collection and Use of Patient-Generated Health Data

: Reading, Meghan J.
: 2018
: Theses
: NursingBioinformaticsMedical recordsHealth services administrationPublic health

43. Quantitative Approaches to the Genomics of Clonal Evolution

: Zairis, Sakellarios
: 2018
: Theses
: GeneticsBioinformaticsMathematicsGenomicsClones (Plants)Evolution (Biology)

44. Regulation of splicing networks in neurodevelopment

: Weyn-Vanhentenryck, Sabastien Matthieu
: 2018
: Theses
: BioinformaticsNeurosciencesRNA splicingRNA-protein interactions

45. Regulatory logic of cellular diversity in the nervous system

: Closser, Michael Edward
: 2018
: Theses
: Molecular biologyNeurosciencesBioinformaticsNervous systemGene expressionCellular control mechanisms

46. Systematically Mapping the Epigenetic Context Dependence of Transcription Factor Binding

: Kribelbauer, Judith Franziska
: 2018
: Theses
: BiochemistryBioinformaticsBiophysicsTranscription factorsGene regulatory networksEpigenetics

47. The generation and phenotypic effect of human genetic mutations

: Chen, Chen
: 2018
: Theses
: BioinformaticsComputer scienceMutation (Biology)Human genetics--VariationMachine learning

48. Assessing the potential of a diabetes self-management technology intervention for underserved adults

: Heitkemper, Elizabeth Mary
: 2017
: Theses
: NursingBioinformaticsMedical technologyPatient self-monitoringMedically underserved areasDiabetes--Treatment

49. A Systems-Level Approach to Understand The Seasonal Factors Of Early Development With Clinical and Pharmacological Applications

: Boland, Mary Regina
: 2017
: Theses
: BioinformaticsMedical sciencesDiseases--Seasonal variationsAbnormalities, HumanDiseases--Causes and theories of causation

50. Developing Statistical Methods for Incorporating Complexity in Association Studies

: Palmer, Cameron Douglas
: 2017
: Theses
: BioinformaticsHuman genome--ResearchStatisticsGenomics--Statistical methodsResearch--Data processing

51. Discovering new drug-drug interactions using data science: Applications to drug-induced Long QT Syndrome

: Lorberbaum, Tal
: 2017
: Theses
: BioinformaticsPhysiologyPharmacologyDrug interactionsLong QT syndrome

52. Empirical Bayes, Bayes factors and deoxyribonucleic acid fingerprinting

: Basu, Ruma
: 2017
: Theses
: StatisticsDNA fingerprintingBioinformatics

53. Leveraging Knowledge-Based Approaches to Promote Antiretroviral Toxicity Monitoring in Underserved Settings

: Ogallo, William
: 2017
: Theses
: Medical sciencesInformation scienceAntiretroviral agentsToxicity testingBioinformatics

54. Molecular Dynamics Simulations of Microtubule-associated protein 1A/1B-light chain 3 (LC3) and its membrane associated form(LC3-II)

: Mathew, Shyno
: 2017
: Theses
: Chemical engineeringMolecular biologyBioinformaticsAutophagic vacuoleMolecular dynamics

55. Structure Function Analysis of Drug Resistance Driver Mutations in Acute Lymphoblastic Leukemia

: Carpenter, Zachary Wayne
: 2017
: Theses
: Lymphoblastic leukemia in childrenPediatric hematologyBones--Cancer--TreatmentBone marrow--CancerDrug resistance in cancer cellsLymphoblastic leukemiaBioinformaticsOncologyPharmacology

56. Systems biology approaches to precision medicine

: He, Jing
: 2017
: Theses
: BioinformaticsCytologyComputer scienceSystems biologyMedicine

57. Using interspecies biological networks to guide drug therapy

: Jacunski, Alexandra
: 2017
: Theses
: BioinformaticsCombination drug therapyDrug interactions

58. Assessment and Documentation of Sexual Orientation and Gender Identity in Home Healthcare

: Bjarnadottir, Ragnhildur I.
: 2016
: Theses
: Sexual orientationGender identityNurse and patientBioinformaticsHealth services administrationNursingPublic healthMedical care

59. Computational Approaches to Characterizing Online Health Communities

: Zhang, Shaodian
: 2016
: Theses
: BioinformaticsPatients--AttitudesChronically ill--AttitudesOnline social networks

60. Confounding effects in gene expression and their impact on downstream analysis

: Lachmann, Alexander
: 2016
: Theses
: Genetic regulationGenetic regulation--Data processingGene expressionGene expression--Data processingBioinformaticsGene regulatory networksGenetics

61. Genetics of ABCA4-associated Diseases and Retinitis Pigmentosa

: Xie, Yajing
: 2016
: Theses
: Retinitis pigmentosaRetinitis pigmentosa--Genetic aspectsMedical geneticsRetinal degenerationGeneticsBioinformatics

62. Learning cell states from high-dimensional single-cell data

: Levine, Jacob Harrison
: 2016
: Theses
: BioinformaticsCells--MeasurementMyeloid leukemiaCells--Computer programsBiologyOncology

63. Ontology-based Semantic Harmonization of HIV-associated Common Data Elements for Integration of Diverse HIV Research Datasets

: Brown III, William
: 2016
: Theses
: BioinformaticsHIV (Viruses)--ResearchHIV infections--ResearchHIV infectionsInformation scienceInformation technologyMedical sciences

64. Patient Engagement to Improve Medication Safety in the Hospital

: Prey, Jennifer Elizabeth
: 2016
: Theses
: BioinformaticsPatient safetyMedicine--Safety measuresPatients--Safety measures

65. Systems Biology Approaches to The Study of Neurological Disorders and Somatic Cell Reprogramming

: Shin, William Kihoon
: 2016
: Theses
: Cell hybridizationCentral nervous system--DiseasesNervous system--DegenerationGenetic transcriptionBioinformaticsNeurosciencesBiology--Classification

66. Topics in Signal Processing: applications in genomics and genetics

: Elmas, Abdulkadir
: 2016
: Theses
: Signal processingSignal processing--Statistical methodsGenetics--Data processingGenomics--Data processingBioinformaticsTranscription factorsElectrical engineering

67. Toward a Generalized Model of Biomedical Query Mediation to Improve Electronic Health Record Data Retrieval

: Hruby, Gregory William
: 2016
: Theses
: Medical recordsBioinformaticsMedical electronicsMedical records--Data processingInformation science

68. Use of informatics methods to identify problems and then design, develop and evaluate solutions to support health workers in their management of malaria...

: Carlo Unda, Maria Lorena
: 2016
: Theses
: Malaria--TreatmentBioinformaticsMillennium Villages (Project)User-centered system designHealth services administrationMalaria--PreventionInformation technologyComputer scienceMedical care

69. Cell Memory in the Mitogen-Activated Protein Kinase Signaling Pathway

: Lyashenko, Eugenia
: 2015
: Theses
: Mitogen-activated protein kinasesWeber-Fechner lawCellular control mechanismsBioinformaticsBiology

70. Combining Heterogeneous Databases to Detect Adverse Drug Reactions

: Li, Ying
: 2015
: Theses
: Bioinformatics

71. Computational integration of genome-wide observational and functional data in cancer

: Sanchez Garcia, Felix
: 2015
: Theses
: Computer scienceBioinformaticsBiology

72. Electronic Health Record Summarization over Heterogeneous and Irregularly Sampled Clinical Data

: Pivovarov, Rimma
: 2015
: Theses
: BioinformaticsPatient monitoring--Data processingMedical records--Data processingMedical sciencesHealth services administrationMedical care

73. Enabling the Reuse of Electronic Health Record Data through Data Quality Assessment and Transparency

: Weiskopf, Nicole Gray
: 2015
: Theses
: Medicine--Information technologyMedical records--EvaluationInformation technology--EvaluationMedical records--Data processingBioinformaticsMedicine

74. Global Survey of Cell Death Mechanisms Reveals Metabolic Regulation of GPX4-Dependent Ferroptosis

: Shimada, Kencihi
: 2015
: Theses
: HomeostasisMetabolismBioinformaticsPharmacologyCell deathMolecular biology

75. Identifying and reducing inappropriate use of medications using Electronic Health Records

: Salmasian, Hojjat
: 2015
: Theses
: Drug utilization--EvaluationMedical records--Data processingMedical sciencesBioinformaticsMedicine

76. Identifying genes required for the formation of neurons from skin cells using forward genetic screens and whole genome sequencing in C. elegans

: Minevich, Gregory
: 2015
: Theses
: Neurons--GrowthNeural stem cellsDevelopmental neurobiologyGene mappingGeneticsNeurosciencesBioinformatics

77. Interrogating Drug Mechanism of Action Using Network Dysregulation Analysis

: Woo, Junghoon
: 2015
: Theses
: Technological innovationsMedical protocolsDrugs--Mechanism of actionBioinformaticsDrugs

78. Mining patterns in genomic and clinical cancer data to characterize novel driver genes

: Melamed, Rachel D.
: 2015
: Theses
: BioinformaticsOncologyBiology--Classification

79. On Identifying Rare Variants for Complex Human Traits

: Fan, Ruixue
: 2015
: Theses
: Regression analysisGenetics--Statistical methodsGenomics--Data processingHuman genetics--VariationStatisticsBioinformatics

80. Transcriptional States and microRNA Regulation of Adult Neural Stem Cells

: DeLeo, Annina
: 2015
: Theses
: Molecular biologyNeurosciencesBioinformatics

81. Understanding and Reducing Clinical Data Biases

: Fort, Daniel
: 2015
: Theses
: Bioinformatics

82. Aberrantly Expressed CeRNAs Account for Missing Genomic Variability of Cancer Genes via MicroRNA-Mediated Interactions

: Chiu, Hua-Sheng
: 2014
: Theses
: CarcinogenesisOncogenesBioinformaticsRNABiology--ClassificationGenetics

83. Analysis of trans eSNPs infers regulatory network architecture

: Kreimer, Anat
: 2014
: Theses
: Bioinformatics

84. Heterogeneity and Context-Specificity in Biological Systems

: Litvin, Oren
: 2014
: Theses
: BiologyBioinformaticsGenetics—ResearchBacterial diversity--Genetic aspectsGenetics--Mathematical models

85. Identification of microRNA Biogenesis Regulators and Activity Modulators

: Chung, Wei-Jen
: 2014
: Theses
: Cancer--Genetic aspectsMetastasisGenetic regulationRNABioinformaticsMolecular biology

86. Large-scale Functional Connectivity in the Human Brain Reveals Fundamental Mechanisms of Cognitive, Sensory and Emotion Processing in Health and Psychiatric Disorders

: Pantazatos, Spiro
: 2014
: Theses
: NeurosciencesPsychobiologyBioinformaticsHippocampus (Brain)PerceptionCognitionAutismPrefrontal cortexCerebellum

87. Learning from cadherin structures and sequences: affinity determinants and protein architecture

: Felsovalyi, Klara
: 2014
: Theses
: Protein bindingCadherinsBiochemistryBioinformaticsBiophysics

88. Structure-Based Genome Scale Function Prediction and Reconstruction of the Mycobacterium tuberculosis Metabolic Network

: Konate, Mariam
: 2014
: Theses
: Bioinformatics

89. viSNE and Wanderlust, two algorithms for the visualization and analysis of high-dimensional single-cell data

: Amir, El-ad David
: 2014
: Theses
: ImmunologyBioinformatics

90. Analyzing Genomic Studies and a Screen for Genes that Suppress Information Loss During DNA Damage Repair

: Pierce, Steven
: 2013
: Theses
: BiologyCytologyBioinformatics

91. A Novel Platform to Perform Cancer-Relevant Synthetic Dosage Lethality Screens in Saccharomyces cerevisiae

: Dittmar, John
: 2013
: Theses
: BioinformaticsBiologyGenetics

92. Attractor Molecular Signatures and Their Applications for Prognostic Biomarkers

: Cheng, Wei-Yi
: 2013
: Theses
: Electrical engineeringBioinformatics

93. Computational Contributions Towards Scalable and Efficient Genome-wide Association Methodology

: Prabhu, Snehit
: 2013
: Theses
: BioinformaticsComputer science

94. Computational Inferences of Mutations Driving Mesenchymal Differentiation in Glioblastoma

: Chen, James C.
: 2013
: Theses
: Mutation (Biology)Mesenchymal stem cells--DifferentiationSystems biologyRetinoblastomaBioinformaticsGeneticsBiology

95. Dissecting genetic determinants of transcription factor activity

: Lee, Eunjee
: 2013
: Theses
: BiologyBioinformatics

96. Exploring the Plasmodium falciparum Transcriptome Using Hypergeometric Analysis of Time Series (HATS)

: Scanfeld, Daniel
: 2013
: Theses
: BioinformaticsParasitologyPlasmodium falciparumMalariaDrug resistance

97. Network based analysis of genetic disease associations

: Gilman, Sarah Roche
: 2013
: Theses
: Bioinformatics

98. Probabilistic Reconstruction and Comparative Systems Biology of Microbial Metabolism

: Plata Caviedes, German
: 2013
: Theses
: MicrobiologyBioinformaticsEvolution (Biology)BacteriologyPhenotypeGene expression

99. An Integrative Review of the Literature on Technology Transformation in Healthcare

: Phillips, Andrew Bartlett
: 2012
: Theses
: BioinformaticsMedical technologyMedical care--Technological innovationsPatient Protection and Affordable Care Act (United States)

100. Genome-wide Predictive Simulation on the Effect of Perturbation and the Cause of Phenotypic variations with Network Biology Approach

: Jang, In Sock
: 2012
: Theses
: Electrical engineeringBioinformatics

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