1. Altered lipid metabolism in persister cells drives ferroptosis sensitivity Reznik, Eduard 2024 Theses CytologyBiochemistryCell deathCancer cells--Effect of drugs onCancer--ChemotherapyBiochemical markers
2. Mammalian translation termination intermediates captured using PDMS microfluidics-based time-resolved cryo-EM (TRCEM) Dadhwal, Prikshat 2024 Theses BiologyBiochemistryBiophysicsEukaryotic cells--GeneticsGenetic translationRibosomesSilicaCryoelectronics
3. Non-canonical WDR33 Isoforms: Characterization, Regulation, and Functional Significances in STING-Mediated Innate Immune Responses Liu, Lizhi 2023 Theses Molecular biologyImmunologyBiochemistryAmino acid sequenceGene expressionMessenger RNAOligomerizationInterferon
4. Small molecules modulating ferroptosis in disease models Tan, Hui 2023 Theses BiochemistryCell deathCancer--TreatmentDiseases--EtiologyHuntington's diseaseLymphomasKidneys--DiseasesNervous system--Diseases
5. Structural and Functional Studies of CNG channels Hu, Zhengshan 2023 Theses BiologyBiochemistryBiophysicsCyclic nucleotides--AnalysisIon channelsCryoelectronicsElectron microscopy
6. Structure and Function of Glutamate Receptor-Like Channels (GLRs) Green, Marriah Noel 2023 Theses NutritionBiochemistryBiophysicsGlutamic acidLigand binding (Biochemistry)Arabidopsis thalianaCell receptors
7. Structure and Neutralization of Viral Fusion Proteins Casner, Ryan Gavin 2023 Theses BiochemistryCOVID-19 (Disease)ImmunoglobulinsCryoelectronicsVaccines--Design
8. Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposases King, Rebeca Teresa 2023 Theses GeneticsBiochemistryPersonalized medicineCRISPR (Genetics)DNA-binding proteinsNucleasesDouble-stranded RNA
9. The role of ER-mitochondria contact sites in the regulation of glucose metabolism: a tale of two mitochondria and its relevance to amyotrophic lateral sclerosis Tamucci, Kirstin Arianna 2023 Theses BiochemistryMolecular biologyNutritionGlucose--MetabolismMitochondriaMitochondrial membranesEndoplasmic reticulumMotor neuronsAmyotrophic lateral sclerosis
10. Lipids on Fire: Identifying and Targeting Subcellular Membranes that Drive Ferroptosis Von Krusenstiern, Alfred Nikolai 2022 Theses BiochemistryCell deathLipids--PeroxidationCancer--TreatmentEndoplasmic reticulumFatty acidsRaman effectConfocal fluorescence microscopy
11. Molecular Insights into Ferroptosis as a Therapeutic Target for Huntington’s Disease Daniels, Jacob D. 2022 Theses PharmacologyBiochemistryHuntington's disease--TreatmentCell deathProbucol
12. Structural studies on bestrophin anion channels by cryogenic electron microscopy Owji, Aaron Paul 2022 Theses BiophysicsBiochemistryEye--PhysiologyChloride channelsKlebsiella pneumoniaeMammalsMutagenesis
13. The Role of Chromatin in Olfaction Kodra, Albana Lavinia 2022 Theses ChromatinOlfactory receptor genesCOVID-19 (Disease)--Psychological aspectsGeneticsMolecular biologyBiochemistryEpithelium
14. A p53-independent role for MDM2-MDMX in cell cycle progression Klein, Alyssa Michelle 2021 Theses CytologyMolecular biologyBiochemistryCancerMutation
15. Directed Evolution of Protein Receptor Binding for Small Molecule Therapeutics Using Fluorescence Polarization Bannier, Sean David 2021 Theses ChemistryBiochemistryBiophysicsTetracylcinesProtein bindingPolarization (Light)Yeast
16. Discovery of Novel Ferroptosis Regulators Using Genetic and Lipidomic Analyses Bezjian, Carla Tara 2021 Theses CytologyMolecular biologyBiochemistryCell deathGenetic regulationPhospholipids
17. How to steal ribosomes: structural studies of two different internal ribosome entry sites Neupane, Ritam 2021 Theses BiochemistryBiophysicsVirologyRibosomesEukaryotic cells
18. Novel Functions for Dynein Adaptor RILP in Neuronal Autophagy Khobrekar, Noopur V. 2021 Theses BiologyNeurobiologyBiochemistryDyneinAutophagic vacuolesCell organelles
19. Structural and Biochemical Studies of the Human pre-mRNA 3’-end Processing Complex Hamilton, Keith 2021 Theses BiochemistryBiophysicsMessenger RNA--AnalysisMutagenesis
20. Structural and functional characterization of the retinol-binding protein receptor STRA6 Costabile, Brianna Kay 2021 Theses BiochemistryEpitheliumVitamin A deficiencyVitamin APlacentaChoroid plexusElectron microscopyCalmodulin--Physiological effectZebra danio
21. Structure and Function of a Transposon-Encoded CRISPR-Cas System Halpin-Healy, Tyler Sheehan 2021 Theses BiochemistryBiophysicsMolecular biologyVibrio choleraeRNADNA
22. Visualizing cell surface interactions using cryogenic electron microscopy Rapp, Micah 2021 Theses BiophysicsBiochemistryElectron microscopyCOVID-19 (Disease)Low temperature engineeringCell membranesCell receptorsImmunoglobulins
23. Atf5 Links Olfactory Receptor Induced Stress Response to Proper Neuronal Function Kahiapo, Jerome Keoki 2020 Theses CytologyBiochemistryMolecular biologyOlfactory receptor genesSmellSensory neuronsMammals
24. Expanding Silane-Mediated Coupling Methodologies for the Formation of Medicinally Relevant Structural Motifs Hughes, Isaac 2020 Theses Chemistry, OrganicBiochemistrySilane compoundsSilicates
25. Investigation of Ribonuclease HI handle region dynamics using Solution-state nuclear magnetic resonance spectroscopy, Molecular Dynamic simulations and X-ray crystallography Martin, James Arthur 2020 Theses BiophysicsBiochemistryHIV (Viruses)Mouse leukemia virusesRNAEndonucleasesNuclear magnetic resonance spectroscopy
26. Structural and Biophysical Studies of Hair Cell Mechanotransduction Proteins Dionne, Gilman 2020 Theses BiochemistryBiophysicsHair cellsProteinsCellular signal transduction--Research
27. The Critical Assessment of Protein Dynamics using Molecular Dynamics (MD) Simulations and Nuclear Magnetic Resonance (NMR) Spectroscopy Experimentation Hsu, Andrew 2020 Theses BiophysicsBiochemistryNuclear magnetic resonance spectroscopyMolecular dynamics--Computer simulation
28. The Regulation of Mitochondrial Complex I Biogenesis in Drosophila Flight Muscles Garcia, Christian Joel 2020 Theses PhysiologyBiochemistryDrosophila melanogasterMitochondriaMitochondria--Formation
29. Biomolecular NMR spectroscopy: Application to the study of the piRNA-pathway protein GTSF1, and backbone and side-chain spin relaxation methods development O'Brien, Paul 2019 Theses BiophysicsBiochemistryNuclear magnetic resonance spectroscopyProteins--StructureMolecular dynamics
30. Genetic Mechanisms of Regulated Stochastic Gene Expression Horta, Adan 2019 Theses NeurosciencesBiochemistryGeneticsOlfactory receptor genesGene expressionCadherinsHuman genetics--Variation
31. Liver X Receptor cis-Repression and Cholesterol Efflux Restrain Innate Immunity and Coronary Artery Disease Thomas, David George 2019 Theses CytologyMolecular biologyBiochemistryAtherosclerosis--PreventionImmunityNuclear receptors (Biochemistry)
32. Mechanisms and therapeutic targeting of NT5C2 mutations in relapsed acute lymphoblastic leukemia Dieck, Chelsea 2019 Theses BiochemistryLymphoblastic leukemiaDrug resistanceOncologyMutation (Biology)Molecular biology
33. Molecular Approaches to Targeting Oncogenic KRAS and Ferroptosis Feng, Huizhong 2019 Theses Molecular biologyBiochemistryCytologyBiochemical markersCancerCell death
34. Novel functions of C9ORF72, a gene involved in ALS/FTD Fomin, Vitalay 2019 Theses BiologyBiochemistryGeneticsCytologyAmyotrophic lateral sclerosisFrontotemporal dementiaGene expression
35. Nucleosome Curtains and their application to the study of DNA condensation by condensin Moevus, Corentin Jean 2019 Theses BiochemistryBiophysicsDNACondensed matter
36. Solving Challenging Structures using Single-Particle Cryogenic Electron Microscopy Tan, Yong Zi 2019 Theses BiochemistryBiophysicsElectron microscopyMacromolecules--StructureRibosomesMembrane proteinsCytology--Technique
37. Structural Analyses of the Transient Receptor Potential Channels TRPV3 and TRPV6 McGoldrick, Luke Lawrence Reedy 2019 Theses BiochemistryMolecular biologyTRP channelsStructure-activity relationships (Biochemistry)Ion channels
38. Structural Investigation of Plasmodium falciparum Chloroquine Resistance Transporter in the Context of Anti-Malarial Drug Resistance Kim, Jonathan Young 2019 Theses BiochemistryMalariaDrug resistanceAntimalarialsDrugs--Physiological transport
39. Structural studies of the yeast transcription termination complex Nrd1-Nab3-Sen1 Zhang, Yinglu 2019 Theses BiologyMolecular biologyBiochemistryRNA polymerasesGenetic transcription
40. The Mechanism of NusG-Mediated Transcription-Translation Coupling and The Role of RacR in Transcription Regulation in Escherichia coli Bailey, Elizabeth Jean 2019 Theses BiochemistryMolecular biologyChemistryGenetic transcription--RegulationEscherichia coli
41. Using single molecule magnetic tweezers to dissect titin energy release during muscle contraction Eckels, Edward Charles 2019 Theses BiophysicsBiochemistryPhysiologyMagnetic tweezersMuscle contractionProtein folding
42. Allosteric Coupling, Nucleotide Binding and ATP Hydrolysis by Hsp70 Chaperones on a Structural Basis Wang, Wei 2018 Theses BiologyBiochemistryBiophysicsAllosteric regulationHeat shock proteins
43. Characterization of a novel Ser/Thr kinase/phosphatase pair in Escherichia coli Rajagopalan, Krithika 2018 Theses MicrobiologyBiochemistryPhosphatasesProtein kinasesEscherichia coliSerine
44. Design and Synthesis of 3'-Oxygen-Modified Cleavable Nucleotide Reversible Terminators for Scarless DNA Sequencing by Synthesis Hsieh, Min-Kang 2018 Theses Chemical engineeringBiochemistryBiomedical engineeringNucleotide sequence
45. Development of Single Molecule Electronic SNP Assays using Polymer Tagged Nucleotides and Nanopore Detection Cho, Youngjin 2018 Theses BiochemistryBiomedical engineeringNanoporesSingle nucleotide polymorphisms
46. Dynamic Nuclear Polarization with Biradical Affinity Reagents Rogawski, Rivkah 2018 Theses BiophysicsChemistryBiochemistryPolarization (Nuclear physics)Biradicals
47. Integration of EGFR and LIN-12/Notch signaling in Vulval Precursor Cell fate specification in Caenorhabditis elegans Underwood, Ryan 2018 Theses BiochemistryMetazoaCell interactionCellular signal transductionBiophysics
48. Pathways for kidney triglyceride accumulation Scerbo, Diego 2018 Theses BiologyBiochemistryNutritionTriglyceridesKidneys--Diseases
49. Resonance-energy-transfer-based fluorescence imaging and free energy perturbation calculation Xu, Fang 2018 Theses Chemistry, Physical and theoreticalProtein-protein interactionsFluorescenceEnergy transferBiochemistry
50. Shared Molecular Features of Inherited and Sporadic ALS/FTD Conlon, Erin Grace 2018 Theses BiochemistryGeneticsNeurosciencesAmyotrophic lateral sclerosisFrontotemporal dementiaMolecular biology
51. Structural and biophysical studies of the Drosophila melanogaster Dpr and DIP families Cosmanescu, Filip 2018 Theses BiochemistryNeurosciencesBiophysicsDrosophila melanogasterNeurons
52. Structural and Functional Investigation of Bacterial Membrane Biosynthesis Belcher Dufrisne, Meagan Leigh 2018 Theses BiochemistryBacterial cell walls--SynthesisPhosphoinositidesBiosynthesisEnzymesTuberculosis--TreatmentPeptidoglycansMycoplasmataceae
53. Structural Studies of the Integrator Complex -- pre-UsnRNA 3'-end Processing Machinery Wu, Yixuan 2018 Theses BiologyBiochemistryCatalytic RNA
54. Systematically Mapping the Epigenetic Context Dependence of Transcription Factor Binding Kribelbauer, Judith Franziska 2018 Theses BiochemistryBioinformaticsBiophysicsTranscription factorsGene regulatory networksEpigenetics
55. Targeting neurons with small molecule probes: from imaging to modulation Boltaev, Umed Tolibovich 2018 Theses ChemistryBiochemistryNeurosciencesNeuronsMolecular probes
56. The BARD1 BRCT Domain in Tumor Suppression and Genome Stability Billing, David 2018 Theses Molecular biologyCytologyBiochemistryTumor suppressor proteinsGenomes
57. The Role of Eukaryotic Recombinase Loop L1 During Homologous Recombination Steinfeld, Justin Benjamin 2018 Theses BiophysicsBiochemistryGeneticsGenetic recombinationEukaryotic cells
58. The Role of Modified UNC-68 in Age-related Caenorhabditis elegans Muscle Function Loss Forrester, Frances M. 2018 Theses PhysiologyBiochemistryCaenorhabditis elegansMuscle cells
59. The Saccharomyces cerevisiae Srs2 Helicase Regulates Homologous Recombination through the Disassembly of Recombination Intermediates Kaniecki, Kyle Stephen 2018 Theses GeneticsBiophysicsBiochemistrySaccharomyces cerevisiaeGenetic recombination
60. Artificial Metabolons: Design of Self-Assembled Bio-Complexes Garcia, Kristen E. 2017 Theses Chemical engineeringProteinsBiochemistry
61. Biochemical and Genetic Investigation of Immature Murine Leukemia Virus Assembly Tinaztepe, Sedef 2017 Theses VirologyBiochemistryCytologyMouse leukemia virusesCytoskeletal proteinsRetroviruses
62. Biology of maintenance and de novo methylation mediated by DNA methyltransferase-1 Yarychkivska, Olga 2017 Theses DNA--MethylationMethyltransferasesDNA replicationCell divisionGenomicsGeneticsBiochemistryBiology
63. Cryo-electron microscopy and single particle reconstructions of the Leishmania major ribosome and of the encephalomyocarditis virus internal ribosome entry site bound to the 40S subunit Jobe, Amy Beth 2017 Theses Electron microscopyRibosomesLeishmaniaRNACryoelectronicsBiologyBiochemistryBiophysics
64. Engineering Electron Transfer Processes in Oxidoreductases: Applications in Biocatalysis Ozbakir, Harun Ferit 2017 Theses Chemical engineeringBiochemistryOxidoreductasesBiocatalysis
65. Membrane partitioning by Flotillin-1 facilitates amphetamine-induced dopamine transporter activity Fong, Wendy Mei 2017 Theses BiochemistryNeurosciencesCytologyCell membranesCarrier proteins
66. Nanoscale Electrical and Coarse-grained Molecular Dynamics Studies of Influenza Hemagglutinin-mediated Membrane Fusion Pores Alcott, Brett Eugene 2017 Theses BiophysicsBiochemistryVirologyMolecular dynamicsMembrane fusion
67. PTEN affects gene expression and histone modifications and plays a role in the regulation of transcription Steinbach, Nicole 2017 Theses CytologyBiochemistryOncologyGene expressionGenetic transcription
68. Regulation of Release Factor 2 in Non-canonical Translation Pathways Huang, Bridget Yih Jiin 2017 Theses Bacterial proteinsRibosomesBiochemistryProteins--SynthesisBiophysics
69. RPGRIP1L and FTO – genes implicated in the effects of FTO intronic sequence variants on food intake – also affect adipogenesis and adipocyte biology. Martin-Carli, Jayne Frances 2017 Theses BiochemistryCytologyMolecular biologyObesity--Genetic aspects
70. Single-molecule observations of hRPA, RAD51, and RAD52 on single-stranded DNA Ma, Chu Jian 2017 Theses BiochemistryBiophysicsDNA replicationGenetic recombinationMolecular biology
71. Structural and Functional Studies of TRPML1 and TRPP2 Benvin, Nicole Marie 2017 Theses BiologyBiochemistryBiophysicsTRP channelsProteins--Structure
72. Structural and functional studies on the regulation of pyruvate carboxylase by the bacterial second messenger cyclic-di-AMP Choi, Philip H. 2017 Theses Enzymes--StructureListeria monocytogenesEnzymesPyruvate carboxylaseBiochemistryMicrobiology
73. Chloride Intracellular Channels 1 and 4 function in distinct branches of S1P signaling to regulate endothelial cell behavior and vascular development Jilishitz, Irina 2016 Theses MorphogenesisGrowth factorsNeovascularizationEndothelial cellsMolecular biologyBiochemistry
74. Cryo-electron microscopy studies of dynamical features of ribosomes during the translation process Sun, Ming 2016 Theses BiophysicsProteins--StructureRibosomes--StructureRibosomesCryoelectronicsBiologyBiochemistry
75. Examining the Effects of D-Amino Acids on Translation Fleisher, Rachel Chaya 2016 Theses Messenger RNAAmino acidsAmino acid sequenceRibosomesBiochemistryChemistry
76. Novel Methods for the Ribosomal Incorporation of β-Amino Acids Sanguineti, Gabriella 2016 Theses Amino acidsBiochemistry--MethodologyPeptides--SynthesisBiochemistry
77. Oxidative Folding in Bacteria: Studies Using Single Molecule Force Spectroscopy Kahn, Thomas 2016 Theses Protein foldingOxidoreductasesEscherichia coli--PhysiologyOxidationBiophysicsBiochemistry
78. Role of motor neuron autophagy in a mouse model of Amyotrophic Lateral Sclerosis Rudnick, Noam Daniel 2016 Theses Motor neuronsAutophagic vacuolesAmyotrophic lateral sclerosisNeurosciencesBiochemistryMedicine
79. Structural Studies of a Mammalian Epithelial Calcium Channel Saotome, Kei 2016 Theses Calcium--Physiological effectBiochemistryTRP channelsCalcium channels
80. Understanding complex biomolecular systems through the synergy of molecular dynamics simulations, NMR spectroscopy and X-Ray crystallography Zeiske, Tim 2016 Theses Molecular dynamics--Simulation methodsMolecular dynamics--Computer simulationNuclear magnetic resonance spectroscopyBiomolecules--Computer simulationX-ray crystallographyMacromolecules--StructureMolecular dynamicsBiophysicsBiochemistry
81. Combined Biosynthetic and Synthetic Production of Valuable Molecules: A Hybrid Approach to Vitamin E and Novel Ambroxan Derivatives Adanve, Bertrand Tankpinou 2015 Theses Organic compounds--SynthesisVitamin ESynthetic biologyChemistryBiochemistry
82. Development of Trimethoprim Chemical Tags for Single Molecule Imaging in Live Cells Wang, Tracy Yuh 2015 Theses ChemistryBiochemistry
83. Electrodeposition and Electroless Deposition of Copper in Interconnect Technology and Biotechnology Related Applications Sun, Xiaoxuan 2015 Theses Chemical engineeringChemistryBiochemistry
84. Exploring an Interface Between Synthetic Chemistry and Chemical Biology: The Synthesis of Complex Natural Products and Novel Chemical Probes Thomas, Stephen Basil 2015 Theses Natural products--SynthesisBiochemistryChemistry, OrganicOrganic compounds--SynthesisChemistry
85. Harnessing Growth Selections in Saccharomyces cerevisiae for Biological Engineering Harton, Marie Deborah Gaynelle 2015 Theses Natural selectionSaccharomyces cerevisiae--GeneticsBiomedical engineeringBiochemistry
86. Identification and Biophysical Characterization of Small Molecules Modulating Protein Disulfide Isomerase in Neurodegenerative Diseases Kaplan, Anna 2015 Theses Nervous system--DegenerationNeuroprotective agentsProtein disulfide isomeraseBiophysicsBiochemistryBiology
87. Investigating the role of the RNA binding protein TDP-43 in Amyotrophic Lateral Sclerosis using animal and cell-based models of disease Lehrer, Helaina 2015 Theses Molecular biologyNeurosciencesBiochemistry
88. Protein Structure Dynamics and Function at Micelle and Particle Interfaces Chin, Michael 2015 Theses ChemistryBiochemistryBiophysics
89. Regulation Of Retroviral Silencing In Different Cell Types Wang, Cheng 2015 Theses RetrovirusesCellsMouse leukemia virusesBiochemistryVirology
90. Reprogramming protein synthesis for cell engineering Anzalone, Andrew Vito 2015 Theses Proteins--SynthesisBioengineeringAmino acids--BiotechnologyRNA-protein interactionsSynthetic biologyBiochemistryChemistry, OrganicBiologyMolecular biology
91. Structural Studies of the Fungal pre-mRNA 3'-end Processing Machinery Jurado, Ashley Rae 2015 Theses ProteinsRNA splicingScission (Chemistry)Messenger RNAMolecular biologyBiologyBiochemistry
92. The Regulation of PREX2 by Phosphorylation Barrows, Douglas Walker 2015 Theses PhosphorylationInsulin--Mechanism of actionPhosphoinositidesBiologyBiochemistryPharmacology
93. Winning the cellular lottery: how proteins reach and recognize targets in DNA Redding, Sy Eugene 2015 Theses Promoters (Genetics)DNA-protein interactionsDNA-binding proteinsBiophysicsBiochemistryBiology
94. Engineering a Repeats-in-Toxin Scaffold for Stimulus-Responsive Biotechnology Applications Dooley, Kevin P. 2014 Theses Proteins--StructureChemical engineeringBiochemistryBiomedical engineering
95. Learning from cadherin structures and sequences: affinity determinants and protein architecture Felsovalyi, Klara 2014 Theses Protein bindingCadherinsBiochemistryBioinformaticsBiophysics
96. Molecular Basis for the Recognition of the Regulatory Stem-loop Structures in Eukaryotic Messenger RNAs Tan, Dazhi 2014 Theses Messenger RNARNA-protein interactionsEukaryotic cellsBiologyBiochemistryMolecular biology
97. Structural and biophysical characterization of protocadherin extracellular regions Wolcott, Holly Noelle 2014 Theses BiochemistryBiophysics
98. The role of phosphatidylinositol 3-kinases in autophagy regulation Devereaux, Kelly Anne 2014 Theses Autophagic vacuoleBiochemistryPhosphoinositidesCytologyPathology
99. Understanding two inhibitors of NF-κB: A20 and IκBβ De, Arnab 2014 Theses Glycogen synthase kinase-3NF-kappa B (DNA-binding protein)ImmunologyBiochemistryChemistry
100. Building a Genetic System in Yeast to Search for High Affinity Proteins in Sequence Space Merguerian, Matthew Douglas 2013 Theses Molecular biologyBiochemistryCytologyProtein bindingYeast--GeneticsProtein engineering