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806. Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans

Soffer, Gissette; Pavlyha, Marianna; Ngai, Colleen I.; Thomas, Tiffany; Holleran, Stephen F.; Ramakrishnan, Rajasekhar; Karmally, Wahida; Nandakumar, Renu; Fontanez, Nelson; Obunike, Joseph; Marcovina, Santica M.; Lichtenstein, Alice H.; Matthan, Nirupa R.; Matta, James; Maroccia, Magali; Becue, Frederic; Poitiers, Franck; Swanson, Brian; Cowan, Lisa; Sasiela, William J.; Surks, Howard K.; Ginsberg, Henry N.
2017
Articles
Lipoproteins--MetabolismProprotein convertasesLipoprotein AMonoclonal antibodiesMedicine

808. Endothelial progenitor cells in chronic obstructive pulmonary disease and emphysema

Doyle, Margaret F.; Tracy, Russell P.; Parikh, Megha A.; Hoffman, Eric A.; Shimbo, Daichi; Austin, John H. M.; Smith, Benjamin M.; Hueper, Katja; Vogel-Claussen, Jens; Lima, Joao; Gomes, Antoinette; Watson, Karol; Kawut, Steven; Barr, R. Graham
2017
Articles
Endothelial cellsStem cellsLungs--Diseases, ObstructiveEmphysema, PulmonaryMedicine

810. Functional vascularized lung grafts for lung bioengineering

Dorrello, Nicolino Valerio; Guenthart, Brandon A.; O'Neill, John David; Kim, Jinho; Cunningham, Katherine; Chen, Ya-Wen; Biscotti, Mauer; Swayne, Theresa C.; Wobma, Holly Michelle; Huang, Sarah X. L.; Snoeck, Hans-Willem; Bacchetta, Matthew; Vunjak-Novakovic, Gordana
2017
Articles
BioengineeringLungs--Diseases--TreatmentVascular graftsBiomedical engineeringLungsMedicine

811. GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway

Kiryluk, Krzysztof; Li, Yifu; Moldoveanu, Zina; Suzuki, Hitoshi; Reily, Colin; Hou, Ping; Xie, Jingyuan; Mladkova, Nikol; Prakash, Sindhuri; Fischman, Clara; Shapiro, Samantha; LeDesma, Robert A.; Bradbury, Drew; Ionita-Laza, Iuliana; Eitner, Frank; Rauen, Thomas; Maillard, Nicolas; Berthoux, Francois; Floege, Jürgen; Chen, Nan; Zhang, Hong; Scolari, Francesco; Julian, Bruce A.; Wyatt, Robert J.; Gharavi, Ali G.; Novak, Jan
2017
Articles
GlycosylationIgA glomerulonephritisKidneys--DiseasesMolecular biologyBiochemistryMedicine

813. Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function

Joseph, Leroy C.; Kokkinaki, Dimitra; Valenti, Mesele-Christina; Kim, Grace J.; Barca, Emanuele; Tomar, Dhanendra; Hoffman, Nicholas E.; Subramanyam, Prakash; Colecraft, Henry M.; Hirano, Michio; Ratner, Adam Jonathan; Madesh, Muniswamy; Drosatos, Konstantinos; Morrow, John
2017
Articles
CardiologyMyocardium--DiseasesMedicineSepticemiaNAD(P)H dehydrogenasesMitochondrial pathology

824. Pulmonary vascular volume, impaired left ventricular filling and dyspnea: The MESA Lung Study

Aaron, Carrie P.; Hoffman, Eric A.; Lima, Joao A. C.; Kawut, Steven M.; Bertoni, Alain G.; Vogel-Claussen, Jens; Habibi, Mohammadali; Hueper, Katja; Jacobs Jr., David R.; Kalhan, Ravi; Michos, Erin D.; Post, Wendy S.; Prince, Martin R.; Smith, Benjamin M.; Ambale Venkatesh, Bharath; Liu, Chia-Ying; Zemrak, Filip; Watson, Karol; Budoff, Matthew; Bluemke, David A.; Barr, R. Graham
2017
Articles
DyspneaLungs--Blood-vesselsEmphysema, PulmonaryMedicine

825. Revised Hammersmith Scale for spinal muscular atrophy: A SMA specific clinical outcome assessment tool

Ramsey, Danielle; Scoto, Mariacristina; Mayhew, Anna; Main, Marion; Mazzone, Elena S.; Montes, Jacqueline; de Sanctis, Roberto; Salazar, Rachel; Young, Sally Dunaway; Glanzman, Allan M.; Pasternak, Amy; Quigley, Janet; Mirek, Elizabeth; Duong, Tina; Gee, Richard; Civitello, Matthew; Tennekoon, Gihan; Pane, Marika; Pera, Maria Carmela; Bushby, Kate; Day, John; Darras, Basil T.; De Vivo, Darryl C.; Finkel, Richard; Mercuri, Eugenio; Muntoni, Francesco
2017
Articles
PsychometricsSpinal muscular atrophyNeurosciencesMedicine

828. Sieve analysis of breakthrough HIV-1 sequences in HVTN 505 identifies vaccine pressure targeting the CD4 binding site of Env-gp120

deCamp, Allan C.; Rolland, Morgane; Edlefsen, Paul T.; Sanders-Buell, Eric; Hall, Breana; Magaret, Craig A.; Fiore-Gartland, Andrew J.; Juraska, Michal; Carpp, Lindsay N.; Karuna, Shelly T.; Bose, Meera; LePore, Steven; Miller, Shana; O’Sullivan, Annemarie; Poltavee, Kultida; Bai, Hongjun; Dommaraju, Kalpana; Zhao, Hong; Wong, Kim; Chen, Lennie; Ahmed, Hasan; Goodman, Derrick; Tay, Matthew Z.; Gottardo, Raphael; Koup, Richard A.; Bailer, Robert; Mascola, John R.; Graham, Barney S.; Roederer, Mario; O’Connell, Robert J.; Michael, Nelson L.; Robb, Merlin L.; Adams, Elizabeth; D’Souza, Patricia; Kublin, James G.; Corey, Lawrence; Geraghty, Daniel E.; Frahm, Nicole; Tomaras, Georgia D.; McElrath, M. Juliana; Frenke, Lisa; Styrchak, Sheila; Tovanabutra, Sodsai; Sobieszczyk, Magdalena; Hammer, Scott M.; Kim, Jerome H.; Mullins, James I.; Gilbert, Peter B.
2017
Articles
HIV (Viruses)--PreventionMedicineVaccines--ResearchImmune response--Molecular aspects

832. Variability in objective and subjective measures affects baseline values in studies of patients with COPD

Anderson, Wayne; Ha, Jae Wook; Couper, David J.; O’Neal, Wanda K.; Barr, R. Graham; Bleecker, Eugene R.; Carretta, Elizabeth E.; Cooper, Christopher B.; Doerschuk, Claire M.; Drummond, M. Bradley; Han, MeiLan K.; Hansel, Nadia N.; Kim, Victor; Kleerup, Eric C.; Martinez, Fernando J.; Rennard, Stephen I.; Tashkin, Donald; Woodruff, Prescott G.; Paine III, Robert; Curtis, Jeffrey L.; Kanner, Richard E.; SPIROMICS Research Group
2017
Articles
Lungs--Diseases, ObstructiveDiagnosisPulmonary function testsMedicine

839. EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment

Gu, Chao-Jiang; Borjabad, Alejandra; Hadas, Eran; Kelschenbach, Jennifer; Kim, Boe-Hyun; Chao, Wei; Arancio, Ottavio; Suh, Jin; Polsky, Bruce; McMillan, JoEllyn; Edagwa, Benson; Gendelman, Howard E.; Potash, Mary Jane; Volsky, David Julian
2018
Articles
Antiretroviral agentsMacrophagesMild cognitive impairmentMedicineHIV infections

843. Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS

Putcha, Nirupama; Paul, Gabriel G.; Azar, Antoine; Wise, Robert A.; O’Neal, Wanda K.; Dransfield, Mark T.; Woodruff, Prescott G.; Curtis, Jeffrey L.; Comellas, Alejandro; Drummond, M. Bradley; Lambert, Allison A.; Paulin, Laura M.; Fawzy, Ashraf; Kanner, Richard E.; Paine III, Robert; Han, MeiLan K.; Martinez, Fernando J.; Bowler, Russell P.; Barr, R. Graham; Hansel, Nadia N.; SPIROMICS Investigators
2018
Articles
Lungs--Diseases, ObstructiveImmunoglobulin AMedicineImmunodeficiency

844. Lp-PLA2, scavenger receptor class B type I gene (SCARB1) rs10846744 variant, and cardiovascular disease

Manichaikul, Ani; Wang, Xin-Qun; Li, Li; Erdmann, Jeanette; Lettre, Guillaume; Bis, Joshua C.; Waterworth, Dawn; Cushman, Mary; Jenny, Nancy S.; Post, Wendy S.; Palmas, Walter R.; Tsai, Michael Y.; Wallentin, Lars; White, Harvey; Schunkert, Heribert; O’Donnell, Christopher J.; Herrington, David M.; Rich, Stephen S.; O’Donoghue, Michelle L.; Rodriguez, Annabelle
2018
Articles
Cardiovascular system--DiseasesGeneticsInflammationAtherosclerosisMedicine

845. NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis

Tsimikas, Sotirios; Fazio, Sergio; Ferdinand, Keith C.; Ginsberg, Henry N.; Koschinsky, Marlys L.; Marcovina, Santica M.; Moriarty, Patrick M.; Rader, Daniel J.; Remaley, Alan T.; Soffer, Gissette; Santos, Raul D.; Thanassoulis, George; Witztum, Joseph L.; Danthi, Simhan; Olive, Michelle; Liu, Lijuan
2018
Articles
Cardiovascular system--Diseases--Risk factorsCardiovascular system--Diseases--ResearchAortic valve--StenosisLipoprotein AMedicine

847. Performance of the BioPlex 2200 HIV Ag-Ab assay for identifying acute HIV infection

Eshleman, Susan H.; Piwowar-Manning, Estelle; Sivay, Mariya V.; Debevec, Barbara; Veater, Stephanie; McKinstry, Laura A.; Bekker, Linda-Gail; Mannheimer, Sharon B.; Grant, Robert M.; Chesney, Margaret A.; Coates, Thomas J.; Koblin, Beryl A.; Fogel, Jessica M.
2018
Articles
HIV infections--DiagnosisHIV (Viruses)--TestingHIV (Viruses)Medicine

848. Predicting response to checkpoint inhibitors in melanoma beyond PD-L1 and mutational burden

Morrison, Carl; Pabla, Sarabjot; Conroy, Jeffrey M.; Nesline, Mary K.; Glenn, Sean T.; Dressman, Devin; Papanicolau-Sengos, Antonios; Burgher, Blake; Andreas, Jonathan; Giamo, Vincent; Qin, Moachun; Wang, Yirong; Lenzo, Felicia L.; Omilian, Angela; Bshara, Wiam; Zibelman, Matthew; Ghatalia, Pooja; Dragnev, Konstantin; Shirai, Keisuke; Madden, Katherine G.; Tafe, Laura J.; Shah, Neel; Kasuganti, Deepa; de la Cruz-Merino, Luis; Araujo, Isabel; Saenger, Yvonne M.; Bogardus, Margaret; Villalona-Calero, Miguel; Diaz, Zuanel; Day, Roger; Eisenberg, Marcia; Anderson, Steven M.; Puzanov, Igor; Galluzzi, Lorenzo; Gardner, Mark; Ernstoff, Marc S.
2018
Articles
Melanoma--TreatmentCancer--ImmunotherapyBiochemical markersMedicine

849. Prioritizing the needs of children in a changing climate

Stanberry, Lawrence Raymond; Thomson, Madeleine C.; James, Wilmot Godfrey
2018
Articles
Children--Health and hygieneClimatic changes--Health aspectsEnvironmental healthPediatricsMedicineCommunicable diseases--Prevention

852. Risk behaviors and HIV care continuum outcomes among criminal justice-involved HIV-infected transgender women and cisgender men: Data from the Seek, Test, Treat, and Retain Harmonization Initiative

Beckwith, Curt G.; Kuo, Irene; Fredericksen, Rob J.; Brinkley-Rubinstein, Lauren; Cunningham, William E.; Springer, Sandra A.; Loeliger, Kelsey B.; Franks, Julie C.; Christopoulos, Katerina; Lorvick, Jennifer; Kahana, Shoshana Y.; Young, Rebekah; Seal, David W.; Zawitz, Chad; Delaney, Joseph A.; Crane, Heidi M.; Biggs, Mary L.
2018
Articles
HIV-positive persons--CareMedicineTransgender peopleContinuum of carePrisoners--Health and hygiene

853. The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of non-small cell lung cancer (NSCLC)

Brahmer, Julie R.; Govindan, Ramaswamy; Anders, Robert A.; Antonia, Scott J.; Sagorsky, Sarah; Davies, Marianne J.; Dubinett, Steven M.; Ferris, Andrea; Gandhi, Leena; Garon, Edward B.; Hellmann, Matthew D.; Hirsch, Fred R.; Malik, Shakuntala; Neal, Joel W.; Papadimitrakopoulou, Vassiliki A.; Rimm, David L.; Schwartz, Lawrence H.; Sepesi, Boris; Yeap, Beow Y.; Rizvi, Naiyer A.; Herbst, Roy S.
2018
Articles
Cancer--ImmunotherapyLungs--CancerMedicineConsensus (Social sciences)

856. Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock The ANDROMEDA-SHOCK Randomized Clinical Trial

Hernandez, Glenn; Ospina‑Tascón, Gustavo; Damiani, Lucas Petri; Estenssoro, Elisa; Dubin, Arnaldo; Hurtado, F. Javier; Friedman, Gilberto; Castro, Ricardo; Alegría, Leyla; Teboul, Jean-Louis; Cecconi, Maurizio; Ferri, Giorgio; Jibaja, Manuel; Pairumani, Ronald; Fernández, Paula; Barahona, Diego; Granda-Luna, Vladimir; Cavalcanti, Alexandre Biasi; Bakker, Jan; The ANDROMEDA-SHOCK Study Investigators; Latin-American Intensive Care Network - LIVEN
2019
Articles
Critical care medicineSeptic shockResuscitationMedicine

858. Effects of APOC3 Heterozygous Deficiency on Plasma Lipid and Lipoprotein Metabolism.

Soffer, Gissette; Sztalryd, Carol; Horenstein, Richard B.; Holleran, Stephen F.; Matveyenko, Anastasiya; Thomas, Tiffany; Nandakumar, Renu; Ngai, Colleen I.; Karmally, Wahida; Ginsberg, Henry N.; Ramakrishnan, Rajasekhar; Pollin, Toni I.
2019
Articles
Cardiovascular system--DiseasesCardiovascular system--Diseases--Risk factorsApolipoproteinsBlood lipidsBlood lipoproteins--MetabolismMedicine

861. Validation of Melanoma Immune Profile (MIP), a Prognostic Immune Gene Prediction Score for Stage II–III Melanoma

Gartrell, Robyn D.; Marks, Douglas K.; Rizk, Emanuelle M.; Bogardus, Margaret Haskell; Gérard, Camille L.; Barker, Luke William; Fu, Yichun; Esancy, Camden L.; Li, Gen; Ji, Jiayi; Rui, Shumin; Ernstoff, Marc S.; Taback, Bret; Pabla, Sarabjot; Chang, Rui; Lee, Sandra J.; Krolewski, John J.; Morrison, Carl; Horst, Basil; Saenger, Yvonne M.
2019
Articles
MelanomaMelanoma--Immunological aspectsMelanoma--Genetic aspectsBiometryMedicine

863. T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer

Obradovic, Aleksandar Zoran; Dallos, Matthew C.; Zahurak, Marianna L.; Partin, Alan W.; Schaeffer, Edward M.; Ross, Ashley E.; Allaf, Mohamad E.; Nirschl, Thomas R.; Chapman, Carolyn G.; O'Neal, Tanya; Cao, Haiyi; Durham, Jennifer N.; Guner, Gunes; Baena-Del Valle, Javier A.; Ertunc, Onur; De Marzo, Angelo M.; Antonarakis, Emmanuel S.; Drake, Charles G.
2020
Articles
Prostate--CancerProstate--Cancer--TreatmentCancer--ImmunotherapyCancer vaccinesMedicine

866. Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection

Wong Fok Lung, Tania; Charytonowicz, Daniel; Beaumont, Kristin G.; Shah, Shivang; Sridhar, Shwetha H.; Gorrie, Claire L.; Mu, Andre; Hofstaedter, Casey E.; Varisco, David; McConville, Thomas Howe; Drikic, Marija; Fowler, Brandon; Urso, Andreacarola; Shi, Wei; Fucich, Dario; Annavajhala, Medini; Khan, Ibrahim N.; Oussenko, Irina; Francoeur, Nancy; Smith, Melissa L.; Stockwell, Brent R.; Lewis, Ian A.; Hachani, Abderrahman; Upadhyay Baskota, Swikrity; Uhlemann, Anne-Catrin; Ahn, Danielle; Ernst, Robert K.; Howden, Benjamin P.; Sebra, Robert; Prince, Alice S.
2022
Articles
ImmunosuppressionKlebsiella pneumoniaeLungs--InfectionsNosocomial infectionsMedicine

868. Evidence-Based Assessment of Congenital Heart Disease Genes to Enable Returning Results in a Genomic Study

Griffin, Emily Leann; Nees, Shannon N.; Morton, Sarah U.; Wynn, Julia; Patel, Nihir; Jobanputra, Vaidehi; Robinson, Scott; Kochav, Stephanie M.; Tao, Alice May; Andrews, Carli; Cross, Nancy; Geva, Judith; Lanzilotta, Kristen; Ritter, Alyssa; Taillie, Eileen; Thompson, Alexandra; Meyer, Chris; Akers, Rachel; King, Eileen C.; Cnota, James F.; Kim, Richard W.; Porter, Jr., George A.; Brueckner, Martina; Seidman, Christine E.; Shen, Yufeng; Gelb, Bruce D.; Goldmuntz, Elizabeth; Newburger, Jane W.; Roberts, Amy E.; Chung, Wendy K.
2023
Articles
Congenital heart diseaseGeneticsGenetic screeningMedicine

869. Safety, tolerability, pharmacokinetics, and immunological activity ...

Sobieszczyk, Magdalena E.; Mannheimer, Sharon B.; Paez, Carmen A.; Yu, Chenchen; Gamble, Theresa; Theodore, Deborah Anne; Chege, Wairimu; Yacovone, Margaret; Hanscom, Brett; Heptinstall, Jack; Seaton, Kelly E.; Zhang, Lily; Miner, Maurine D.; Eaton, Amanda; Weiner, Joshua A.; Kalams, Spyros; Stephenson, Kathryn; Julg, Boris; Caskey, Marina; Nussenzweig, Michel; Gama, Lucio; Barouch, Dan H.; Ackerman, Margaret E.; Tomaras, Georgia D.; Montefiori, David; HVTN 130 HPTN 089 Study Team
2023
Articles
Monoclonal antibodiesHIV infections—PreventionClinical trialsMedicine