Academic Unit: Microbiology and Immunology | Search Results

1. An Essential Role for ECSIT in Mitochondrial Complex I Assembly and Mitophagy in Macrophages

: Carneiro, Flávia R.G.; Lepelley, Alice; Seeley, John; Hayden, Matthew S.; Ghosh, Sankar
: 2018
: Articles
: MitochondriaGlycolysisMolecular biologyMacrophagesProteinsCytology

2. Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway

: Chen, Yen-Hua; Kratchmarov, Radomir; Lin, Wen-Hsuan W.; Rothman, Nyanza J.; Yen, Bonnie; Adams, William C.; Nish, Simone A.; Rathmell, Jeffrey C.; Reiner, Steven L.
: 2018
: Articles
: Cell divisionMicrobiologyCell compartmentationCytologyLymphocytes

3. Detection of fungal and bacterial carbohydrates: Do the similar structures of chitin and peptidoglycan play a role in immune dysfunction?

: Dworkin, Jonathan E.
: 2018
: Articles
: ChitinPeptidoglycansCarbohydratesImmune responseMolecular biologyImmunology

4. Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter

: Lee, Andrew H.; Dhingra, Satish Kumar; Lewis, Ian A.; Singh, Maneesh K.; Siriwardana, Amila; Dalal, Seema; Rubiano, Kelly; Klein, Matthias S.; Baska, Katelynn S.; Krishna, Sanjeev; Klemba, Michael; Roepe, Paul D.; Llinás, Manuel; Garcia, Celia R. S.; Fidock, David Armand
: 2018
: Articles
: HemoglobinMalaria--PreventionChloroquinePlasmodium falciparum

5. Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa

: Simam, Joan; Rono, Martin; Ngoi, Joyce; Nyonda, Mary; Mok, Sachel Shu Li; Marsh, Kevin; Bozdech, Zbynek; Mackinnon, Margaret
: 2018
: Articles
: GenomicsPlasmodium falciparumMicrobiologyAdaptation (Biology)

6. Inorganic phosphate, arsenate, and vanadate enhance exonuclease transcript cleavage by RNA polymerase by 2000-fold

: Gottesman, Maxwell E.; Mustaev, Arkady
: 2018
: Articles
: MicrobiologyChemotaxonomyRNA--SynthesisRNA polymerasesPhosphatesVanadatesArsenates

7. Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites

: Rocamora, Frances; Zhu, Lei; Liong, Kek Yee; Dondorp, Arjen; Miotto, Olivo; Mok, Sachel Shu Li; Bozdech, Zbynek
: 2018
: Articles
: ArtemisininMalaria--TreatmentDrug resistanceParasitic diseasesOxidative stressBiology

8. Structure and nucleic acid binding properties of KOW domains 4 and 6–7 of human transcription elongation factor DSIF

: Zuber, Philipp K.; Hahn, Lukas; Reinl, Anne; Schweimer, Kristian; Knauer, Stefan H.; Gottesman, Maxwell E.; Rösch, Paul; Wöhrl, Birgitta M.
: 2018
: Articles
: Nucleic acidsRNA-protein interactionsTranscription factors

9. Viral Entry Properties Required for Fitness in Humans Are Lost through Rapid Genomic Change during Viral Isolation

: Iketani, Sho; Shean, Ryan C.; Ferren, Marion; Makhsous, Negar; Aquino, Dolly B.; des Georges, Amedee; Rima, Bert; Mathieu, Cyrille; Porotto, Matteo; Moscona, Anne; Greninger, Alexander L.
: 2018
: Articles
: BiochemistryImmunologyVirologyNatural selectionParainfluenza virusesMetagenomicsLungs--Infections

10. A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine

: Dhingra, Satish Kumar; Redhi, Devasha; Combrinck, Jill M.; Yeo, Tomas; Okombo, John; Henrich, Philipp P.; Cowell, Annie N.; Gupta, Purva; Stegman, Matthew L.; Hoke, Jonathan M.; Cooper, Roland A.; Winzeler, Elizabeth; Mok, Sachel Shu Li; Egan, Timothy J.; Fidock, David Armand
: 2017
: Articles
: Plasmodium falciparumMicrobiologyAntimalarialsBiology

11. Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites

: Kumar, Brahma Vencel; Ma, Wenji; Miron, Michelle; Granot, Tomer; Guyer, Rebecca S.; Carpenter, Dustin; Senda, Takashi; Sun, Xiaoyun; Ho, Siu-Hong; Lerner, Harvey; Friedman, Amy L.; Shen, Yufeng; Farber, Donna L.
: 2017
: Articles
: T cellsImmunologyNucleotide sequenceLymphoid tissueMucous membrane

12. Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro

: Straimer, Judith; Gnadig, Nina; Stokes, Barbara Hoyt Squeff; Ehrenberger, Michelle; Crane, Audrey A.; Fidock, David Armand
: 2017
: Articles
: Plasmodium falciparumDrug resistanceMicrobiologyArtemisininCommunicable diseases

13. Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells

: Geis, Franziska K.; Galla, Melanie; Hofmann, Dirk; Kuehle, Johannes; Zychlinski, Daniela; Maetzig, Tobias; Schott, Juliane W.; Schwarzer, Adrian; Gofnet, Christine; Goff, Stephen P.; Schambach, Axel
: 2017
: Articles
: LentivirusesStem cellsPeptidylprolyl isomeraseRetroviruses

14. Single locus genotyping to track Leishmania donovani in the Indian subcontinent: Application in Nepal

: Rai, Keshav; Bhattara, Narayan Raj; Vanaerschot, Manu; Imamura, Hideo; Gebru, Gebreyohans; Khanal, Basudha; Rijal, Suman; Boelaer, Marleen; Pal, Chiranjib; Kark, Prahlad; Dujardin, Jean-Claude; Van der Auwera, Gert
: 2017
: Articles
: LeishmaniaEpidemiologyNucleotide sequenceGenetics

15. A computational interactome and functional annotation for the human proteome

: Garzon Canas, Jose I.; Deng, Lei; Murray, Diana; Shapira, Sagi; Petrey, Donald S.; Honig, Barry
: 2016
: Articles
: Computational biologyProteomicsProtein-protein interactionsSystems biology

16. A High-Throughput Strategy for Dissecting Mammalian Genetic Interactions

: Stockman, Victoria B.; Ghamsari, Lila; Lasso Cabrera, Gorka; Honig, Barry; Shapira, Sagi; Wang, Harris H.
: 2016
: Articles
: RNAMammals--Molecular geneticsNucleotide sequenceSystems biologyMolecular geneticsCloningGeneticsBiology--Classification

17. Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling

: Le Bihan, Amélie; de Kanter, Ruben; Angulo-Barturen, Iñigo; Binkert, Christoph; Boss, Christoph; Brun, Reto; Brunner, Ralf; Buchmann, Stephan; Burrows, Jeremy; Dechering, Koen J.; Delves, Michael; Ewerling, Sonja; Fischli, Christoph; Ferrer, Santiago; Gamo–Benito, Francisco Javier; Gnädig, Nina; Heidmann, Bibia; Jiménez-Díaz, María Belén; Leroy, Didier; Martínez, Maria Santos; Meyer, Solange; Moehrle, Joerg J.; Ng, Caroline; Noviyanti, Rintis; Ruecker, Andrea; Sanz, Laura María; Sauerwein, Robert W.; Scheurer, Christian; Schleiferboeck, Sarah; Sinden, Robert; Snyder, Christopher; Straimer, Judith; Wirjanata, Grennady; Marfurt, Jutta; Price, Ric N.; Fischli, Walter; Weller, Thomas; Fidock, David Armand; Clozel, Martine; Wittlin, Sergio
: 2016
: Articles
: Drug resistanceArtemisininAntimalarialsVirology

18. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9

: Lee, Linda M.; Ji, Ming; Sinha, Meenal; Dong, Matthew B.; Ren, Xin; Wang, Yanli; Lowell, Clifford A.; Ghosh, Sankar; Locksley, Richard M.; DeFranco, Anthony L.
: 2016
: Articles
: ImmunopathologyImmune responseLigandsCytokines--ImmunologyInflammation--Immunological aspectsT cellsMedicineImmunology

19. Evidence of a Mild Mutator Phenotype in Cambodian Plasmodium falciparum Malaria Parasites

: Lee, Andrew H.; Fidock, David Armand
: 2016
: Articles
: Drug resistance in microorganismsPlasmodium falciparumMalariaMutation (Biology)GeneticsMolecular biologyParasitology

20. Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

: Gabryszewski, Stanislaw J.; Dhingra, Satish Kumar; Combrinck, Jill M.; Lewis, Ian A.; Callaghan, Paul S.; Hassett, Matthew R.; Siriwardana, Amila; Henrich, Philipp P.; Lee, Andrew H.; Gnadig, Nina; Musset, Lise; Llinás, Manuel; Egan, Timothy J.; Roepe, Paul D.; Fidock, David Armand
: 2016
: Articles
: Drug resistance in microorganismsChloroquineDrugs--MetabolismPlasmodium falciparumPathologyImmunology

21. mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2

: Kim, Kyeong Jin; Qiang, Li; Hayden, Matthew S.; Sparling, David P.; Purcell, Nicole H.; Pajvani, Utpal B.
: 2016
: Articles
: Fatty degenerationCells--Growth--RegulationLiver--DiseasesImmunologyMedicineMolecular biology

22. Restriction of HIV-1-based lentiviral vectors in adult primary marrow-derived and peripheral mobilized human CD34+ hematopoietic stem and progenitor cells occurs prior to viral DNA integration

: Griffin, Daniel; Goff, Stephen P.
: 2016
: Articles
: Gene therapyLentivirusesStem cellsHIV infectionsMolecular biology

23. Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms

: Hatai, Hirotsugu; Lepelley, Alice; Zeng, Wangyong; Hayden, Matthew S.; Ghosh, Sankar
: 2016
: Articles
: Immune response--Molecular aspectsToxoplasma gondiiProtozoan diseasesImmunologyMicrobiologyPathology

24. E2-2 Dependent Plasmacytoid Dendritic Cells Control Autoimmune Diabetes

: Hansen, Lisbeth; Schmidt-Christensen, Anja; Gupta, Shashank; Fransén-Pettersson, Nina; Hannibal, Tine D.; Reizis, Boris; Santamaria, Pere; Holmberg, Dan
: 2015
: Articles
: Dendritic cellsIslands of LangerhansDiabetes--PreventionDiabetesMedicineImmunology

25. MHC Class I Expression by Donor Hematopoietic Stem Cells Is Required to Prevent NK Cell Attack in Allogeneic, but Not Syngeneic Recipient Mice

: Hirata, Yuichi; Li, Hao Wei; Takahashi, Kazuko; Ishii, Hiroshi; Sykes, Megan; Fujisaki, Joji
: 2015
: Articles
: Cell differentiationHematopoietic stem cellsMajor histocompatibility complexBone marrow cellsKiller cellsMedicine

26. Nuclear matrix protein Matrin 3 is a regulator of ZAP-mediated retroviral restriction

: Erazo, Angela; Goff, Stephen P.
: 2015
: Articles
: Gene expressionNuclear matrixRetrovirusesAntiretroviral agentsMolecular biologyBiochemistry

27. Regulation of Transcription Elongation and Termination

: Washburn, Robert; Gottesman, Max E.
: 2015
: Articles
: Genetic transcriptionBiomoleculesBiomolecules--StructureMicrobiology

28. Asynchronous Transcriptional Silencing of Individual Retroviral Genomes in Embryonic Cells

: Schlesinger, Sharon; Meshorer, Eran; Goff, Stephen P.
: 2014
: Articles
: CytologyGeneticsVirology

29. CRISPR-mediated genome editing of Plasmodium falciparum malaria parasites

: Lee, Marcus C. S.; Fidock, David Armand
: 2014
: Articles
: GenomicsMalaria--TreatmentMalaria--PreventionBiochemistry

30. Electrochemical Regulation of Budding Yeast Polarity

: Haupt, Armin; Campetelli, Alexis; Bonazzi, Daria; Piel, Matthieu; Chang, Fred; Minc, Nicolas
: 2014
: Articles
: Polarization (Electricity)Organic electrochemistryCytochemistrySaccharomyces cerevisiaeCytology

31. How and why cells grow as rods

: Chang, Fred; Huang, Kerwyn
: 2014
: Articles
: CytologyMorphogenesisMolecular biology

32. Major and Minor Group Rhinoviruses Elicit Differential Signaling and Cytokine Responses as a Function of Receptor-Mediated Signal Transduction

: Schruler, Bruce A.; Schreiber, Michael Thomas; Li, LuYuan; Mokry, Michael; Kingdon, Megan L.; Raugi, Dana N.; Smith, Cosonya; Hameister, Chelsea; Racaniello, Vincent R.
: 2014
: Articles
: CytokinesCytokines--ImmunologyMedical virologyAsthma--PathophysiologyRhinovirusesVirologyMicrobiology

33. Modeling Within-Host Effects of Drugs on Plasmodium falciparum Transmission and Prospects for Malaria Elimination

: Johnston, Geoffrey L.; Gething, Peter W.; Hay, Simon I.; Smith, David L.; Fidock, David Armand
: 2014
: Articles
: MalariaParasitic diseasesGerm cellsImmunology

34. An integrated strategy for efficient vector construction and multi-gene expression in Plasmodium falciparum

: Wagner, Jeffrey; Goldfless, Stephen; Ganesan, Suresh; Lee, Marcus; Fidock, David Armand; Niles, Jacquin
: 2013
: Articles
: Transgenes--ExpressionMalaria--Immunological aspectsGeneticsMicrobiology

35. A Role for NF-κB Activity in Skin Hyperplasia and the Development of Keratoacanthomata in Mice

: Poligone, Brian; Hayden, Matthew S.; Chen, Luojing; Pentland, Alice P.; Jimi, Eijiro; Ghosh, Sankar
: 2013
: Articles
: NF-kappa B (DNA-binding protein)HyperplasiaMice as laboratory animalsKeratoacanthomaMedical sciencesDermatologyOncology

36. Interleukin 15 Primes Natural Killer Cells to Kill via NKG2D and cPLA2 and This Pathway Is Active in Psoriatic Arthritis

: Tang, Fangming; Sally, Benjamin Andrew; Ciszewski, Cezary; Abadie, Valerie; Curran, Shane A.; Groh, Veronika; FitzGerald, Oliver; Winchester, Robert J.; Jabri, Bana
: 2013
: Articles
: Killer cellsInterleukinsPsoriatic arthritisMedicineImmunology

37. Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families

: Bopp, Selina E. R.; Manary, Micah J.; Bright, A. Taylor; Chi-Johnston, Geoffrey Louis; Dharia, Neekesh V.; Luna, Fabio L.; McCormack, Susan; Plouffe, David; McNamara, Case W.; Walker, John R.; Fidock, David Armand; Denchi, Eros Lazzerini; Winzeler, Elizabeth A.
: 2013
: Articles
: MicrobiologyImmunologyGeneticsPlasmodium

38. The Kinase PDK1 Is Essential for B-Cell Receptor Mediated Survival Signaling

: Park, Sung-Gyoo; Long, Meixiao; Kang, Jung-Ah; Kim, Woo-Seok; Lee, Cho-Rong; Im, Sin-Hyeog; Strickland, Ian; Schulze-Luehrmann, Jan; Hayden, Matthew S.; Ghosh, Sankar
: 2013
: Articles
: Protein kinasesB cellsT cells--ReceptorsCellular signal transduction

39. A new world malaria map: Plasmodium falciparum endemicity in 2010

: Gething, Peter; Patil, Anand; Smith, David; Guerra, Carlos; Elyazar, Iqbal; Johnston, Geoffrey L.; Tatem, Andrew; Hay, Simon
: 2011
: Articles
: Medical mappingMalaria--EpidemiologyPlasmodium falciparumPublic healthEpidemiologyPathology

40. SUMO-Interacting Motifs of Human TRIM5α are Important for Antiviral Activity

: Arriagada, Gloria; Muntean, Lucia N.; Goff, Stephen P.
: 2011
: Articles
: MicrobiologyVirologyMolecular biology

41. Abl Family Tyrosine Kinases Are Essential for Basement Membrane Integrity and Cortical Lamination in the Cerebellum

: Qiu, Zhaozhu; Cang, Yong; Goff, Stephen P.
: 2010
: Articles
: Molecular biologyNeurosciencesMicrobiology

42. Interactions of Host Proteins with the Murine Leukemia Virus Integrase

: Studamire, Barbara; Goff, Stephen P.
: 2010
: Articles
: PathologyMolecular biologyBiochemistry

43. Gemfibrozil Inhibits Legionella pneumophila and Mycobacterium tuberculosis Enoyl Coenzyme A Reductases and Blocks Intracellular Growth of These Bacteria in Macrophages

: Reich-Slotky, Ronit; Kabbash, Christina A.; Della-Latta, Phyllis; Blanchard, John S.; Feinmark, Steven Jay; Freeman, Sherry; Kaplan, Gilla; Shuman, Howard A.; Silverstein, Samuel C.
: 2009
: Articles
: Multidrug-resistant tuberculosisIntracellular pathogensLegionella pneumophilaBiochemistryMicrobiologyMolecular biology

44. Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

: Dharia, Neekesh; Sidhu, Amar; Cassera, María; Westenberger, Scott; Bopp, Selina; Eastman, Rich; Plouffe, David; Batalov, Serge; Park, Daniel; Volkman, Sarah; Wirth, Dyann; Zhou, Yingyao; Fidock, David Armand; Winzeler, Elizabeth
: 2009
: Articles
: GeneticsImmunologyPlasmodium falciparum

45. Backward Genotype-Trait Association (BGTA)-Based Dissection of Complex Traits in Case-Control Designs

: Zheng, Tian; Wang, Hui; Lo, Shaw-Hwa
: 2006
: Articles
: StatisticsGeneticsBiometry

46. TRIM5α selectively binds a restriction-sensitive retroviral capsid

: Sebastian, Sarah; Luban, Jeremy
: 2005
: Articles
: Protein bindingRetroviruses--EnzymesVirologyMicrobiology

47. Endophilins interact with Moloney murine leukemia virus Gag and modulate virion production

: Wang, Margaret; Kim, Wankee; Gao, Guangxia; Torrey, Ted; Morse, Herbert; De Camilli, Pietro; Goff, Stephen P.
: 2003
: Articles
: Molecular biologyVirology

48. Endophilins Interact with Moloney Murine Leukemia Virus Gag and Modulate Virion Production.

: Wang, Margaret Q.; Kim, Wankee; Gao, Guangxia; Morse, Herbert C.; De Camilli, Pietro; Goff, Stephen P.; Torrey, Ted A.
: 2003
: Articles
: Molecular biologyOncologyVirology

49. The Thrombopoietin Receptor Can Mediate Proliferation Without Activation of the Jak-STAT Pathway

: Dorsch, Marion; Fan, Pang-Dian; Danial, Nika N.; Rothman, Paul B.; Goff, Stephen P.
: 1997
: Articles
: Molecular biologyBiochemistryMedicine

50. Abl-interactor-1, A Novel SH3 Protein Binding to the Carboxy-terminal Portion of the Abl Protein, Suppresses v-abl Transforming Activity

: Shi, Yanggu; Alin, Kimona; Goff, Stephen P.
: 1995
: Articles
: CytologyGeneticsVirology

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