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1. A p53-independent role for MDM2-MDMX in cell cycle progression

Klein, Alyssa Michelle
2021
Theses
CytologyMolecular biologyBiochemistryCancerMutation

2. Structure and Function of a Transposon-Encoded CRISPR-Cas System

Halpin-Healy, Tyler Sheehan
2021
Theses
BiochemistryBiophysicsMolecular biologyVibrio choleraeRNADNA

3. Atf5 Links Olfactory Receptor Induced Stress Response to Proper Neuronal Function

Kahiapo, Jerome Keoki
2020
Theses
CytologyBiochemistryMolecular biologyOlfactory receptor genesSmellSensory neuronsMammals

4. Liver X Receptor cis-Repression and Cholesterol Efflux Restrain Innate Immunity and Coronary Artery Disease

Thomas, David George
2019
Theses
CytologyMolecular biologyBiochemistryAtherosclerosis--PreventionImmunityNuclear receptors (Biochemistry)

5. Mechanisms and therapeutic targeting of NT5C2 mutations in relapsed acute lymphoblastic leukemia

Dieck, Chelsea
2019
Theses
BiochemistryLymphoblastic leukemiaDrug resistanceOncologyMutation (Biology)Molecular biology

6. Molecular Approaches to Targeting Oncogenic KRAS and Ferroptosis

Feng, Huizhong
2019
Theses
Molecular biologyBiochemistryCytologyBiochemical markersCancerCell death

7. Structural Analyses of the Transient Receptor Potential Channels TRPV3 and TRPV6

McGoldrick, Luke Lawrence Reedy
2019
Theses
BiochemistryMolecular biologyTRP channelsStructure-activity relationships (Biochemistry)Ion channels

8. Structural studies of the yeast transcription termination complex Nrd1-Nab3-Sen1

Zhang, Yinglu
2019
Theses
BiologyMolecular biologyBiochemistryRNA polymerasesGenetic transcription

9. The Mechanism of NusG-Mediated Transcription-Translation Coupling and The Role of RacR in Transcription Regulation in Escherichia coli

Bailey, Elizabeth Jean
2019
Theses
BiochemistryMolecular biologyChemistryGenetic transcription--RegulationEscherichia coli

10. Shared Molecular Features of Inherited and Sporadic ALS/FTD

Conlon, Erin Grace
2018
Theses
BiochemistryGeneticsNeurosciencesAmyotrophic lateral sclerosisFrontotemporal dementiaMolecular biology

11. The BARD1 BRCT Domain in Tumor Suppression and Genome Stability

Billing, David
2018
Theses
Molecular biologyCytologyBiochemistryTumor suppressor proteinsGenomes

12. RPGRIP1L and FTO – genes implicated in the effects of FTO intronic sequence variants on food intake – also affect adipogenesis and adipocyte biology.

Martin-Carli, Jayne Frances
2017
Theses
BiochemistryCytologyMolecular biologyObesity--Genetic aspects

13. Single-molecule observations of hRPA, RAD51, and RAD52 on single-stranded DNA

Ma, Chu Jian
2017
Theses
BiochemistryBiophysicsDNA replicationGenetic recombinationMolecular biology

14. Chloride Intracellular Channels 1 and 4 function in distinct branches of S1P signaling to regulate endothelial cell behavior and vascular development

Jilishitz, Irina
2016
Theses
MorphogenesisGrowth factorsNeovascularizationEndothelial cellsMolecular biologyBiochemistry

15. Investigating the role of the RNA binding protein TDP-43 in Amyotrophic Lateral Sclerosis using animal and cell-based models of disease

Lehrer, Helaina
2015
Theses
Molecular biologyNeurosciencesBiochemistry

16. Reprogramming protein synthesis for cell engineering

Anzalone, Andrew Vito
2015
Theses
Proteins--SynthesisBioengineeringAmino acids--BiotechnologyRNA-protein interactionsSynthetic biologyBiochemistryChemistry, OrganicBiologyMolecular biology

17. Structural Studies of the Fungal pre-mRNA 3'-end Processing Machinery

Jurado, Ashley Rae
2015
Theses
ProteinsRNA splicingScission (Chemistry)Messenger RNAMolecular biologyBiologyBiochemistry

18. Molecular Basis for the Recognition of the Regulatory Stem-loop Structures in Eukaryotic Messenger RNAs

Tan, Dazhi
2014
Theses
Messenger RNARNA-protein interactionsEukaryotic cellsBiologyBiochemistryMolecular biology

19. Building a Genetic System in Yeast to Search for High Affinity Proteins in Sequence Space

Merguerian, Matthew Douglas
2013
Theses
Molecular biologyBiochemistryCytology

20. Structural and Biochemical Characterizations of the Symplekin-Ssu72-CTD Complex in Pre-mRNA 3' end Processing

Xiang, Kehui
2013
Theses
BiochemistryGenetic transcriptionRNA polymerasesBiologyMolecular biology

21. Regulation of alternative splicing and its connections to cancer

Chen, Mo
2011
Theses
BiologyMolecular biologyBiochemistry

22. Studies on mammalian pre-mRNA splicing : connections to transcription and cancer

David, Charles J.
2011
Theses
BiochemistryMolecular biology