1. Application and development of methods towards the target identification of biologically-active small molecules SriRamaratnam, Rohitha 2011 Theses ChemistryBiologyMoleculesBiochemistryBiochemical geneticsGene targeting
2. Characterizing the Interaction of the ATP Binding Cassette Transporters (G subfamily) with the Intracellular Protein Lipid Environment Gulati, Sonia 2011 Theses BiochemistryMedical sciences
3. Ferroptosis: A Novel Form of Cancer Cell Death Induced by the Small Molecule Erastin Lemberg, Kathryn 2011 Theses BiologyBiochemistryChemistryApoptosisCell deathCancer
4. Gates and Latches: the mechanochemistry of ATP binding in kinesin 1 and Eg5 Behnke-Parks, William M. 2011 Theses BiologyBiophysicsBiochemistryKinesinMechanical chemistryCell division
5. Ligand-Protein Interactions in Cytochromes Catalano, Jaclyn 2011 Theses ChemistryBiochemistryBiophysics
6. Molecular Mechanisms Controlling Synaptic Vesicle Fusion Radoff, Daniel Todd 2011 Theses BiochemistrySynaptic vesiclesCell membranesMembrane proteins
7. Regulation of alternative splicing and its connections to cancer Chen, Mo 2011 Theses BiologyMolecular biologyBiochemistryRNA splicingPyruvate kinaseCancer cellsExons (Genetics)Mammals--Genetics
8. Studies on mammalian pre-mRNA splicing : connections to transcription and cancer David, Charles J. 2011 Theses BiochemistryMolecular biologyRNA splicingCancer--Genetic aspectsCancer cellsMammals--GeneticsGlycolysis
9. The Ribosome Discriminates the Structure of the Amino Acid at its Peptidyl-Transferase Center Englander, Michael Thomas 2011 Theses BiochemistryRibosomesAmino acidsCrick, Francis, 1916-2004
10. The Role of Initiation Factor Dynamics in Translation Initiation Elvekrog, Margaret Mary 2011 Theses ChemistryBiophysicsBiochemistry
11. Towards High-resolution Computational Approaches for Structure-based Drug Discovery Li, Jianing 2011 Theses ChemistryChemistry, Physical and theoreticalBiochemistry
12. Ubiquitin Conformational Dynamics and Hydration Shell Dynamics by Solid State NMR Huang, Kuo-Ying 2011 Theses ChemistryBiochemistryNuclear magnetic resonanceCatalysisEnzymesDeuteriumUbiquitin
13. Visualizing the One-Dimensional Diffusion of DNA Mismatch Repair Proteins at the Single-Molecule Level Gorman, Jason 2011 Theses BiologyBiochemistryBiophysicsDNA repairEukaryotic cells--Genetics
14. An Analysis of the Essential Chromatin Factor Zinc Finger Protein 1 (ZFP-1), and a Study of the Involvement of RNAi factors in Histone Processing in Caenorabditis Elegans Anastasiades Avgousti, Daphne Christina 2012 Theses BiochemistryBiophysicsCaenorhabditis elegansChromatinHistonesRNANucleosomes
15. Mechanism of Transcription Arrest By The Nun Protein of Bacteriophage HK022 Vitiello, Christal Lourdes 2012 Theses MicrobiologyBiochemistryBiology
16. Mechanochemical Methods for Single Molecule Biochemistry and Studies of Thiol-Disulfide Exchange in Proteins Kosuri, Pallav 2012 Theses BiophysicsBiochemistryBiology
17. MEMS-based temperature-dependent characterization of biomolecular interactions Wang, Bin 2012 Theses Mechanical engineeringBiochemistry
18. P-REX2 PH Domain Inhibition of PTEN Regulates Transformation, Insulin Signaling, and Glucose Homeostasis Hodakoski, Cindy Marie 2012 Theses BiologyBiochemistry
19. Single-Molecule Analysis of Ribosome and Initiation Factor Dynamics during the Late Stages of Translation Initiation MacDougall, Daniel David 2012 Theses Genetic translationBiochemistryRibosomesBiophysics
20. The Catalytic Efficiency and Conformational Dynamics of Escherichia coli DNA Repair Enzyme AlkB Ergel, Burce 2012 Theses BiochemistryBiophysicsOxidoreductasesCatalysisProteins
21. Building a Genetic System in Yeast to Search for High Affinity Proteins in Sequence Space Merguerian, Matthew Douglas 2013 Theses Molecular biologyBiochemistryCytologyProtein bindingYeast--GeneticsProtein engineering
22. CysZ: Structural and Functional Studies of a Novel Sulfate Transport Protein Assur, Zahra 2013 Theses CytologyCarrier proteinsBiochemistryBiophysics
23. I: Catalytic Direct C-H Arylation of Pyrazoles. II: Toward Modulation of Neuroplasticity with Small Molecules Jacques, Teresa 2013 Theses ChemistryChemistry, OrganicBiochemistryPyrazolesArylationNeuroplasticity
24. Novel Regulatory Mechanisms of Cytoplasmic Dynein: A Role for the Complex Base Weil, Sarah J. 2013 Theses BiologyBiochemistry
25. PTEN-LONG, a translational variant of the canonical tumor suppressor PTEN Hopkins, Benjamin 2013 Theses BiologyBiochemistryTumor suppressor proteinsAdenocarcinomaPancreas--Cancer--Research
26. Structural and Biochemical Characterizations of the Symplekin-Ssu72-CTD Complex in Pre-mRNA 3' end Processing Xiang, Kehui 2013 Theses BiochemistryGenetic transcriptionRNA polymerasesBiologyMolecular biology
27. Structural and Functional Studies of Biotin-Dependent Carboxylases Huang, Christine S. 2013 Theses BiochemistryBiophysics
28. Structure-based Design of Small Molecule Inhibitors of HIV-1 Entry Le-Khac, Matthew 2013 Theses BiochemistryPharmacology
29. Thermal adaptation of conformational dynamics in ribonuclease H Stafford, Kate 2013 Theses Biochemistry
30. Trimethoprim-Based Chemical Tags for High Resolution Live Cell Imaging Jing, Chaoran 2013 Theses ChemistryBiochemistryCytology
31. Engineering a Repeats-in-Toxin Scaffold for Stimulus-Responsive Biotechnology Applications Dooley, Kevin P. 2014 Theses Proteins--StructureChemical engineeringBiochemistryBiomedical engineering
32. Learning from cadherin structures and sequences: affinity determinants and protein architecture Felsovalyi, Klara 2014 Theses Protein bindingCadherinsBiochemistryBioinformaticsBiophysics
33. Molecular Basis for the Recognition of the Regulatory Stem-loop Structures in Eukaryotic Messenger RNAs Tan, Dazhi 2014 Theses Messenger RNARNA-protein interactionsEukaryotic cellsBiologyBiochemistryMolecular biology
34. Structural and biophysical characterization of protocadherin extracellular regions Wolcott, Holly Noelle 2014 Theses BiochemistryBiophysics
35. The role of phosphatidylinositol 3-kinases in autophagy regulation Devereaux, Kelly Anne 2014 Theses Autophagic vacuoleBiochemistryPhosphoinositidesCytologyPathology
36. Understanding two inhibitors of NF-κB: A20 and IκBβ De, Arnab 2014 Theses Glycogen synthase kinase-3NF-kappa B (DNA-binding protein)ImmunologyBiochemistryChemistry
37. Combined Biosynthetic and Synthetic Production of Valuable Molecules: A Hybrid Approach to Vitamin E and Novel Ambroxan Derivatives Adanve, Bertrand Tankpinou 2015 Theses Organic compounds--SynthesisVitamin ESynthetic biologyChemistryBiochemistry
38. Development of Trimethoprim Chemical Tags for Single Molecule Imaging in Live Cells Wang, Tracy Yuh 2015 Theses ChemistryBiochemistry
39. Electrodeposition and Electroless Deposition of Copper in Interconnect Technology and Biotechnology Related Applications Sun, Xiaoxuan 2015 Theses Chemical engineeringChemistryBiochemistry
40. Exploring an Interface Between Synthetic Chemistry and Chemical Biology: The Synthesis of Complex Natural Products and Novel Chemical Probes Thomas, Stephen Basil 2015 Theses Natural products--SynthesisBiochemistryChemistry, OrganicOrganic compounds--SynthesisChemistry
41. Harnessing Growth Selections in Saccharomyces cerevisiae for Biological Engineering Harton, Marie Deborah Gaynelle 2015 Theses Natural selectionSaccharomyces cerevisiae--GeneticsBiomedical engineeringBiochemistry
42. Identification and Biophysical Characterization of Small Molecules Modulating Protein Disulfide Isomerase in Neurodegenerative Diseases Kaplan, Anna 2015 Theses Nervous system--DegenerationNeuroprotective agentsProtein disulfide isomeraseBiophysicsBiochemistryBiology
43. Investigating the role of the RNA binding protein TDP-43 in Amyotrophic Lateral Sclerosis using animal and cell-based models of disease Lehrer, Helaina 2015 Theses Molecular biologyNeurosciencesBiochemistry
44. Protein Structure Dynamics and Function at Micelle and Particle Interfaces Chin, Michael 2015 Theses ChemistryBiochemistryBiophysics
45. Regulation Of Retroviral Silencing In Different Cell Types Wang, Cheng 2015 Theses RetrovirusesCellsMouse leukemia virusesBiochemistryVirology
46. Reprogramming protein synthesis for cell engineering Anzalone, Andrew Vito 2015 Theses Proteins--SynthesisBioengineeringAmino acids--BiotechnologyRNA-protein interactionsSynthetic biologyBiochemistryChemistry, OrganicBiologyMolecular biology
47. Structural Studies of the Fungal pre-mRNA 3'-end Processing Machinery Jurado, Ashley Rae 2015 Theses ProteinsRNA splicingScission (Chemistry)Messenger RNAMolecular biologyBiologyBiochemistry
48. The Regulation of PREX2 by Phosphorylation Barrows, Douglas Walker 2015 Theses PhosphorylationInsulin--Mechanism of actionPhosphoinositidesBiologyBiochemistryPharmacology
49. Winning the cellular lottery: how proteins reach and recognize targets in DNA Redding, Sy Eugene 2015 Theses Promoters (Genetics)DNA-protein interactionsDNA-binding proteinsBiophysicsBiochemistryBiology
50. Chloride Intracellular Channels 1 and 4 function in distinct branches of S1P signaling to regulate endothelial cell behavior and vascular development Jilishitz, Irina 2016 Theses MorphogenesisGrowth factorsNeovascularizationEndothelial cellsMolecular biologyBiochemistry
51. Cryo-electron microscopy studies of dynamical features of ribosomes during the translation process Sun, Ming 2016 Theses BiophysicsProteins--StructureRibosomes--StructureRibosomesCryoelectronicsBiologyBiochemistry
52. Examining the Effects of D-Amino Acids on Translation Fleisher, Rachel Chaya 2016 Theses Messenger RNAAmino acidsAmino acid sequenceRibosomesBiochemistryChemistry
53. Novel Methods for the Ribosomal Incorporation of β-Amino Acids Sanguineti, Gabriella 2016 Theses Amino acidsBiochemistry--MethodologyPeptides--SynthesisBiochemistry
54. Oxidative Folding in Bacteria: Studies Using Single Molecule Force Spectroscopy Kahn, Thomas 2016 Theses Protein foldingOxidoreductasesEscherichia coli--PhysiologyOxidationBiophysicsBiochemistry
55. Role of motor neuron autophagy in a mouse model of Amyotrophic Lateral Sclerosis Rudnick, Noam Daniel 2016 Theses Motor neuronsAutophagic vacuolesAmyotrophic lateral sclerosisNeurosciencesBiochemistryMedicine
56. Structural Studies of a Mammalian Epithelial Calcium Channel Saotome, Kei 2016 Theses Calcium--Physiological effectBiochemistryTRP channelsCalcium channels
57. Understanding complex biomolecular systems through the synergy of molecular dynamics simulations, NMR spectroscopy and X-Ray crystallography Zeiske, Tim 2016 Theses Molecular dynamics--Simulation methodsMolecular dynamics--Computer simulationNuclear magnetic resonance spectroscopyBiomolecules--Computer simulationX-ray crystallographyMacromolecules--StructureMolecular dynamicsBiophysicsBiochemistry
58. Artificial Metabolons: Design of Self-Assembled Bio-Complexes Garcia, Kristen E. 2017 Theses Chemical engineeringProteinsBiochemistry
59. Biochemical and Genetic Investigation of Immature Murine Leukemia Virus Assembly Tinaztepe, Sedef 2017 Theses VirologyBiochemistryCytologyMouse leukemia virusesCytoskeletal proteinsRetroviruses
60. Biology of maintenance and de novo methylation mediated by DNA methyltransferase-1 Yarychkivska, Olga 2017 Theses DNA--MethylationMethyltransferasesDNA replicationCell divisionGenomicsGeneticsBiochemistryBiology
61. Cryo-electron microscopy and single particle reconstructions of the Leishmania major ribosome and of the encephalomyocarditis virus internal ribosome entry site bound to the 40S subunit Jobe, Amy Beth 2017 Theses Electron microscopyRibosomesLeishmaniaRNACryoelectronicsBiologyBiochemistryBiophysics
62. Engineering Electron Transfer Processes in Oxidoreductases: Applications in Biocatalysis Ozbakir, Harun Ferit 2017 Theses Chemical engineeringBiochemistryOxidoreductasesBiocatalysis
63. Membrane partitioning by Flotillin-1 facilitates amphetamine-induced dopamine transporter activity Fong, Wendy Mei 2017 Theses BiochemistryNeurosciencesCytologyCell membranesCarrier proteins
64. Nanoscale Electrical and Coarse-grained Molecular Dynamics Studies of Influenza Hemagglutinin-mediated Membrane Fusion Pores Alcott, Brett Eugene 2017 Theses BiophysicsBiochemistryVirologyMolecular dynamicsMembrane fusion
65. PTEN affects gene expression and histone modifications and plays a role in the regulation of transcription Steinbach, Nicole 2017 Theses CytologyBiochemistryOncologyGene expressionGenetic transcription
66. Regulation of Release Factor 2 in Non-canonical Translation Pathways Huang, Bridget Yih Jiin 2017 Theses Bacterial proteinsRibosomesBiochemistryProteins--SynthesisBiophysics
67. RPGRIP1L and FTO – genes implicated in the effects of FTO intronic sequence variants on food intake – also affect adipogenesis and adipocyte biology. Martin-Carli, Jayne Frances 2017 Theses BiochemistryCytologyMolecular biologyObesity--Genetic aspects
68. Single-molecule observations of hRPA, RAD51, and RAD52 on single-stranded DNA Ma, Chu Jian 2017 Theses BiochemistryBiophysicsDNA replicationGenetic recombinationMolecular biology
69. Structural and Functional Studies of TRPML1 and TRPP2 Benvin, Nicole Marie 2017 Theses BiologyBiochemistryBiophysicsTRP channelsProteins--Structure
70. Structural and functional studies on the regulation of pyruvate carboxylase by the bacterial second messenger cyclic-di-AMP Choi, Philip H. 2017 Theses Enzymes--StructureListeria monocytogenesEnzymesPyruvate carboxylaseBiochemistryMicrobiology
71. Allosteric Coupling, Nucleotide Binding and ATP Hydrolysis by Hsp70 Chaperones on a Structural Basis Wang, Wei 2018 Theses BiologyBiochemistryBiophysicsAllosteric regulationHeat shock proteins
72. Characterization of a novel Ser/Thr kinase/phosphatase pair in Escherichia coli Rajagopalan, Krithika 2018 Theses MicrobiologyBiochemistryPhosphatasesProtein kinasesEscherichia coliSerine
73. Design and Synthesis of 3'-Oxygen-Modified Cleavable Nucleotide Reversible Terminators for Scarless DNA Sequencing by Synthesis Hsieh, Min-Kang 2018 Theses Chemical engineeringBiochemistryBiomedical engineeringNucleotide sequence
74. Development of Single Molecule Electronic SNP Assays using Polymer Tagged Nucleotides and Nanopore Detection Cho, Youngjin 2018 Theses BiochemistryBiomedical engineeringNanoporesSingle nucleotide polymorphisms
75. Dynamic Nuclear Polarization with Biradical Affinity Reagents Rogawski, Rivkah 2018 Theses BiophysicsChemistryBiochemistryPolarization (Nuclear physics)Biradicals
76. Integration of EGFR and LIN-12/Notch signaling in Vulval Precursor Cell fate specification in Caenorhabditis elegans Underwood, Ryan 2018 Theses BiochemistryMetazoaCell interactionCellular signal transductionBiophysics
77. Pathways for kidney triglyceride accumulation Scerbo, Diego 2018 Theses BiologyBiochemistryNutritionTriglyceridesKidneys--Diseases
78. Resonance-energy-transfer-based fluorescence imaging and free energy perturbation calculation Xu, Fang 2018 Theses Chemistry, Physical and theoreticalProtein-protein interactionsFluorescenceEnergy transferBiochemistry
79. Shared Molecular Features of Inherited and Sporadic ALS/FTD Conlon, Erin Grace 2018 Theses BiochemistryGeneticsNeurosciencesAmyotrophic lateral sclerosisFrontotemporal dementiaMolecular biology
80. Structural and biophysical studies of the Drosophila melanogaster Dpr and DIP families Cosmanescu, Filip 2018 Theses BiochemistryNeurosciencesBiophysicsDrosophila melanogasterNeurons
81. Structural and Functional Investigation of Bacterial Membrane Biosynthesis Belcher Dufrisne, Meagan Leigh 2018 Theses BiochemistryBacterial cell walls--SynthesisPhosphoinositidesBiosynthesisEnzymesTuberculosis--TreatmentPeptidoglycansMycoplasmataceae
82. Structural Studies of the Integrator Complex -- pre-UsnRNA 3'-end Processing Machinery Wu, Yixuan 2018 Theses BiologyBiochemistryCatalytic RNA
83. Systematically Mapping the Epigenetic Context Dependence of Transcription Factor Binding Kribelbauer, Judith Franziska 2018 Theses BiochemistryBioinformaticsBiophysicsTranscription factorsGene regulatory networksEpigenetics
84. Targeting neurons with small molecule probes: from imaging to modulation Boltaev, Umed Tolibovich 2018 Theses ChemistryBiochemistryNeurosciencesNeuronsMolecular probes
85. The BARD1 BRCT Domain in Tumor Suppression and Genome Stability Billing, David 2018 Theses Molecular biologyCytologyBiochemistryTumor suppressor proteinsGenomes
86. The Role of Eukaryotic Recombinase Loop L1 During Homologous Recombination Steinfeld, Justin Benjamin 2018 Theses BiophysicsBiochemistryGeneticsGenetic recombinationEukaryotic cells
87. The Role of Modified UNC-68 in Age-related Caenorhabditis elegans Muscle Function Loss Forrester, Frances M. 2018 Theses PhysiologyBiochemistryCaenorhabditis elegansMuscle cells
88. The Saccharomyces cerevisiae Srs2 Helicase Regulates Homologous Recombination through the Disassembly of Recombination Intermediates Kaniecki, Kyle Stephen 2018 Theses GeneticsBiophysicsBiochemistrySaccharomyces cerevisiaeGenetic recombination
89. Biomolecular NMR spectroscopy: Application to the study of the piRNA-pathway protein GTSF1, and backbone and side-chain spin relaxation methods development O'Brien, Paul 2019 Theses BiophysicsBiochemistryNuclear magnetic resonance spectroscopyProteins--StructureMolecular dynamics
90. Genetic Mechanisms of Regulated Stochastic Gene Expression Horta, Adan 2019 Theses NeurosciencesBiochemistryGeneticsOlfactory receptor genesGene expressionCadherinsHuman genetics--Variation
91. Liver X Receptor cis-Repression and Cholesterol Efflux Restrain Innate Immunity and Coronary Artery Disease Thomas, David George 2019 Theses CytologyMolecular biologyBiochemistryAtherosclerosis--PreventionImmunityNuclear receptors (Biochemistry)
92. Mechanisms and therapeutic targeting of NT5C2 mutations in relapsed acute lymphoblastic leukemia Dieck, Chelsea 2019 Theses BiochemistryLymphoblastic leukemiaDrug resistanceOncologyMutation (Biology)Molecular biology
93. Molecular Approaches to Targeting Oncogenic KRAS and Ferroptosis Feng, Huizhong 2019 Theses Molecular biologyBiochemistryCytologyBiochemical markersCancerCell death
94. Novel functions of C9ORF72, a gene involved in ALS/FTD Fomin, Vitalay 2019 Theses BiologyBiochemistryGeneticsCytologyAmyotrophic lateral sclerosisFrontotemporal dementiaGene expression
95. Nucleosome Curtains and their application to the study of DNA condensation by condensin Moevus, Corentin Jean 2019 Theses BiochemistryBiophysicsDNACondensed matter
96. Solving Challenging Structures using Single-Particle Cryogenic Electron Microscopy Tan, Yong Zi 2019 Theses BiochemistryBiophysicsElectron microscopyMacromolecules--StructureRibosomesMembrane proteinsCytology--Technique
97. Structural Analyses of the Transient Receptor Potential Channels TRPV3 and TRPV6 McGoldrick, Luke Lawrence Reedy 2019 Theses BiochemistryMolecular biologyTRP channelsStructure-activity relationships (Biochemistry)Ion channels
98. Structural Investigation of Plasmodium falciparum Chloroquine Resistance Transporter in the Context of Anti-Malarial Drug Resistance Kim, Jonathan Young 2019 Theses BiochemistryMalariaDrug resistanceAntimalarialsDrugs--Physiological transport
99. Structural studies of the yeast transcription termination complex Nrd1-Nab3-Sen1 Zhang, Yinglu 2019 Theses BiologyMolecular biologyBiochemistryRNA polymerasesGenetic transcription
100. The Mechanism of NusG-Mediated Transcription-Translation Coupling and The Role of RacR in Transcription Regulation in Escherichia coli Bailey, Elizabeth Jean 2019 Theses BiochemistryMolecular biologyChemistryGenetic transcription--RegulationEscherichia coli