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1. Allosteric Coupling, Nucleotide Binding and ATP Hydrolysis by Hsp70 Chaperones on a Structural Basis

Wang, Wei
2018
Theses
BiologyBiochemistryBiophysicsAllosteric regulationHeat shock proteins

2. An Analysis of the Essential Chromatin Factor Zinc Finger Protein 1 (ZFP-1), and a Study of the Involvement of RNAi factors in Histone Processing in Caenorabditis Elegans

Anastasiades Avgousti, Daphne Christina
2012
Theses
BiochemistryBiophysicsCaenorhabditis elegansChromatinHistonesRNANucleosomes

3. A p53-independent role for MDM2-MDMX in cell cycle progression

Klein, Alyssa Michelle
2021
Theses
CytologyMolecular biologyBiochemistryCancerMutation

4. Application and development of methods towards the target identification of biologically-active small molecules

SriRamaratnam, Rohitha
2011
Theses
ChemistryBiologyMoleculesBiochemistryBiochemical geneticsGene targeting

5. Artificial Metabolons: Design of Self-Assembled Bio-Complexes

Garcia, Kristen E.
2017
Theses
Chemical engineeringProteinsBiochemistry

6. Atf5 Links Olfactory Receptor Induced Stress Response to Proper Neuronal Function

Kahiapo, Jerome Keoki
2020
Theses
CytologyBiochemistryMolecular biologyOlfactory receptor genesSmellSensory neuronsMammals

7. Biochemical and Genetic Investigation of Immature Murine Leukemia Virus Assembly

Tinaztepe, Sedef
2017
Theses
VirologyBiochemistryCytologyMouse leukemia virusesCytoskeletal proteinsRetroviruses

8. Biology of maintenance and de novo methylation mediated by DNA methyltransferase-1

Yarychkivska, Olga
2017
Theses
DNA--MethylationMethyltransferasesDNA replicationCell divisionGenomicsGeneticsBiochemistryBiology

9. Biomolecular NMR spectroscopy: Application to the study of the piRNA-pathway protein GTSF1, and backbone and side-chain spin relaxation methods development

O'Brien, Paul
2019
Theses
BiophysicsBiochemistryNuclear magnetic resonance spectroscopyProteins--StructureMolecular dynamics

10. Building a Genetic System in Yeast to Search for High Affinity Proteins in Sequence Space

Merguerian, Matthew Douglas
2013
Theses
Molecular biologyBiochemistryCytology

11. Characterization of a novel Ser/Thr kinase/phosphatase pair in Escherichia coli

Rajagopalan, Krithika
2018
Theses
MicrobiologyBiochemistryPhosphatasesProtein kinasesEscherichia coliSerine

12. Characterizing the Interaction of the ATP Binding Cassette Transporters (G subfamily) with the Intracellular Protein Lipid Environment

Gulati, Sonia
2011
Theses
BiochemistryMedical sciences

13. Chloride Intracellular Channels 1 and 4 function in distinct branches of S1P signaling to regulate endothelial cell behavior and vascular development

Jilishitz, Irina
2016
Theses
MorphogenesisGrowth factorsNeovascularizationEndothelial cellsMolecular biologyBiochemistry

14. Combined Biosynthetic and Synthetic Production of Valuable Molecules: A Hybrid Approach to Vitamin E and Novel Ambroxan Derivatives

Adanve, Bertrand Tankpinou
2015
Theses
Organic compounds--SynthesisVitamin ESynthetic biologyChemistryBiochemistry

15. Cryo-electron microscopy and single particle reconstructions of the Leishmania major ribosome and of the encephalomyocarditis virus internal ribosome entry site bound to the 40S subunit

Jobe, Amy Beth
2017
Theses
Electron microscopyRibosomesLeishmaniaRNACryoelectronicsBiologyBiochemistryBiophysics

16. Cryo-electron microscopy studies of dynamical features of ribosomes during the translation process

Sun, Ming
2016
Theses
BiophysicsProteins--StructureRibosomes--StructureRibosomesCryoelectronicsBiologyBiochemistry

17. CysZ: Structural and Functional Studies of a Novel Sulfate Transport Protein

Assur, Zahra
2013
Theses
CytologyCarrier proteinsBiochemistryBiophysics

18. Design and Synthesis of 3'-Oxygen-Modified Cleavable Nucleotide Reversible Terminators for Scarless DNA Sequencing by Synthesis

Hsieh, Min-Kang
2018
Theses
Chemical engineeringBiochemistryBiomedical engineeringNucleotide sequence

19. Development of Single Molecule Electronic SNP Assays using Polymer Tagged Nucleotides and Nanopore Detection

Cho, Youngjin
2018
Theses
BiochemistryBiomedical engineeringNanoporesSingle nucleotide polymorphisms

20. Development of Trimethoprim Chemical Tags for Single Molecule Imaging in Live Cells

Wang, Tracy Yuh
2015
Theses
ChemistryBiochemistry

21. Directed Evolution of Protein Receptor Binding for Small Molecule Therapeutics Using Fluorescence Polarization

Bannier, Sean David
2021
Theses
ChemistryBiochemistryBiophysicsTetracylcinesProtein bindingPolarization (Light)Yeast

22. Discovery of Novel Ferroptosis Regulators Using Genetic and Lipidomic Analyses

Bezjian, Carla Tara
2021
Theses
CytologyMolecular biologyBiochemistryCell deathGenetic regulationPhospholipids

23. Dynamic Nuclear Polarization with Biradical Affinity Reagents

Rogawski, Rivkah
2018
Theses
BiophysicsChemistryBiochemistryPolarization (Nuclear physics)Biradicals

24. Electrodeposition and Electroless Deposition of Copper in Interconnect Technology and Biotechnology Related Applications

Sun, Xiaoxuan
2015
Theses
Chemical engineeringChemistryBiochemistry

25. Engineering a Repeats-in-Toxin Scaffold for Stimulus-Responsive Biotechnology Applications

Dooley, Kevin P.
2014
Theses
Proteins--StructureChemical engineeringBiochemistryBiomedical engineering

26. Engineering Electron Transfer Processes in Oxidoreductases: Applications in Biocatalysis

Ozbakir, Harun Ferit
2017
Theses
Chemical engineeringBiochemistryOxidoreductasesBiocatalysis

27. Examining the Effects of D-Amino Acids on Translation

Fleisher, Rachel Chaya
2016
Theses
Messenger RNAAmino acidsAmino acid sequenceRibosomesBiochemistryChemistry

28. Expanding Silane-Mediated Coupling Methodologies for the Formation of Medicinally Relevant Structural Motifs

Hughes, Isaac
2020
Theses
Chemistry, OrganicBiochemistrySilane compounds

29. Exploring an Interface Between Synthetic Chemistry and Chemical Biology: The Synthesis of Complex Natural Products and Novel Chemical Probes

Thomas, Stephen Basil
2015
Theses
Natural products--SynthesisBiochemistryChemistry, OrganicOrganic compounds--SynthesisChemistry

30. Ferroptosis: A Novel Form of Cancer Cell Death Induced by the Small Molecule Erastin

Lemberg, Kathryn
2011
Theses
BiologyBiochemistryChemistryApoptosisCell deathCancer

31. Gates and Latches: the mechanochemistry of ATP binding in kinesin 1 and Eg5

Behnke-Parks, William M.
2011
Theses
BiologyBiophysicsBiochemistryKinesinMechanical chemistryCell division

32. Genetic Mechanisms of Regulated Stochastic Gene Expression

Horta, Adan
2019
Theses
NeurosciencesBiochemistryGeneticsOlfactory receptor genesGene expressionCadherinsHuman genetics--Variation

33. Harnessing Growth Selections in Saccharomyces cerevisiae for Biological Engineering

Harton, Marie Deborah Gaynelle
2015
Theses
Natural selectionSaccharomyces cerevisiae--GeneticsBiomedical engineeringBiochemistry

34. How to steal ribosomes: structural studies of two different internal ribosome entry sites

Neupane, Ritam
2021
Theses
BiochemistryBiophysicsVirologyRibosomesEukaryotic cells

35. I: Catalytic Direct C-H Arylation of Pyrazoles. II: Toward Modulation of Neuroplasticity with Small Molecules

Jacques, Teresa
2013
Theses
ChemistryChemistry, OrganicBiochemistry

36. Identification and Biophysical Characterization of Small Molecules Modulating Protein Disulfide Isomerase in Neurodegenerative Diseases

Kaplan, Anna
2015
Theses
Nervous system--DegenerationNeuroprotective agentsProtein disulfide isomeraseBiophysicsBiochemistryBiology

37. Integration of EGFR and LIN-12/Notch signaling in Vulval Precursor Cell fate specification in Caenorhabditis elegans

Underwood, Ryan
2018
Theses
BiochemistryMetazoaCell interactionCellular signal transductionBiophysics

38. Investigating the role of the RNA binding protein TDP-43 in Amyotrophic Lateral Sclerosis using animal and cell-based models of disease

Lehrer, Helaina
2015
Theses
Molecular biologyNeurosciencesBiochemistry

39. Investigation of Ribonuclease HI handle region dynamics using Solution-state nuclear magnetic resonance spectroscopy, Molecular Dynamic simulations and X-ray crystallography

Martin, James Arthur
2020
Theses
BiophysicsBiochemistryHIV (Viruses)Mouse leukemia virusesRNAEndonucleasesNuclear magnetic resonance spectroscopy

40. Learning from cadherin structures and sequences: affinity determinants and protein architecture

Felsovalyi, Klara
2014
Theses
Protein bindingCadherinsBiochemistryBioinformaticsBiophysics

41. Ligand-Protein Interactions in Cytochromes

Catalano, Jaclyn
2011
Theses
ChemistryBiochemistryBiophysics

42. Lipids on Fire: Identifying and Targeting Subcellular Membranes that Drive Ferroptosis

Von Krusenstiern, Alfred Nikolai
2022
Theses
BiochemistryCell deathLipids--PeroxidationCancer--TreatmentEndoplasmic reticulumFatty acidsRaman effectConfocal fluorescence microscopy

43. Liver X Receptor cis-Repression and Cholesterol Efflux Restrain Innate Immunity and Coronary Artery Disease

Thomas, David George
2019
Theses
CytologyMolecular biologyBiochemistryAtherosclerosis--PreventionImmunityNuclear receptors (Biochemistry)

44. Mechanism of Transcription Arrest By The Nun Protein of Bacteriophage HK022

Vitiello, Christal Lourdes
2012
Theses
MicrobiologyBiochemistryBiology

45. Mechanisms and therapeutic targeting of NT5C2 mutations in relapsed acute lymphoblastic leukemia

Dieck, Chelsea
2019
Theses
BiochemistryLymphoblastic leukemiaDrug resistanceOncologyMutation (Biology)Molecular biology

46. Mechanochemical Methods for Single Molecule Biochemistry and Studies of Thiol-Disulfide Exchange in Proteins

Kosuri, Pallav
2012
Theses
BiophysicsBiochemistryBiology

47. Membrane partitioning by Flotillin-1 facilitates amphetamine-induced dopamine transporter activity

Fong, Wendy Mei
2017
Theses
BiochemistryNeurosciencesCytologyCell membranesCarrier proteins

48. MEMS-based temperature-dependent characterization of biomolecular interactions

Wang, Bin
2012
Theses
Mechanical engineeringBiochemistry

49. Molecular Approaches to Targeting Oncogenic KRAS and Ferroptosis

Feng, Huizhong
2019
Theses
Molecular biologyBiochemistryCytologyBiochemical markersCancerCell death

50. Molecular Basis for the Recognition of the Regulatory Stem-loop Structures in Eukaryotic Messenger RNAs

Tan, Dazhi
2014
Theses
Messenger RNARNA-protein interactionsEukaryotic cellsBiologyBiochemistryMolecular biology

51. Molecular Mechanisms Controlling Synaptic Vesicle Fusion

Radoff, Daniel Todd
2011
Theses
BiochemistrySynaptic vesiclesCell membranesMembrane proteins

52. Nanoscale Electrical and Coarse-grained Molecular Dynamics Studies of Influenza Hemagglutinin-mediated Membrane Fusion Pores

Alcott, Brett Eugene
2017
Theses
BiophysicsBiochemistryVirologyMolecular dynamicsMembrane fusion

53. Novel Functions for Dynein Adaptor RILP in Neuronal Autophagy

Khobrekar, Noopur V.
2021
Theses
BiologyBiochemistryDyneinAutophagic vacuolesCell organelles

54. Novel functions of C9ORF72, a gene involved in ALS/FTD

Fomin, Vitalay
2019
Theses
BiologyBiochemistryGeneticsCytologyAmyotrophic lateral sclerosisFrontotemporal dementiaGene expression

55. Novel Methods for the Ribosomal Incorporation of β-Amino Acids

Sanguineti, Gabriella
2016
Theses
Amino acidsBiochemistry--MethodologyPeptides--SynthesisBiochemistry

56. Novel Regulatory Mechanisms of Cytoplasmic Dynein: A Role for the Complex Base

Weil, Sarah J.
2013
Theses
BiologyBiochemistry

57. Nucleosome Curtains and their application to the study of DNA condensation by condensin

Moevus, Corentin Jean
2019
Theses
BiochemistryBiophysicsDNACondensed matter

58. Oxidative Folding in Bacteria: Studies Using Single Molecule Force Spectroscopy

Kahn, Thomas
2016
Theses
Protein foldingOxidoreductasesEscherichia coli--PhysiologyOxidationBiophysicsBiochemistry

59. Pathways for kidney triglyceride accumulation

Scerbo, Diego
2018
Theses
BiologyBiochemistryNutritionTriglyceridesKidneys--Diseases

60. P-REX2 PH Domain Inhibition of PTEN Regulates Transformation, Insulin Signaling, and Glucose Homeostasis

Hodakoski, Cindy Marie
2012
Theses
BiologyBiochemistry

61. Protein Structure Dynamics and Function at Micelle and Particle Interfaces

Chin, Michael
2015
Theses
ChemistryBiochemistryBiophysics

62. PTEN affects gene expression and histone modifications and plays a role in the regulation of transcription

Steinbach, Nicole
2017
Theses
CytologyBiochemistryOncologyGene expressionGenetic transcription

63. PTEN-LONG, a translational variant of the canonical tumor suppressor PTEN

Hopkins, Benjamin
2013
Theses
BiologyBiochemistryTumor suppressor proteinsAdenocarcinomaPancreas--Cancer--Research

64. Regulation of alternative splicing and its connections to cancer

Chen, Mo
2011
Theses
BiologyMolecular biologyBiochemistryRNA splicingPyruvate kinaseCancer cellsExons (Genetics)Mammals--Genetics

65. Regulation of Release Factor 2 in Non-canonical Translation Pathways

Huang, Bridget Yih Jiin
2017
Theses
Bacterial proteinsRibosomesBiochemistryProteins--SynthesisBiophysics

66. Regulation Of Retroviral Silencing In Different Cell Types

Wang, Cheng
2015
Theses
RetrovirusesCellsMouse leukemia virusesBiochemistryVirology

67. Reprogramming protein synthesis for cell engineering

Anzalone, Andrew Vito
2015
Theses
Proteins--SynthesisBioengineeringAmino acids--BiotechnologyRNA-protein interactionsSynthetic biologyBiochemistryChemistry, OrganicBiologyMolecular biology

68. Resonance-energy-transfer-based fluorescence imaging and free energy perturbation calculation

Xu, Fang
2018
Theses
Chemistry, Physical and theoreticalProtein-protein interactionsFluorescenceEnergy transferBiochemistry

69. Role of motor neuron autophagy in a mouse model of Amyotrophic Lateral Sclerosis

Rudnick, Noam Daniel
2016
Theses
Motor neuronsAutophagic vacuoleAmyotrophic lateral sclerosisNeurosciencesBiochemistryMedicine

70. RPGRIP1L and FTO – genes implicated in the effects of FTO intronic sequence variants on food intake – also affect adipogenesis and adipocyte biology.

Martin-Carli, Jayne Frances
2017
Theses
BiochemistryCytologyMolecular biologyObesity--Genetic aspects

71. Shared Molecular Features of Inherited and Sporadic ALS/FTD

Conlon, Erin Grace
2018
Theses
BiochemistryGeneticsNeurosciencesAmyotrophic lateral sclerosisFrontotemporal dementiaMolecular biology

72. Single-Molecule Analysis of Ribosome and Initiation Factor Dynamics during the Late Stages of Translation Initiation

MacDougall, Daniel David
2012
Theses
Genetic translationBiochemistryRibosomesBiophysics

73. Single-molecule observations of hRPA, RAD51, and RAD52 on single-stranded DNA

Ma, Chu Jian
2017
Theses
BiochemistryBiophysicsDNA replicationGenetic recombinationMolecular biology

74. Solving Challenging Structures using Single-Particle Cryogenic Electron Microscopy

Tan, Yong Zi
2019
Theses
BiochemistryBiophysicsElectron microscopyMacromolecules--StructureRibosomesMembrane proteinsCytology--Technique

75. Structural Analyses of the Transient Receptor Potential Channels TRPV3 and TRPV6

McGoldrick, Luke Lawrence Reedy
2019
Theses
BiochemistryMolecular biologyTRP channelsStructure-activity relationships (Biochemistry)Ion channels

76. Structural and Biochemical Characterizations of the Symplekin-Ssu72-CTD Complex in Pre-mRNA 3' end Processing

Xiang, Kehui
2013
Theses
BiochemistryGenetic transcriptionRNA polymerasesBiologyMolecular biology

77. Structural and Biochemical Studies of the Human pre-mRNA 3’-end Processing Complex

Hamilton, Keith
2021
Theses
BiochemistryBiophysicsMessenger RNA--AnalysisMutagenesis

78. Structural and biophysical characterization of protocadherin extracellular regions

Wolcott, Holly Noelle
2014
Theses
BiochemistryBiophysics

79. Structural and Biophysical Studies of Hair Cell Mechanotransduction Proteins

Dionne, Gilman
2020
Theses
BiochemistryBiophysicsProteinsCellular signal transduction--Research

80. Structural and biophysical studies of the Drosophila melanogaster Dpr and DIP families

Cosmanescu, Filip
2018
Theses
BiochemistryNeurosciencesBiophysicsDrosophila melanogasterNeurons

81. Structural and functional characterization of the retinol-binding protein receptor STRA6

Costabile, Brianna Kay
2021
Theses
BiochemistryEpitheliumVitamin A deficiencyVitamin APlacentaChoroid plexusElectron microscopyCalmodulin--Physiological effectZebra danio

82. Structural and Functional Investigation of Bacterial Membrane Biosynthesis

Belcher Dufrisne, Meagan Leigh
2018
Theses
BiochemistryBacterial cell walls--SynthesisPhosphoinositidesBiosynthesisEnzymesTuberculosis--TreatmentPeptidoglycansMycoplasmataceae

83. Structural and Functional Studies of Biotin-Dependent Carboxylases

Huang, Christine S.
2013
Theses
BiochemistryBiophysics

84. Structural and Functional Studies of TRPML1 and TRPP2

Benvin, Nicole Marie
2017
Theses
BiologyBiochemistryBiophysicsTRP channelsProteins--Structure

85. Structural and functional studies on the regulation of pyruvate carboxylase by the bacterial second messenger cyclic-di-AMP

Choi, Philip H.
2017
Theses
Enzymes--StructureListeria monocytogenesEnzymesPyruvate carboxylaseBiochemistryMicrobiology

86. Structural Investigation of Plasmodium falciparum Chloroquine Resistance Transporter in the Context of Anti-Malarial Drug Resistance

Kim, Jonathan Young
2019
Theses
BiochemistryMalariaDrug resistanceAntimalarialsDrugs--Physiological transport

87. Structural Studies of a Mammalian Epithelial Calcium Channel

Saotome, Kei
2016
Theses
Calcium--Physiological effectBiochemistryTRP channelsCalcium channels

88. Structural Studies of the Fungal pre-mRNA 3'-end Processing Machinery

Jurado, Ashley Rae
2015
Theses
ProteinsRNA splicingScission (Chemistry)Messenger RNAMolecular biologyBiologyBiochemistry

89. Structural Studies of the Integrator Complex -- pre-UsnRNA 3'-end Processing Machinery

Wu, Yixuan
2018
Theses
BiologyBiochemistryCatalytic RNA

90. Structural studies of the yeast transcription termination complex Nrd1-Nab3-Sen1

Zhang, Yinglu
2019
Theses
BiologyMolecular biologyBiochemistryRNA polymerasesGenetic transcription

91. Structural studies on bestrophin anion channels by cryogenic electron microscopy

Owji, Aaron Paul
2022
Theses
BiophysicsBiochemistryEye--PhysiologyChloride channelsKlebsiella pneumoniaeMammalsMutagenesis

92. Structure and Function of a Transposon-Encoded CRISPR-Cas System

Halpin-Healy, Tyler Sheehan
2021
Theses
BiochemistryBiophysicsMolecular biologyVibrio choleraeRNADNA

93. Structure-based Design of Small Molecule Inhibitors of HIV-1 Entry

Le-Khac, Matthew
2013
Theses
BiochemistryPharmacology

94. Studies on mammalian pre-mRNA splicing : connections to transcription and cancer

David, Charles J.
2011
Theses
BiochemistryMolecular biologyRNA splicingCancer--Genetic aspectsCancer cellsMammals--GeneticsGlycolysis

95. Systematically Mapping the Epigenetic Context Dependence of Transcription Factor Binding

Kribelbauer, Judith Franziska
2018
Theses
BiochemistryBioinformaticsBiophysicsTranscription factorsGene regulatory networksEpigenetics

96. Targeting neurons with small molecule probes: from imaging to modulation

Boltaev, Umed Tolibovich
2018
Theses
ChemistryBiochemistryNeurosciencesNeuronsMolecular probes

97. The BARD1 BRCT Domain in Tumor Suppression and Genome Stability

Billing, David
2018
Theses
Molecular biologyCytologyBiochemistryTumor suppressor proteinsGenomes

98. The Catalytic Efficiency and Conformational Dynamics of Escherichia coli DNA Repair Enzyme AlkB

Ergel, Burce
2012
Theses
BiochemistryBiophysicsOxidoreductasesCatalysisProteins

99. The Critical Assessment of Protein Dynamics using Molecular Dynamics (MD) Simulations and Nuclear Magnetic Resonance (NMR) Spectroscopy Experimentation

Hsu, Andrew
2020
Theses
BiophysicsBiochemistryNuclear magnetic resonance spectroscopyMolecular dynamics--Computer simulation

100. The Mechanism of NusG-Mediated Transcription-Translation Coupling and The Role of RacR in Transcription Regulation in Escherichia coli

Bailey, Elizabeth Jean
2019
Theses
BiochemistryMolecular biologyChemistryGenetic transcription--RegulationEscherichia coli