1. Discovery and Optimization of Novel Small-Molecule Inhibitors of Glutathione Peroxidase 4 Lin, Annie 2023 Theses BiologyDrug resistance in cancer cellsCell deathGlutathioneCancer cells--Effect of drugs on
2. Genetic Variant Effects on Transcription Factor Regulation Li, Xiaoting 2023 Theses BiologyHuman genetics--VariationDiseases--Risk factorsHuman genomeGenomicsGenetic transcriptionGene expression
3. Regulation of EGFR signal transduction and cell division in quiescent Vulval Precursor Cells during dauer developmental arrest O'Keeffe, Catherine 2023 Theses BiologyDevelopmental biologyCaenorhabditis elegansStem cellsVulvaCell division
4. The Role of Kinesins in Cell Fate Determination During Neurogenesis Helmer, Paige 2023 Theses BiologyKinesinNeurogeneticsNeuronsBrain--PhysiologyMammals--Nervous systemNeuroglia
5. Auditory Tuning in Vocal Learning Songbirds Yeh, Yow-Tyng 2022 Theses BiologyNeurosciencesSongbirdsBirds--VocalizationBirdsongsSensorimotor cortex
6. Cardiomyopathy at the Intersection of Stem Cells and Tissue Engineering Wang, Bryan Zicheng 2022 Theses BiologyMyocardium--DiseasesStem cellsGene editingTissue engineeringHeart--Diseases--Genetic aspects
7. Development of genetically intact bioengineered spores of Bacillus subtilis Flores Quijano, Juan Manuel de Jesus 2022 Theses BiologyBacillus subtilis--GeneticsPlasmids--GeneticsBiotechnologyNatural pesticidesProbiotics
8. Expression and Functional Analyses of the Entire Cadherin Gene Family in C. elegans Majeed, Maryam 2022 Theses BiologyNeurosciencesCaenorhabditis elegans--GeneticsGene expressionCadherins
9. Understanding and Engineering Multicomponent Living Systems: Examples from Synthetic Genomics and Engineered Living Materials McBee, Andrew Ross MacKay 2022 Theses BiologySynthetic biologyGenomicsMetazoaAmino acidsValineMycelium
10. A Comparative Analysis of Genome Rearrangement in Ciliates Feng, Yi 2021 Theses BiologyBioinformaticsEvolution (Biology)Gene rearrangementCiliata--GeneticsEuplotesGenetic code
11. Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements Murphy, David 2021 Theses GeneticsEvolution (Biology)BiologyHuman genomeBiodiversity
12. Disentangling mutation and selection in human genetic variation: promises and pitfalls Agarwal, Ipsita 2021 Theses BiologyGeneticsEvolution (Biology)Mutation (Biology)Human genomeExomes
13. Electromechanical Coupling in Cells and Its Effects on Membrane Tension and Conductance Jones Molina, John Anthony 2021 Theses BiophysicsCytologyBiologyCell membranes
14. Framework for Mapping Gene Regulation via Single-cell Genetic Screens Tan, Xiangtian 2021 Theses BiologyCytologyGenetic transcription--RegulationCancer cellsProteins--Analysis
15. Function and Regulation of ALS/FTD-associated RNA Binding Protein FUS Tsai, Yueh-Lin 2021 Theses BiologyCytologyMolecular biologyRNA-protein interactionsAmyotrophic lateral sclerosisDementia
16. Mutagenic Repair Outcomes of DNA Double-Strand Breaks Al-Zain, Amr M. 2021 Theses BiologyMolecular biologyDouble-stranded RNACancer--EtiologyCancer--Genetic aspectsGenomesMutagenesis
17. Novel Functions for Dynein Adaptor RILP in Neuronal Autophagy Khobrekar, Noopur V. 2021 Theses BiologyBiochemistryDyneinAutophagic vacuolesCell organelles
18. Regulation of heterochromatin formation by the JmjC-domain protein Epe1 Bao, Kehan 2021 Theses BiologyEukaryotic cells--GeneticsHeterochromatinChromatinDNA
19. Role of Mu-Opioid Receptors in the Behavioral Effects of the Antidepressant Tianeptine Han, Jaena 2021 Theses BiologyNeurosciencesDepression, Mental--TreatmentAntidepressantsSerotonin uptake inhibitorsMice
20. Structural Studies of NediV-IRES-Mediated Translation Initiation Altomare, Clara Gilda 2021 Theses BiologyVirusesRNA virusesRibosomesEukaryotic cellsGenetic translation
21. Ultrastructural analysis of dendritic spine necks reveals a continuum of spine morphologies: Models Ofer, Netanel; Yuste, Rafael 2021 Data (Information) NeuronsUltrastructure (Biology)BiologyNeurosciences
22. Adipocytes Secrete Lipid-Laden Exosomes and Influence Local Macrophage Behavior Flaherty, Stephen 2020 Theses BiologyLipaseMacrophagesFat cellsAdipose tissues--Analysis
23. Elucidating the abilities of MDM2, MDMX and p21 to regulate ferroptosis Venkatesh, Divya 2020 Theses BiologyGeneticsLipids--PeroxidationCell deathCancer
24. Hierarchical Modularity in the Reassembly of Hydra’s Nervous System Lovas, Jonathan Roek 2020 Theses NeurosciencesDevelopmental biologyBiologyHydraNeural circuitry
25. Landscape of the p53 transcriptome and clinical implications Regunath, Kausik 2020 Theses BiologyGenomesCancer--Genetic aspectsTumors
26. Light and Temperature Cues Elicit Metabolic Reprogramming in the Non-phototrophic Bacterium Pseudomonas aeruginosa Kahl, Lisa Juliane 2020 Theses BiologyMicrobiologyMetabolismBiological rhythmsPhotobiologyBacteria--PhysiologyRespiration
27. Predicting Autonomous Promoter Activity Based on Genome-wide Modeling of Massively Parallel Reporter Data FitzPatrick, Vincent Drury 2020 Theses BiologyStatisticsPromoters (Genetics)Genomics--Statistical methodsGenetic polymorphisms
28. Screening Whole-Genome Sequenced Strains to Investigate Genetic Determinants of Gentle Touch Sensitivity in Caenorhabditis elegans Lawry, Stephanie Terese 2020 Theses GeneticsBiologyGenomicsGenomesNematodesTouchNeurosciences
29. Sexually Dimorphic Development of the Caenorhabditis elegans Nervous System Bayer, Emily Ann 2020 Theses BiologyCaenorhabditis elegansSexual dimorphism (Animals)Genetic sex determinationTranscription factorsNervous system
30. Single-particle cryo-electron microscopy studies of ribosomes with fragmented 28S rRNA Gutierrez-Vargas, Cristina 2020 Theses BiologyStructural bioinformaticsRibosomes--StructureRNATrypanosoma cruziFragmentation reactions
31. The Neural Basis of Sugar and Fat Cravings Tan, Hwei-Ee 2020 Theses NeurosciencesBiologySugarGlucoseFatAppetite
32. Applying medicinal chemistry principles to the Olfactory Code Tahirova, Narmin Tahir 2019 Theses BiologyNeurosciencesChemistryOlfactory receptorsPharmaceutical chemistry
33. Computational and Imaging Methods for Studying Neuronal Populations during Behavior Han, Shuting 2019 Theses BiologyNeurosciencesMachine learningBrain--ImagingNeuropsychiatryAnimal behaviorNeurons
34. Life history effects on neutral polymorphism and divergence rates, in autosomes and sex chromosomes Amster, Guy 2019 Theses BiologySex chromosomesGenetic polymorphismsPopulation geneticsChromosomesBiodiversity
35. Mapping the whole-body muscle activity of Hydra vulgaris Szymanski, John Robert; Yuste, Rafael 2019 Data (Information) BiologyHydraMusclesEvolution (Biology)
36. Novel functions of C9ORF72, a gene involved in ALS/FTD Fomin, Vitalay 2019 Theses BiologyBiochemistryGeneticsCytologyAmyotrophic lateral sclerosisFrontotemporal dementiaGene expression
37. Population Genetics of Mutation Load and Quantitative Traits in Humans Simons, Yuval Benjamin 2019 Theses GeneticsBiologyHuman population geneticsMutation (Biology)
38. Quantifying spatiotemporal dynamics of human gut microbiota and metabolic limitations of cancer cell growth Ji, Brian 2019 Theses BiologyBiological systemsCancer cells--Growth--RegulationGastrointestinal system--MicrobiologyCell metabolism
39. Quantitative trait variation and adaptation in contemporary humans Mostafavi, Hakhamanesh 2019 Theses BiologyGeneticsHuman evolutionGenomes--Data processingHuman genetics--VariationMortality
40. Structural studies of the yeast transcription termination complex Nrd1-Nab3-Sen1 Zhang, Yinglu 2019 Theses BiologyMolecular biologyBiochemistryRNA polymerasesGenetic transcription
41. Studies on RNA Regulation: From Enhancer RNAs to RBBP6 Isoform3 Chen, Yaqiong 2019 Theses Molecular biologyRNAGenetic regulationBiology
42. Allosteric Coupling, Nucleotide Binding and ATP Hydrolysis by Hsp70 Chaperones on a Structural Basis Wang, Wei 2018 Theses BiologyBiochemistryBiophysicsAllosteric regulationHeat shock proteins
43. An atlas of Caenorhabditis elegans chemoreceptor expression Iglesias, Berta Vidal; Aghayeva, Ulkar; Sun, Haosheng; Wang, Chen; Glenwinkel, Lori Ann; Bayer, Emily Ann; Hobert, Oliver 2018 Articles Caenorhabditis elegansChemoreceptorsNeurosciencesBiology
44. A population genetic interpretation of GWAS findings for human quantitative traits Simons, Yuval Benjamin; Bullaughey, Kevin; Hudson, Richard R.; Sella, Guy 2018 Articles GeneticsPhenotypeBiologyHuman genome
45. cis-regulatory architecture of a short-range EGFR organizing center in the Drosophila melanogaster leg Newcomb, Susan Elizabeth; Voutev, Roumen; Jory, Aurelie E.; Delker, Rebecca; Slattery, Matthew; Mann, Richard S. 2018 Articles Drosophila melanogaster--GeneticsGrowth factors--ReceptorsCloningBiologyGene expression
46. Comprehensive machine learning analysis of Hydra behavior reveals a stable basal behavioral repertoire Han, Shuting; Taralova, Ekaterina; Dupre, Christophe; Yuste, Rafael 2018 Articles NeurosciencesMachine learningAnimal behaviorBehavioral assessmentBiology
47. Context-dependent expression of a conditionally-inducible form of active Akt Park, Soyeon; Burke, Robert E.; Kareva, Tatyana; Kholodilov, Nikolai; Aime, Pascaline; Franke, Thomas F.; Levy, Oren Abraham; Greene, Lloyd A. 2018 Articles Protein kinasesDopaminergic neuronsNeurosciencesBiology
48. Functional odor classification through a medicinal chemistry approach Poivet, Erwan E.; Tahirova, Narmin Tahir; Peterlin, Zita; Xu, Lu; Zou, Dong-Jing; Acree, Terry; Firestein, Stuart J. 2018 Articles BiochemistryPharmaceutical chemistryOdorsBiology
49. Hydra Behavior Dataset Han, Shuting 2018 Data (Information) HydraAnimal behaviorAnimals--FoodBiology
50. Investigating The Role Of Signaling Pathways In Adult Stem Cells Governed By Population Asymmetry Melamed, David Eric 2018 Theses BiologyCellular signal transductionAdult stem cells
51. Light sheet theta microscopy for rapid high-resolution imaging of large biological samples Migliori, Bianca; Datta, Malika S.; Dupre, Christophe; Apak, Mehmet C.; Asano, Shoh; Gao, Ruixuan; Boyden, Edward S.; Hermanson, Ola; Yuste, Rafael; Tomer, Raju 2018 Articles BiologyMicroscopyBrain--ImagingHigh resolution imagingNeurosciences
52. Markers and Mechanisms of β-cell Dedifferentiation Fan, Jason Chen 2018 Theses MedicineBiologyCytologyPancreatic beta cells
53. Metabolic Strategies to Cope with Overcrowding in a Pseudomonas aeruginosa Biofilm Jo, Jeanyoung 2018 Theses BiologyMicrobiologyPseudomonas aeruginosaBiofilmsMicrobial respiration
54. Multi-level analysis of regulation of EGFR signalling during Drosophila melanogaster leg proximal-distal axis patterning Newcomb, Susan Elizabeth 2018 Theses BiologyGeneticsGrowth factors--ReceptorsEpidermal growth factorDrosophila melanogaster
55. On the Role of Sensory Cancellation and Corollary Discharge in Neural Coding and Behavior Enikolopov, Armen 2018 Theses NeurosciencesBiologySensory stimulationCochlear nucleus
56. Simultaneous two-photon imaging and two-photon optogenetics of cortical circuits in three dimensions Yang, Weijian; Carrillo-Reid, Luis; Bando, Yuki; Peterka, Darcy; Yuste, Rafael 2018 Articles BiologyOptogeneticsNeural circuitryImaging systems in biology
57. Spatially restricted regulation of cell competition by the cytokine Spaetzle Alpar, Elif Lale 2018 Theses BiologyGeneticsCytokinesCells--Growth--Regulation
58. Structural Studies of the Integrator Complex -- pre-UsnRNA 3'-end Processing Machinery Wu, Yixuan 2018 Theses BiologyBiochemistryCatalytic RNA
59. The Molecular Mechanism of Replication Independent Repair of DNA Interstrand Crosslinks Kato, Niyo 2018 Theses BiologyGeneticsDNA repairCrosslinking (Polymerization)Molecular biology
60. The Mre11-Rad50-Xrs2 Complex in the DNA Damage Response Oh, Julyun 2018 Theses BiologyGeneticsMolecular biologyDNA damageDNA repair
61. The Physical State of Water in Dormant Bacteria DeLay, Michael 2018 Theses BiophysicsBacteriaBacterial sporesWaterBiology
62. Understand Biology Using Single Cell RNA-Sequencing Ding, Hongxu 2018 Theses BiologyNucleotide sequenceSystems biology
63. An orphan cbb3-type cytochrome oxidase subunit supports Pseudomonas aeruginosa biofilm growth and virulence Jo, Jeanyoung; Cortez, Krista Lynn; Cornell, William-Cole; Price-Whelan, Alexa M.; Dietrich, Lars 2017 Articles BiofilmsPathogenic bacteriaPseudomonas aeruginosaCytochrome oxidaseBiology
64. Attenuation of Synaptic Potentials in Dendritic Spines Kwon, Taekyung; Sakamoto, Masayuki; Peterka, Darcy; Yuste, Rafael 2017 Articles DendritesBiophysicsNeuronsBiology
65. Bacterial tail anchors can target to the mitochondrial outer membrane Lutfullahoğlu-Bal, Güleycan; Keskin, Abdurrahman; Seferoğlu, Ayşe B.; Dunn, Cory D. 2017 Articles BiologyBacterial proteinsEndosymbiosisMitochondrial membranesEukaryotic cellsCell organelles--Formation
66. Cryo-electron microscopy and single particle reconstructions of the Leishmania major ribosome and of the encephalomyocarditis virus internal ribosome entry site bound to the 40S subunit Jobe, Amy Beth 2017 Theses Electron microscopyRibosomesLeishmaniaRNACryoelectronicsBiologyBiochemistryBiophysics
67. Overproduction of Neurons Is Correlated with Enhanced Cortical Ensembles and Increased Perceptual Discrimination Fang, Weiqun; Yuste, Rafael 2017 Articles NeuronsVisual perceptionVisual cortexDevelopmental neurobiologyBiology
68. Regulation of Proviral Expression and Post-Translational Modifications in Embryonic Cells Lee, Andreia H. 2017 Theses BiologyVirologyCytologyGenetic regulation
69. Reliable and Elastic Propagation of Cortical Seizures In Vivo Wenzel, Michael; Hamm, Jordan P.; Peterka, Darcy; Yuste, Rafael 2017 Articles SpasmsEpilepsyNeural circuitryBiologyPicrotoxin
70. Structural and Functional Studies of TRPML1 and TRPP2 Benvin, Nicole Marie 2017 Theses BiologyBiochemistryBiophysicsTRP channelsProteins--Structure
71. Study of Short Forms of P/Q-Type Voltage-Gated Calcium Channels Feng, Qiao 2017 Theses Central nervous systemNeurotransmittersBrain--DiseasesCalcium channelsBiology
72. The Development of an Inducible Akt as a Potential Gene Therapy for Parkinson’s Disease Park, Soyeon 2017 Theses BiologyNeurosciencesParkinson's diseaseGene therapyProtein kinases
73. The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3’-end processing Aik, Wei Shen; Lin, Min-Han; Tan, Dazhi; Tripathy, Ashutosh; Marzluff, William F.; Dominski, Zbigniew; Chou, Chi-Yuan; Tong, Liang 2017 Articles Crosslinking (Polymerization)DimersCrystals--StructureBiology
74. The population genetics of human disease: The case of recessive, lethal mutations Amorim, Carlos Eduardo G.; Gao, Ziyue; Baker, Zachary; Diesel, Jose Francisco; Simons, Yuval Benjamin; Haque, Imran S.; Pickrell, Joseph K.; Przeworski, Molly F. 2017 Articles Population geneticsBiologyMutation (Biology)Medical genetics
75. The roles of Threonine-4 and Tyrosine-1 of the RNA Polymerase II C-Terminal Domain: New insights into transcription from Saccharomyces cerevisiae Yurko, Nathan Michael 2017 Theses BiologyRNA polymerasesGenetic transcriptionSaccharomyces cerevisiae
76. Unraveling the link between the Mdm2-p53 axis and aging Wu, Danyi 2017 Theses BiologyMolecular biologyAgingp53 protein
77. Using Genomic Transgenes and the CRISPR/Cas9 Gene Editing System to Understand How Hedgehog Signaling Regulates Costal2 and Cubitus Interruptus in Drosophila melanogaster Little, Jamie 2017 Theses BiologyHedgehog proteinsMolecular biologyGenes
78. Watching the Replisome: Single-molecule Studies of Eukaryotic DNA Replication Duzdevich, Daniel 2017 Theses DNA replicationMolecular biologyCytologyEukaryotic cells--GeneticsBiologyBiophysics
79. A Genomic Map of the Effects of Linked Selection in Drosophila Elyashiv, Eyal; Sattath, Shmuel; Hu, Tina T.; Strutsovsky, Alon; McVicker, Graham; Andolfatto, Peter; Coop, Graham; Sella, Guy 2016 Articles Evolutionary geneticsBiodiversityNatural selection--Mathematical modelsGeneticsBiology
80. Connecting Cellular Redox State and Community Behavior in Pseudomonas aeruginosa PA14 Okegbe, Chinweike 2016 Theses MorphologyOxidation-reduction reactionBiofilmsBiology
81. Cryo-electron microscopy studies of dynamical features of ribosomes during the translation process Sun, Ming 2016 Theses BiophysicsProteins--StructureRibosomes--StructureRibosomesCryoelectronicsBiologyBiochemistry
82. Crystal Structure of the SPOC Domain of the Arabidopsis Flowering Regulator FPA Zhang, Yinglu; Rataj, Katarzyna; Simpson, Gordon G.; Tong, Liang 2016 Articles Crystals--StructureProteins--StructurePlants, Flowering of--Flowering timeBiology
83. Developing New Strategies for Engineering Novel Natural Product Metabolic Pathways Patenode, Caroline Anne 2016 Theses BiocatalysisNatural products--SynthesisBiologyMicrobiologyChemistry
84. Human Germline Mutation and the Erratic Evolutionary Clock Moorjani, Priya Gian; Gao, Ziyue; Przeworski, Molly F. 2016 Articles Mutation (Biology)Evolution (Biology)Germ cellsBiology
85. Interpreting the Dependence of Mutation Rates on Age and Time Gao, Ziyue; Wyman, Minyoung J.; Sella, Guy; Przeworski, Molly F. 2016 Articles DNA replicationCell divisionCells--Growth--Mathematical modelsDNA repairMutation (Biology)GeneticsBiologyCytology
86. Learning cell states from high-dimensional single-cell data Levine, Jacob Harrison 2016 Theses BioinformaticsCells--MeasurementMyeloid leukemiaCells--Computer programsBiologyOncology
87. Physiology of Pseudomonas Aeruginosa Phenazine Production and Transport Sakhtah, Hassan 2016 Theses PhenazineMetabolitesBiofilmsPseudomonas aeruginosaBiology
88. The Multilayer Connectome of Caenorhabditis elegans Bentley, Barry; Branicky, Robyn; Barnes, Christopher L.; Chew, Yee Lian; Yemini, Eviatar; Bullmore, Edward T.; Vértes, Petra E.; Schafer, William R. 2016 Articles NeuronsNeural networks (Neurobiology)Caenorhabditis elegansNeuropeptidesSynapsesBrain mappingNeurosciencesBiology
89. Cryo-EM and time-resolved cryo-EM studies on translation Chen, Bo 2015 Theses RibosomesProteins--SynthesisGenetic translationElectron microscopyBiophysicsBiology
90. Deciphering End Resection in Double-Strand Break repair in Saccharomyces cerevisiae Chen, Huan 2015 Theses Saccharomyces cerevisiaeDNA repairDNA damageBiologyMolecular biologyGenetics
91. Identification and Biophysical Characterization of Small Molecules Modulating Protein Disulfide Isomerase in Neurodegenerative Diseases Kaplan, Anna 2015 Theses Nervous system--DegenerationNeuroprotective agentsProtein disulfide isomeraseBiophysicsBiochemistryBiology
92. Regulatory Logic of Pan-neuronal Gene Expression in Caenorhabditis elegans Stefanakis, Nikolaos 2015 Theses BiologyGenetics
93. Structural Studies of the Fungal pre-mRNA 3'-end Processing Machinery Jurado, Ashley Rae 2015 Theses ProteinsRNA splicingScission (Chemistry)Messenger RNAMolecular biologyBiologyBiochemistry
94. The Regulation of PREX2 by Phosphorylation Barrows, Douglas Walker 2015 Theses PhosphorylationInsulin--Mechanism of actionPhosphoinositidesBiologyBiochemistryPharmacology
95. An Aerobic Exercise: Defining the Roles of Pseudomonas aeruginosa Terminal Oxidases Jo, Jeanyoung; Price-Whelan, Alexa; Dietrich, Lars 2014 Articles BiochemistryBiologyMicrobiology
96. Broadening horizons: holistic viewpoints from the Biology of Genomes Carr, Ambrose James; Pe'er, Dana 2014 Articles Medical transcriptionMutation (Biology)GenomicsBiologyBiomechanics
97. Elucidating the roles of PARP1 and RBBP6 in the regulation of pre-mRNA 3' end processing Campigli Di Giammartino, Dafne 2014 Theses Biology
98. Gene regulatory factors that control the identities of specific neuron types in Caenorhabditis elegans Zhang, Feifan 2014 Theses GeneticsBiology
99. Heterogeneity and Context-Specificity in Biological Systems Litvin, Oren 2014 Theses BiologyBioinformaticsGenetics—ResearchBacterial diversity--Genetic aspectsGenetics--Mathematical models
100. Mid-channel proteolysis of the L-type voltage gated calcium channel and the potential role of amyloid-β precursor protein Henckels, Kathryn 2014 Theses BiologyNeurosciences