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1. Allosteric Coupling, Nucleotide Binding and ATP Hydrolysis by Hsp70 Chaperones on a Structural Basis

Wang, Wei
2018
Theses
BiologyBiochemistryBiophysicsAllosteric regulationHeat shock proteins

2. An Analysis of the Essential Chromatin Factor Zinc Finger Protein 1 (ZFP-1), and a Study of the Involvement of RNAi factors in Histone Processing in Caenorabditis Elegans

Anastasiades Avgousti, Daphne Christina
2012
Theses
BiochemistryBiophysics

3. Application and development of methods towards the target identification of biologically-active small molecules

SriRamaratnam, Rohitha
2011
Theses
ChemistryBiologyMoleculesBiochemistryBiochemical geneticsGene targeting

4. Artificial Metabolons: Design of Self-Assembled Bio-Complexes

Garcia, Kristen E.
2017
Theses
Chemical engineeringProteinsBiochemistry

5. Biochemical and Genetic Investigation of Immature Murine Leukemia Virus Assembly

Tinaztepe, Sedef
2017
Theses
VirologyBiochemistryCytologyMouse leukemia virusesCytoskeletal proteinsRetroviruses

6. Biology of maintenance and de novo methylation mediated by DNA methyltransferase-1

Yarychkivska, Olga
2017
Theses
DNA--MethylationMethyltransferasesDNA replicationCell divisionGenomicsGeneticsBiochemistryBiology

7. Biomolecular NMR spectroscopy: Application to the study of the piRNA-pathway protein GTSF1, and backbone and side-chain spin relaxation methods development

O'Brien, Paul
2019
Theses
BiophysicsBiochemistryNuclear magnetic resonance spectroscopyProteins--StructureMolecular dynamics

8. Building a Genetic System in Yeast to Search for High Affinity Proteins in Sequence Space

Merguerian, Matthew Douglas
2013
Theses
Molecular biologyBiochemistryCytology

9. Characterization of a novel Ser/Thr kinase/phosphatase pair in Escherichia coli

Rajagopalan, Krithika
2018
Theses
MicrobiologyBiochemistryPhosphatasesProtein kinasesEscherichia coliSerine

10. Characterizing the Interaction of the ATP Binding Cassette Transporters (G subfamily) with the Intracellular Protein Lipid Environment

Gulati, Sonia
2011
Theses
BiochemistryMedical sciences

11. Chloride Intracellular Channels 1 and 4 function in distinct branches of S1P signaling to regulate endothelial cell behavior and vascular development

Jilishitz, Irina
2016
Theses
MorphogenesisGrowth factorsNeovascularizationEndothelial cellsMolecular biologyBiochemistry

12. Combined Biosynthetic and Synthetic Production of Valuable Molecules: A Hybrid Approach to Vitamin E and Novel Ambroxan Derivatives

Adanve, Bertrand Tankpinou
2015
Theses
Organic compounds--SynthesisVitamin ESynthetic biologyChemistryBiochemistry

13. Cryo-electron microscopy and single particle reconstructions of the Leishmania major ribosome and of the encephalomyocarditis virus internal ribosome entry site bound to the 40S subunit

Jobe, Amy Beth
2017
Theses
Electron microscopyRibosomesLeishmaniaRNACryoelectronicsBiologyBiochemistryBiophysics

14. Cryo-electron microscopy studies of dynamical features of ribosomes during the translation process

Sun, Ming
2016
Theses
BiophysicsProteins--StructureRibosomes--StructureRibosomesCryoelectronicsBiologyBiochemistry

15. CysZ: Structural and Functional Studies of a Novel Sulfate Transport Protein

Assur, Zahra
2013
Theses
CytologyCarrier proteinsBiochemistryBiophysics

16. Design and Synthesis of 3'-Oxygen-Modified Cleavable Nucleotide Reversible Terminators for Scarless DNA Sequencing by Synthesis

Hsieh, Min-Kang
2018
Theses
Chemical engineeringBiochemistryBiomedical engineeringNucleotide sequence

17. Development of Single Molecule Electronic SNP Assays using Polymer Tagged Nucleotides and Nanopore Detection

Cho, Youngjin
2018
Theses
BiochemistryBiomedical engineeringNanoporesSingle nucleotide polymorphisms

18. Development of Trimethoprim Chemical Tags for Single Molecule Imaging in Live Cells

Wang, Tracy Yuh
2015
Theses
ChemistryBiochemistry

19. Dynamic Nuclear Polarization with Biradical Affinity Reagents

Rogawski, Rivkah
2018
Theses
BiophysicsChemistryBiochemistryPolarization (Nuclear physics)Biradicals

20. Electrodeposition and Electroless Deposition of Copper in Interconnect Technology and Biotechnology Related Applications

Sun, Xiaoxuan
2015
Theses
Chemical engineeringChemistryBiochemistry

21. Engineering a Repeats-in-Toxin Scaffold for Stimulus-Responsive Biotechnology Applications

Dooley, Kevin P.
2014
Theses
Proteins--StructureChemical engineeringBiochemistryBiomedical engineering

22. Engineering Electron Transfer Processes in Oxidoreductases: Applications in Biocatalysis

Ozbakir, Harun Ferit
2017
Theses
Chemical engineeringBiochemistryOxidoreductasesBiocatalysis

23. Examining the Effects of D-Amino Acids on Translation

Fleisher, Rachel Chaya
2016
Theses
Messenger RNAAmino acidsAmino acid sequenceRibosomesBiochemistryChemistry

24. Exploring an Interface Between Synthetic Chemistry and Chemical Biology: The Synthesis of Complex Natural Products and Novel Chemical Probes

Thomas, Stephen Basil
2015
Theses
Natural products--SynthesisBiochemistryChemistry, OrganicOrganic compounds--SynthesisChemistry

25. Ferroptosis: A Novel Form of Cancer Cell Death Induced by the Small Molecule Erastin

Lemberg, Kathryn
2011
Theses
BiologyBiochemistryChemistry

26. Gates and Latches: the mechanochemistry of ATP binding in kinesin 1 and Eg5

Behnke-Parks, William M.
2011
Theses
BiologyBiophysicsBiochemistry

27. Genetic Mechanisms of Regulated Stochastic Gene Expression

Horta, Adan
2019
Theses
NeurosciencesBiochemistryGeneticsOlfactory receptor genesGene expressionCadherinsHuman genetics--Variation

28. Harnessing Growth Selections in Saccharomyces cerevisiae for Biological Engineering

Harton, Marie Deborah Gaynelle
2015
Theses
Natural selectionSaccharomyces cerevisiae--GeneticsBiomedical engineeringBiochemistry

29. I: Catalytic Direct C-H Arylation of Pyrazoles. II: Toward Modulation of Neuroplasticity with Small Molecules

Jacques, Teresa
2013
Theses
ChemistryChemistry, OrganicBiochemistry

30. Identification and Biophysical Characterization of Small Molecules Modulating Protein Disulfide Isomerase in Neurodegenerative Diseases

Kaplan, Anna
2015
Theses
Nervous system--DegenerationNeuroprotective agentsProtein disulfide isomeraseBiophysicsBiochemistryBiology

31. Integration of EGFR and LIN-12/Notch signaling in Vulval Precursor Cell fate specification in Caenorhabditis elegans

Underwood, Ryan
2018
Theses
BiochemistryMetazoaCell interactionCellular signal transductionBiophysics

32. Investigating the role of the RNA binding protein TDP-43 in Amyotrophic Lateral Sclerosis using animal and cell-based models of disease

Lehrer, Helaina
2015
Theses
Molecular biologyNeurosciencesBiochemistry

33. Learning from cadherin structures and sequences: affinity determinants and protein architecture

Felsovalyi, Klara
2014
Theses
Protein bindingCadherinsBiochemistryBioinformaticsBiophysics

34. Ligand-Protein Interactions in Cytochromes

Catalano, Jaclyn
2011
Theses
ChemistryBiochemistryBiophysics

35. Liver X Receptor cis-Repression and Cholesterol Efflux Restrain Innate Immunity and Coronary Artery Disease

Thomas, David George
2019
Theses
CytologyMolecular biologyBiochemistryAtherosclerosis--PreventionImmunityNuclear receptors (Biochemistry)

36. Mechanism of Transcription Arrest By The Nun Protein of Bacteriophage HK022

Vitiello, Christal Lourdes
2012
Theses
MicrobiologyBiochemistryBiology

37. Mechanisms and therapeutic targeting of NT5C2 mutations in relapsed acute lymphoblastic leukemia

Dieck, Chelsea
2019
Theses
BiochemistryLymphoblastic leukemiaDrug resistanceOncologyMutation (Biology)Molecular biology

38. Mechanochemical Methods for Single Molecule Biochemistry and Studies of Thiol-Disulfide Exchange in Proteins

Kosuri, Pallav
2012
Theses
BiophysicsBiochemistryBiology

39. Membrane partitioning by Flotillin-1 facilitates amphetamine-induced dopamine transporter activity

Fong, Wendy Mei
2017
Theses
BiochemistryNeurosciencesCytologyCell membranesCarrier proteins

40. MEMS-based temperature-dependent characterization of biomolecular interactions

Wang, Bin
2012
Theses
Mechanical engineeringBiochemistry

41. Molecular Approaches to Targeting Oncogenic KRAS and Ferroptosis

Feng, Huizhong
2019
Theses
Molecular biologyBiochemistryCytologyBiochemical markersCancerCell death

42. Molecular Basis for the Recognition of the Regulatory Stem-loop Structures in Eukaryotic Messenger RNAs

Tan, Dazhi
2014
Theses
Messenger RNARNA-protein interactionsEukaryotic cellsBiologyBiochemistryMolecular biology

43. Molecular Mechanisms Controlling Synaptic Vesicle Fusion

Radoff, Daniel Todd
2011
Theses
Biochemistry

44. Nanoscale Electrical and Coarse-grained Molecular Dynamics Studies of Influenza Hemagglutinin-mediated Membrane Fusion Pores

Alcott, Brett Eugene
2017
Theses
BiophysicsBiochemistryVirologyMolecular dynamicsMembrane fusion

45. Novel functions of C9ORF72, a gene involved in ALS/FTD

Fomin, Vitalay
2019
Theses
BiologyBiochemistryGeneticsCytologyAmyotrophic lateral sclerosisFrontotemporal dementiaGene expression

46. Novel Methods for the Ribosomal Incorporation of β-Amino Acids

Sanguineti, Gabriella
2016
Theses
Amino acidsBiochemistry--MethodologyPeptides--SynthesisBiochemistry

47. Novel Regulatory Mechanisms of Cytoplasmic Dynein: A Role for the Complex Base

Weil, Sarah J.
2013
Theses
BiologyBiochemistry

48. Nucleosome Curtains and their application to the study of DNA condensation by condensin

Moevus, Corentin Jean
2019
Theses
BiochemistryBiophysicsDNACondensed matter

49. Oxidative Folding in Bacteria: Studies Using Single Molecule Force Spectroscopy

Kahn, Thomas
2016
Theses
Protein foldingOxidoreductasesEscherichia coli--PhysiologyOxidationBiophysicsBiochemistry

50. Pathways for kidney triglyceride accumulation

Scerbo, Diego
2018
Theses
BiologyBiochemistryNutritionTriglyceridesKidneys--Diseases

51. P-REX2 PH Domain Inhibition of PTEN Regulates Transformation, Insulin Signaling, and Glucose Homeostasis

Hodakoski, Cindy Marie
2012
Theses
BiologyBiochemistry

52. Protein Structure Dynamics and Function at Micelle and Particle Interfaces

Chin, Michael
2015
Theses
ChemistryBiochemistryBiophysics

53. PTEN affects gene expression and histone modifications and plays a role in the regulation of transcription

Steinbach, Nicole
2017
Theses
CytologyBiochemistryOncologyGene expressionGenetic transcription

54. PTEN-LONG, a translational variant of the canonical tumor suppressor PTEN

Hopkins, Benjamin
2013
Theses
BiologyBiochemistry

55. Regulation of alternative splicing and its connections to cancer

Chen, Mo
2011
Theses
BiologyMolecular biologyBiochemistry

56. Regulation of Release Factor 2 in Non-canonical Translation Pathways

Huang, Bridget Yih Jiin
2017
Theses
Bacterial proteinsRibosomesBiochemistryProteins--SynthesisBiophysics

57. Regulation Of Retroviral Silencing In Different Cell Types

Wang, Cheng
2015
Theses
RetrovirusesCellsMouse leukemia virusesBiochemistryVirology

58. Reprogramming protein synthesis for cell engineering

Anzalone, Andrew Vito
2015
Theses
Proteins--SynthesisBioengineeringAmino acids--BiotechnologyRNA-protein interactionsSynthetic biologyBiochemistryChemistry, OrganicBiologyMolecular biology

59. Resonance-energy-transfer-based fluorescence imaging and free energy perturbation calculation

Xu, Fang
2018
Theses
Chemistry, Physical and theoreticalProtein-protein interactionsFluorescenceEnergy transferBiochemistry

60. Role of motor neuron autophagy in a mouse model of Amyotrophic Lateral Sclerosis

Rudnick, Noam Daniel
2016
Theses
Motor neuronsAutophagic vacuoleAmyotrophic lateral sclerosisNeurosciencesBiochemistryMedicine

61. RPGRIP1L and FTO – genes implicated in the effects of FTO intronic sequence variants on food intake – also affect adipogenesis and adipocyte biology.

Martin-Carli, Jayne Frances
2017
Theses
BiochemistryCytologyMolecular biologyObesity--Genetic aspects

62. Shared Molecular Features of Inherited and Sporadic ALS/FTD

Conlon, Erin Grace
2018
Theses
BiochemistryGeneticsNeurosciencesAmyotrophic lateral sclerosisFrontotemporal dementiaMolecular biology

63. Single-Molecule Analysis of Ribosome and Initiation Factor Dynamics during the Late Stages of Translation Initiation

MacDougall, Daniel David
2012
Theses
Genetic translationBiochemistryRibosomesBiophysics

64. Single-molecule observations of hRPA, RAD51, and RAD52 on single-stranded DNA

Ma, Chu Jian
2017
Theses
BiochemistryBiophysicsDNA replicationGenetic recombinationMolecular biology

65. Solving Challenging Structures using Single-Particle Cryogenic Electron Microscopy

Tan, Yong Zi
2019
Theses
BiochemistryBiophysicsElectron microscopyMacromolecules--StructureRibosomesMembrane proteinsCytology--Technique

66. Structural Analyses of the Transient Receptor Potential Channels TRPV3 and TRPV6

McGoldrick, Luke Lawrence Reedy
2019
Theses
BiochemistryMolecular biologyTRP channelsStructure-activity relationships (Biochemistry)Ion channels

67. Structural and Biochemical Characterizations of the Symplekin-Ssu72-CTD Complex in Pre-mRNA 3' end Processing

Xiang, Kehui
2013
Theses
BiochemistryGenetic transcriptionRNA polymerasesBiologyMolecular biology

68. Structural and biophysical characterization of protocadherin extracellular regions

Wolcott, Holly Noelle
2014
Theses
BiochemistryBiophysics

69. Structural and biophysical studies of the Drosophila melanogaster Dpr and DIP families

Cosmanescu, Filip
2018
Theses
BiochemistryNeurosciencesBiophysicsDrosophila melanogasterNeurons

70. Structural and Functional Investigation of Bacterial Membrane Biosynthesis

Belcher Dufrisne, Meagan Leigh
2018
Theses
BiochemistryBacterial cell walls--SynthesisPhosphoinositidesBiosynthesisEnzymes

71. Structural and Functional Studies of Biotin-Dependent Carboxylases

Huang, Christine S.
2013
Theses
BiochemistryBiophysics

72. Structural and Functional Studies of TRPML1 and TRPP2

Benvin, Nicole Marie
2017
Theses
BiologyBiochemistryBiophysicsTRP channelsProteins--Structure

73. Structural and functional studies on the regulation of pyruvate carboxylase by the bacterial second messenger cyclic-di-AMP

Choi, Philip H.
2017
Theses
Enzymes--StructureListeria monocytogenesEnzymesPyruvate carboxylaseBiochemistryMicrobiology

74. Structural Investigation of Plasmodium falciparum Chloroquine Resistance Transporter in the Context of Anti-Malarial Drug Resistance

Kim, Jonathan Young
2019
Theses
BiochemistryMalariaDrug resistanceAntimalarialsDrugs--Physiological transport

75. Structural Studies of a Mammalian Epithelial Calcium Channel

Saotome, Kei
2016
Theses
Calcium--Physiological effectBiochemistryTRP channelsCalcium channels

76. Structural Studies of the Fungal pre-mRNA 3'-end Processing Machinery

Jurado, Ashley Rae
2015
Theses
ProteinsRNA splicingScission (Chemistry)Messenger RNAMolecular biologyBiologyBiochemistry

77. Structural Studies of the Integrator Complex -- pre-UsnRNA 3'-end Processing Machinery

Wu, Yixuan
2018
Theses
BiologyBiochemistryCatalytic RNA

78. Structural studies of the yeast transcription termination complex Nrd1-Nab3-Sen1

Zhang, Yinglu
2019
Theses
BiologyMolecular biologyBiochemistryRNA polymerasesGenetic transcription

79. Structure-based Design of Small Molecule Inhibitors of HIV-1 Entry

Le-Khac, Matthew
2013
Theses
BiochemistryPharmacology

80. Studies on mammalian pre-mRNA splicing : connections to transcription and cancer

David, Charles J.
2011
Theses
BiochemistryMolecular biology

81. Systematically Mapping the Epigenetic Context Dependence of Transcription Factor Binding

Kribelbauer, Judith Franziska
2018
Theses
BiochemistryBioinformaticsBiophysicsTranscription factorsGene regulatory networksEpigenetics

82. Targeting neurons with small molecule probes: from imaging to modulation

Boltaev, Umed Tolibovich
2018
Theses
ChemistryBiochemistryNeurosciencesNeuronsMolecular probes

83. The BARD1 BRCT Domain in Tumor Suppression and Genome Stability

Billing, David
2018
Theses
Molecular biologyCytologyBiochemistryTumor suppressor proteinsGenomes

84. The Catalytic Efficiency and Conformational Dynamics of Escherichia coli DNA Repair Enzyme AlkB

Ergel, Burce
2012
Theses
BiochemistryBiophysicsOxidoreductasesCatalysisProteins

85. The Critical Assessment of Protein Dynamics using Molecular Dynamics (MD) Simulations and Nuclear Magnetic Resonance (NMR) Spectroscopy Experimentation

Hsu, Andrew
2020
Theses
BiophysicsBiochemistryNuclear magnetic resonance spectroscopyMolecular dynamics--Computer simulation

86. The Mechanism of NusG-Mediated Transcription-Translation Coupling and The Role of RacR in Transcription Regulation in Escherichia coli

Bailey, Elizabeth Jean
2019
Theses
BiochemistryMolecular biologyChemistryGenetic transcription--RegulationEscherichia coli

87. The Regulation of Mitochondrial Complex I Biogenesis in Drosophila Flight Muscles

Garcia, Christian Joel
2020
Theses
PhysiologyBiochemistryDrosophila melanogasterMitochondriaMitochondria--Formation

88. The Regulation of PREX2 by Phosphorylation

Barrows, Douglas Walker
2015
Theses
PhosphorylationInsulin--Mechanism of actionPhosphoinositidesBiologyBiochemistryPharmacology

89. The Ribosome Discriminates the Structure of the Amino Acid at its Peptidyl-Transferase Center

Englander, Michael Thomas
2011
Theses
Biochemistry

90. Thermal adaptation of conformational dynamics in ribonuclease H

Stafford, Kate
2013
Theses
Biochemistry

91. The Role of Eukaryotic Recombinase Loop L1 During Homologous Recombination

Steinfeld, Justin Benjamin
2018
Theses
BiophysicsBiochemistryGeneticsGenetic recombinationEukaryotic cells

92. The Role of Initiation Factor Dynamics in Translation Initiation

Elvekrog, Margaret Mary
2011
Theses
ChemistryBiophysicsBiochemistry

93. The Role of Modified UNC-68 in Age-related Caenorhabditis elegans Muscle Function Loss

Forrester, Frances M.
2018
Theses
PhysiologyBiochemistryCaenorhabditis elegansMuscle cells

94. The role of phosphatidylinositol 3-kinases in autophagy regulation

Devereaux, Kelly Anne
2014
Theses
Autophagic vacuoleBiochemistryPhosphoinositidesCytologyPathology

95. The Saccharomyces cerevisiae Srs2 Helicase Regulates Homologous Recombination through the Disassembly of Recombination Intermediates

Kaniecki, Kyle Stephen
2018
Theses
GeneticsBiophysicsBiochemistrySaccharomyces cerevisiaeGenetic recombination

96. Towards High-resolution Computational Approaches for Structure-based Drug Discovery

Li, Jianing
2011
Theses
ChemistryChemistry, Physical and theoreticalBiochemistry

97. Trimethoprim-Based Chemical Tags for High Resolution Live Cell Imaging

Jing, Chaoran
2013
Theses
ChemistryBiochemistryCytology

98. Ubiquitin Conformational Dynamics and Hydration Shell Dynamics by Solid State NMR

Huang, Kuo-Ying
2011
Theses
ChemistryBiochemistry

99. Understanding complex biomolecular systems through the synergy of molecular dynamics simulations, NMR spectroscopy and X-Ray crystallography

Zeiske, Tim
2016
Theses
Molecular dynamics--Simulation methodsMolecular dynamics--Computer simulationNuclear magnetic resonance spectroscopyBiomolecules--Computer simulationX-ray crystallographyMacromolecules--StructureMolecular dynamicsBiophysicsBiochemistry

100. Understanding two inhibitors of NF-κB: A20 and IκBβ

De, Arnab
2014
Theses
Glycogen synthase kinase-3NF-kappa B (DNA-binding protein)ImmunologyBiochemistryChemistry
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