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1. A genetically-encoded biosensor and a conditional gene expression system for investigating Notch activity in vivo

Shaffer, Justin Matthew
2022
Theses
Developmental biologyGeneticsGene expressionCell interactionCaenorhabditis elegans--GeneticsExons (Genetics)

2. Autophagy and Hematopoietic Stem Cell Potential During Aging

Dellorusso, Paul Vincent
2022
Theses
BiologyGeneticsImmunologyAutophagic vacuolesHematopoietic stem cells--Therapeutic useCells--AgingGlucose--Metabolism

3. Mre11-Rad50-Xrs2 Complex in Coordinated Repair of DNA Double-Strand Break Ends from I-SceI, TALEN, and CRISPR-Cas9

Lee, So Jung
2022
Theses
GeneticsDNA damageGenomesHaploidyDNA repairGene editing

4. The contribution of 14-3-3 proteins to protein aggregate homeostasis

Herod, Sarah Grace
2022
Theses
GeneticsBiologyAmyloidAlzheimer's disease--EtiologyParkinson's diseaseNervous system--DegenerationMeiosisRNA-protein interactions

5. A Precision Medicine Approach to Understanding KIF1A Associated Neurological Disorder

Boyle, Lia
2021
Theses
GeneticsNeurosciencesMedicineNervous system--Diseases--EtiologyNervous system--Diseases--Genetic aspectsNervous system--Diseases--TreatmentNervous system--DegenerationAxonsDendrites

6. Beyond summary statistics: extracting etiological insights from genome-wide association cohorts

Yuan, Jie
2021
Theses
Computer scienceGeneticsStatisticsSchizophreniaHuman genome--ResearchSchizophrenia--Etiology

7. Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements

Murphy, David
2021
Theses
GeneticsEvolution (Biology)BiologyHuman genomeBiodiversity

8. Disentangling mutation and selection in human genetic variation: promises and pitfalls

Agarwal, Ipsita
2021
Theses
BiologyGeneticsEvolution (Biology)Mutation (Biology)Human genomeExomes

9. Engineering Patient-specific Liver Microtissues with Prolonged Phenotypic Maintenance and Disease Modeling Potential

Huang, Dantong
2021
Theses
Biomedical engineeringCytologyGeneticsLiver--DiseasesFatty liverPhenotype

10. Genome stability in the preimplantation embryo

Zuccaro, Michael V.
2021
Theses
CytologyGeneticsPhysiologyZygotesEmbryologyMammals--DevelopmentDNA damageHaploidyEmbryonic stem cells--Research

11. Investigations into a bHLH code for Caenorhabditis elegans somatic gonad regulatory cell fate and function

Littleford, Hana Elisabeth
2021
Theses
Developmental biologyGeneticsCaenorhabditis elegans--GeneticsGenetic regulation

12. Mechanisms Underlying Phenotypic Heterogeneity in Simplex Autism Spectrum Disorders

Chiang, Andrew Hann
2021
Theses
GeneticsBiologyBioinformaticsAutism spectrum disorders--Genetic aspectsPhenotypeMutagenesis

13. Microproteins and Epigenetic Remodeling in Cancer and Aging

Quinn, Stuart Aidan
2021
Theses
GeneticsLeukemiaAgingCancer--Gene therapyPolypeptidesAmino acidsHematopoietic stem cellsEpigenetics

14. Natural selection and demography shape the genomes of New World birds

Rocha Moreira, Lucas
2021
Theses
Evolution (Biology)GeneticsEcologyGenomesBirdsHairy woodpeckerDowny woodpecker

15. Neuronal specification by homeodomain transcription factors in Caenorhabditis elegans

Reilly, Molly Booth
2021
Theses
NeurosciencesDevelopmental biologyGeneticsCaenorhabditis elegansNervous systemNeuronsHomeobox genes

16. Post-transcriptional gene expression regulation in developmental disorders

Kitaygorodsky, Alexander
2021
Theses
BioinformaticsGeneticsComputer scienceGene expressionGenomesNeural networks (Neurobiology)

17. Reading the Disease Leaves: Signals, signatures and synchrony in neurodevelopmental disorders

Ressler, Andrew
2021
Theses
NeurosciencesGeneticsNervous system--Diseases--Genetic aspectsNeurodevelopmental treatmentTherapeuticsPhenotypeDiseases--Animal modelsToxicity testing--In vitro

18. Spatial regulation of protein function in cell division and midbody assembly

Hirsch, Sophia Madeleine
2021
Theses
CytologyGeneticsCytokinesisCell divisionSpindle (Cell division)Caenorhabditis elegans--GeneticsNematodes--Genetics

19. The spatial distribution of cortical interneurons: the role of clustered protocadherins

Gallerani, Nicholas Edmund
2021
Theses
NeurosciencesDevelopmental biologyCerebral cortexInterneuronsMiceGenetics

20. Utilizing cell-specific chromatin accessibility states to understand appendage patterning and diversification in Drosophila Melanogaster

Loker, Ryan Edmund
2021
Theses
Developmental biologyGeneticsBiologyDrosophila melanogaster--Genetics

21. Characterizing human regulatory genetic variation using CRISPR/Cas9 genome editing

Brandt, Margot
2020
Theses
GeneticsHuman genetics--VariationCRISPR (Genetics)Medical geneticsGene editing

22. Circuit transcription factors in Caenorhabditis elegans

Berghoff, Emily Greta
2020
Theses
NeurosciencesGeneticsNeuronsNervous systemGene expression--ResearchCaenorhabditis elegans--GeneticsNeurotransmitters

23. Electronic Health Record-Derived Phenotyping Models to Improve Genomic Research in Stroke

Thangaraj, Phyllis Mary
2020
Theses
BioinformaticsGeneticsCerebrovascular diseaseCerebrovascular disease--Risk factorsMedical records--Data processingMachine learning--Industrial applications

24. Elucidating the abilities of MDM2, MDMX and p21 to regulate ferroptosis

Venkatesh, Divya
2020
Theses
BiologyGeneticsLipids--PeroxidationCell deathCancer

25. Evaluation of a precision medicine approach for hnRNP U-related developmental epileptic encephalopathy using a mouse model of disease

Dugger, Sarah Anne
2020
Theses
GeneticsNeurosciencesBiologyGenetic transcription--RegulationNervous system--Diseases

26. Genetic Analysis of the "Levin Rat" - a Rodent Model of Diet-Sensitive Obesity

Goffer, Yossef
2020
Theses
GeneticsNeurosciencesObesityObesity--Genetic aspects

27. Investigations into roles for endocytosis in LIN-12/Notch signaling and its regulation

Chan, Jessica Yu
2020
Theses
GeneticsEndocytosisLigands (Biochemistry)Caenorhabditis elegansVulvaCellular signal transduction

28. Leveraging DNA Damage Response Pathways to Enhance the Precision of CRISPR-Mediated Genome Editing

Nambiar, Tarun S.
2020
Theses
GeneticsMolecular biologyGene editingGenomesDNA

29. Mosaicism and the genetic architecture of congenital heart disease

Hsieh, Alexander Lin
2020
Theses
BioinformaticsGeneticsCongenital heart diseaseMosaicismDiseases--Causes and theories of causation

30. Proximal-distal patterning of the lung: molecular determinants in lung development and evolution

van Soldt, Benjamin Jonathan
2020
Theses
Developmental biologyGeneticsMolecular biologyLungsPulmonary alveoliMammals--Development

31. Screening Whole-Genome Sequenced Strains to Investigate Genetic Determinants of Gentle Touch Sensitivity in Caenorhabditis elegans

Lawry, Stephanie Terese
2020
Theses
GeneticsBiologyGenomicsGenomesNematodesTouchNeurosciences

32. The FYN-TRAF3IP2 gene fusion drives oncogenic NF-κB signaling in peripheral T cell lymphoma

Kim, Christine Sheila
2020
Theses
Molecular biologyGeneticsOncologyHTLV (Viruses)CarcinogenesisGene fusion

33. The role of circadian-regulated genes in Drosophila behavior

Pantalia, Meghan
2020
Theses
NeurosciencesGeneticsCircadian rhythmsNeuronsNeurotransmittersDrosophila--Genetics

34. The role of SMARCAD1 during replication stress

Joseph, Sarah
2020
Theses
Molecular biologyGeneticsBreast--Cancer--Genetic aspectsOvaries--Cancer--Genetic aspectsHeterozygosity

35. Utilizing functional genomics approaches to characterize risk genes in alopecia areata

Erjavec, Stephanie O'Toole
2020
Theses
GeneticsImmunologyAlopecia areataHair--Diseases--Genetic aspectsGenomicsAutoimmune diseases

36. Yeast adaptation and survival under acute exposure to lethal ethanol stress

Yang, Jamie Siyu
2020
Theses
BiologyGeneticsStress (Physiology)Adaptation (Biology)Yeast

37. Axon-axon and axon-target interactions underlying somatosensory circuit assembly in Drosophila

Galindo, Samantha Emily
2019
Theses
NeurosciencesDevelopmental biologyGeneticsDrosophilaAxons

38. Cell fate restriction in Caenorhabditis elegans

Rahe, Dylan Parker
2019
Theses
GeneticsCaenorhabditis elegansCell determinationCytology

39. Gene Regulatory Compatibility in Bacteria: Consequences for Synthetic Biology and Evolution

Johns, Nathan Isaac
2019
Theses
MicrobiologyGeneticsGenetic regulationGenetic engineeringSynthetic biology

40. Genetic Mechanisms of Regulated Stochastic Gene Expression

Horta, Adan
2019
Theses
NeurosciencesBiochemistryGeneticsOlfactory receptor genesGene expressionCadherinsHuman genetics--Variation

41. Interstitial Telomere Sequences Disrupt Break Induced Replication

Stivison, Elizabeth Anne
2019
Theses
GeneticsMolecular biologyTelomereDNA damageDNA replication

42. Investigating the utility of exome sequencing for kidney disease

Groopman, Emily
2019
Theses
GeneticsBioinformaticsMedicineKidneys--DiseasesExomes

43. Long noncoding RNAs are critical regulators of pancreatic islet development and function

Singer, Ruth Arielah
2019
Theses
GeneticsEndocrinologyNon-coding RNAIslands of Langerhans

44. Notch signaling facilitates in vitro generation of cross-presenting classical dendritic cells

Kirkling, Margaret Elizabeth
2019
Theses
ImmunologyDendritic cellsCell interactionGenetics

45. Novel functions of C9ORF72, a gene involved in ALS/FTD

Fomin, Vitalay
2019
Theses
BiologyBiochemistryGeneticsCytologyAmyotrophic lateral sclerosisFrontotemporal dementiaGene expression

46. Nuclear Arp2/3 drives DNA double-strand break clustering for homology-directed repair

Schrank, Benjamin Robin
2019
Theses
GeneticsOncologyBiologyDNA damageDNA repairCytoskeletal proteins

47. Population Genetics of Mutation Load and Quantitative Traits in Humans

Simons, Yuval Benjamin
2019
Theses
GeneticsBiologyHuman population geneticsMutation (Biology)

48. Progressive restriction of CNS cell-fate potential by the transiently expressed transcription factor Nkx2.2

Abarinov, Elena
2019
Theses
GeneticsNeurosciencesTranscription factorsRepressors, GeneticCentral nervous system

49. Quantitative trait variation and adaptation in contemporary humans

Mostafavi, Hakhamanesh
2019
Theses
BiologyGeneticsHuman evolutionGenomes--Data processingHuman genetics--VariationMortality

50. Statistical Methods for Genetic Studies with Family History of Diseases

Lee, Annie Jehe
2019
Theses
BiometryStatisticsGeneticsFamilial diseasesEpidemiology

51. Systems Genetics of DNA Damage Tolerance – Cisplatin, RAD5 & CRISPR-mediated Nonsense

Bryant, Eric Edward
2019
Theses
GeneticsBioinformaticsBiology--ClassificationDNA damageCisplatinCRISPR (Genetics)

52. Genomic and machine-learning analysis of germline variants in cancer

Madubata, Chioma
2018
Theses
BioinformaticsCytologyGeneticsMachine learningGerm cellsCancer

53. Multi-level analysis of regulation of EGFR signalling during Drosophila melanogaster leg proximal-distal axis patterning

Newcomb, Susan Elizabeth
2018
Theses
BiologyGeneticsGrowth factors--ReceptorsEpidermal growth factorDrosophila melanogaster

54. Quantitative Approaches to the Genomics of Clonal Evolution

Zairis, Sakellarios
2018
Theses
GeneticsBioinformaticsMathematicsGenomicsClones (Plants)Evolution (Biology)

55. Redox-Balancing Strategies in Pseudomonas aeruginosa

Lin, Yu-Cheng
2018
Theses
MicrobiologyGeneticsPseudomonas aeruginosaBiofilmsOxidation-reduction reaction

56. Shared Molecular Features of Inherited and Sporadic ALS/FTD

Conlon, Erin Grace
2018
Theses
BiochemistryGeneticsNeurosciencesAmyotrophic lateral sclerosisFrontotemporal dementiaMolecular biology

57. Spatially restricted regulation of cell competition by the cytokine Spaetzle

Alpar, Elif Lale
2018
Theses
BiologyGeneticsCytokinesCells--Growth--Regulation

58. The Function and Regulation of Sleep in Drosophila melanogaster

Hill, Vanessa Maria
2018
Theses
BiologyGeneticsNeurosciencesDrosophila melanogasterSleep

59. The Molecular Mechanism of Replication Independent Repair of DNA Interstrand Crosslinks

Kato, Niyo
2018
Theses
BiologyGeneticsDNA repairCrosslinking (Polymerization)Molecular biology

60. The Mre11-Rad50-Xrs2 Complex in the DNA Damage Response

Oh, Julyun
2018
Theses
BiologyGeneticsMolecular biologyDNA damageDNA repair

61. Therapy and mechanism of Mendelian eye diseases

Tsai, Yi-Ting
2018
Theses
GeneticsBiomedical engineeringRetinal degenerationEye--Diseases--TreatmentTherapeutics

62. The Role of Eukaryotic Recombinase Loop L1 During Homologous Recombination

Steinfeld, Justin Benjamin
2018
Theses
BiophysicsBiochemistryGeneticsGenetic recombinationEukaryotic cells

63. The Saccharomyces cerevisiae Srs2 Helicase Regulates Homologous Recombination through the Disassembly of Recombination Intermediates

Kaniecki, Kyle Stephen
2018
Theses
GeneticsBiophysicsBiochemistrySaccharomyces cerevisiaeGenetic recombination

64. Accurate and Sensitive Quantification of Protein-DNA Binding Affinity

Rastogi, Chaitanya
2017
Theses
GeneticsBiophysicsStatisticsDNA-protein interactionsTranscription factors

65. Biology of maintenance and de novo methylation mediated by DNA methyltransferase-1

Yarychkivska, Olga
2017
Theses
DNA--MethylationMethyltransferasesDNA replicationCell divisionGenomicsGeneticsBiochemistryBiology

66. Historical and Contemporary Genetic Perspectives on New World Monk Seals (Genus Neomonachus)

Mihnovets, Alicia Nicole
2017
Theses
Monk sealsEvolution (Biology)PhylogenyExtinction (Biology)EcologyWildlife conservationGenetics

67. Investigating the Role of ILDR2 in Hepatic Lipid Metabolism and Pancreas Islet Function

Millings, Elizabeth Joy
2017
Theses
BiologyGeneticsNutritionMetabolic syndromeIslands of Langerhans

68. Making Memories: Modes and Mechanisms of Gene Silencing by the Polycomb Repressive Complexes in Drosophila

Coleman, Rory Tristan
2017
Theses
MetazoaPlants--DevelopmentDrosophilaDrosophila--GeneticsDrosophila--DevelopmentGene expressionGeneticsMolecular biology

69. Mechanisms of sexually dimorphic development in the nervous system of Caenorhabditis elegans

Weinberg, Peter J.
2017
Theses
Caenorhabditis elegansDimorphism (Animals)NeurophysiologySexual dimorphism (Animals)Nervous systemReproductionNeurosciencesGenetics

70. The Homologous Recombination Machinery Regulates Increased Chromosomal Mobility After DNA Damage in Saccharomyces cerevisiae

Smith, Michael Joseph
2017
Theses
GeneticsSaccharomyces cerevisiaeDNA damageDNA repairChromosomes

71. The Role of Osteocalcin in the Regulation of Brain Development and Functions

Khrimian, Lori N.
2017
Theses
Brain--GrowthCentral nervous system--GrowthCognitionCognitive neuroscienceCentral nervous systemGenetics

72. Transcriptional control of tumor suppressor genes in cancer

Pappas, Kyrie Jean
2017
Theses
AntioncogenesCancer--Genetic aspectsTumor suppressor proteinsOncologyGenetic transcription--RegulationCancerBiologyGenetics

73. 3-Phosphoinositide-dependent kinase-1 (PDK1)-mediated signaling regulates hematopoietic stem cell (HSC) quiesence by governing the oxidative response

Matsushima, Danielle Erina
2016
Theses
Hematopoietic stem cellsBlood--DiseasesHematopoiesis--RegulationGeneticsImmunology

74. Behavior and Immunity in Drosophila melanogaster

Allen, Victoria Wing
2016
Theses
Circadian rhythmsAnimal behaviorDrosophila melanogaster--PhysiologyImmunityGeneticsBiology

75. Cell fate restriction in Caenorhabditis elegans is orchestrated by precise chromatin organization and transcription factor activity

Patel, Tulsi
2016
Theses
CellsCaenorhabditis elegansCells--Mechanical propertiesChromatinPlasticityGenetics

76. Confounding effects in gene expression and their impact on downstream analysis

Lachmann, Alexander
2016
Theses
Genetic regulationGenetic regulation--Data processingGene expressionGene expression--Data processingBioinformaticsGene regulatory networksGenetics

77. Design and synthesis of novel nucleotide analogs and protein conjugates for DNA sequencing

Guo, Wenjing
2016
Theses
Proteins--SynthesisNucleotide sequenceChemical engineeringChemistryGenetics

78. Diversification of Caenorhabditis elegans motor neuron identity via selective effector gene repression

Kerk, Sze Yen
2016
Theses
Cholinergic mechanismsCaenorhabditis elegansRepressors, GeneticNeuronsNeurosciencesGenetics

79. Genetic Epidemiological Characterization of Two Major Obesity Candidate Genes: The 16p11.2 BP4-BP5 Microdeletion and the Fat-Mass and Obesity-Associated (FTO) Locus

Gill, Richard
2016
Theses
Obesity--EpidemiologyObesityHomeostasisObesity--Genetic aspectsEpidemiologyGenetics

80. Genetics of ABCA4-associated Diseases and Retinitis Pigmentosa

Xie, Yajing
2016
Theses
Retinitis pigmentosaRetinitis pigmentosa--Genetic aspectsMedical geneticsRetinal degenerationGeneticsBioinformatics

81. Novel negative regulation of LIN-12/Notch in Caenorhabditis elegans

Deng, Yuting
2016
Theses
Caenorhabditis elegans--GeneticsGeneticsCaenorhabditis elegans

82. Population Genetic Structure and Reproductive Ecology of Crocodylus across Local and Regional scales

Rossi, Natalia Alejandra
2016
Theses
Animal population geneticsSexual behavior in animalsCrocodilesEcologyGenetics

83. Regulation of Runx2 Accumulation and Its Consequences

Shimazu, Junko
2016
Theses
Osteoblasts--MetabolismGlucose--MetabolismBones--MetabolismGenetics

84. Spatiotemporal and Mechanistic Analysis of Nkx2.2 Function in the Pancreatic Islet

Churchill, Angela Josephine
2016
Theses
Cell differentiationPancreatic beta cellsIslands of LangerhansEndocrinologyGenetics

85. The role of intestinal mononuclear phagocytes in control of mucosal T cell homeostasis

Panea, Casandra M.
2016
Theses
Intestines--MicrobiologyT cellsMacrophagesImmunologyGeneticsMicrobiology

86. Analysis of Ureteric Bud Morphogenesis by Reassociation of Fetal Kidney Cells

Leclerc, Kevin
2015
Theses
KidneysMetalloproteinasesExtracellular matrixMorphogenesis--Molecular aspectsGeneticsMolecular biology

87. A New Estimating Equation Based Approach for Secondary Trait Analyses in Genetic Case-control Studies

Song, Xiaoyu
2015
Theses
BiometryGeneticsCase-control methodGeneralized estimating equations

88. Biology and the Philosophy of History in Mid-Twentieth-Century France

Gabel, Isabel
2015
Theses
HistoryScience and civilizationGeneticsEvolution (Biology)Philosophy

89. Deciphering End Resection in Double-Strand Break repair in Saccharomyces cerevisiae

Chen, Huan
2015
Theses
Saccharomyces cerevisiaeDNA repairDNA damageBiologyMolecular biologyGenetics

90. Deciphering the Role of p24 Proteins in COPII-mediated Protein Secretion

D'Arcangelo, Jennifer G.
2015
Theses
Endoplasmic reticulumMolecular geneticsProteins--SecretionCytologyMolecular biologyGenetics

91. Function and regulation of the transcription factor HLH-2/E2A during gonadogenesis in Caenorhabditis elegans.

Sallee, Maria Danielle
2015
Theses
Genetics

92. Genetic Basis of Neuronal Subtype Differentiation in Caenorhabditis elegans

Zheng, Chaogu
2015
Theses
Caenorhabditis elegans--GeneticsNeuronsDevelopmental neurobiologyNeurosciencesGenetics

93. Genetic Mechanisms Controlling Human Hair Growth

DeStefano, Gina Marie
2015
Theses
Genetics

94. Identifying genes required for the formation of neurons from skin cells using forward genetic screens and whole genome sequencing in C. elegans

Minevich, Gregory
2015
Theses
Neurons--GrowthNeural stem cellsDevelopmental neurobiologyGene mappingGeneticsNeurosciencesBioinformatics

95. New Perspectives on Gata Redundancy in Mouse Embryogenesis

Borok, Matthew Jay
2015
Theses
Transcription factorsPancreasEmbryologyGenetics

96. Regulation of E Protein Activity During Dendritic Cell Development

Grajkowska, Lucja Teresa
2015
Theses
Proteins--Synthesis--RegulationMolecular immunologyDendritic cellsImmunologyGenetics

97. Regulatory Logic of Pan-neuronal Gene Expression in Caenorhabditis elegans

Stefanakis, Nikolaos
2015
Theses
BiologyGenetics

98. Replication Protein A in the Maintenance of Genome Stability

Deng, Sarah
2015
Theses
DNA repairGenomesDNA-binding proteinsGeneticsBiologyMicrobiology

99. The Roles of F-box and Leucine-Rich Repeat Protein 4 (FBXL4) in Mitochondrial Encephalopathy and T-cell Acute Lymphoblastic Leukemia

Haydu, Julie Erika M.
2015
Theses
Mitochondrial pathologyGeneticsMolecular biologyMedicine

100. Aberrantly Expressed CeRNAs Account for Missing Genomic Variability of Cancer Genes via MicroRNA-Mediated Interactions

Chiu, Hua-Sheng
2014
Theses
CarcinogenesisOncogenesBioinformaticsRNABiology--ClassificationGenetics