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1. Discovery and Optimization of Novel Small-Molecule Inhibitors of Glutathione Peroxidase 4

Lin, Annie
2023
Theses
BiologyDrug resistance in cancer cellsCell deathGlutathioneCancer cells--Effect of drugs on

2. Regulation of EGFR signal transduction and cell division in quiescent Vulval Precursor Cells during dauer developmental arrest

O'Keeffe, Catherine
2023
Theses
BiologyDevelopmental biologyCaenorhabditis elegansStem cellsVulvaCell division

3. The Role of Kinesins in Cell Fate Determination During Neurogenesis

Helmer, Paige
2023
Theses
BiologyKinesinNeurogeneticsNeuronsBrain--PhysiologyMammals--Nervous systemNeuroglia

4. Auditory Tuning in Vocal Learning Songbirds

Yeh, Yow-Tyng
2022
Theses
BiologyNeurosciencesSongbirdsBirds--VocalizationBirdsongsSensorimotor cortex

5. Cardiomyopathy at the Intersection of Stem Cells and Tissue Engineering

Wang, Bryan Zicheng
2022
Theses
BiologyMyocardium--DiseasesStem cellsGene editingTissue engineeringHeart--Diseases--Genetic aspects

6. Development of genetically intact bioengineered spores of Bacillus subtilis

Flores Quijano, Juan Manuel de Jesus
2022
Theses
BiologyBacillus subtilis--GeneticsPlasmids--GeneticsBiotechnologyNatural pesticidesProbiotics

7. Expression and Functional Analyses of the Entire Cadherin Gene Family in C. elegans

Majeed, Maryam
2022
Theses
BiologyNeurosciencesCaenorhabditis elegans--GeneticsGene expressionCadherins

8. Understanding and Engineering Multicomponent Living Systems: Examples from Synthetic Genomics and Engineered Living Materials

McBee, Andrew Ross MacKay
2022
Theses
BiologySynthetic biologyGenomicsMetazoaAmino acidsValineMycelium

9. A Comparative Analysis of Genome Rearrangement in Ciliates

Feng, Yi
2021
Theses
BiologyBioinformaticsEvolution (Biology)Gene rearrangementCiliata--GeneticsEuplotesGenetic code

10. Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements

Murphy, David
2021
Theses
GeneticsEvolution (Biology)BiologyHuman genomeBiodiversity

11. Disentangling mutation and selection in human genetic variation: promises and pitfalls

Agarwal, Ipsita
2021
Theses
BiologyGeneticsEvolution (Biology)Mutation (Biology)Human genomeExomes

12. Electromechanical Coupling in Cells and Its Effects on Membrane Tension and Conductance

Jones Molina, John Anthony
2021
Theses
BiophysicsCytologyBiologyCell membranes

13. Framework for Mapping Gene Regulation via Single-cell Genetic Screens

Tan, Xiangtian
2021
Theses
BiologyCytologyGenetic transcription--RegulationCancer cellsProteins--Analysis

14. Function and Regulation of ALS/FTD-associated RNA Binding Protein FUS

Tsai, Yueh-Lin
2021
Theses
BiologyCytologyMolecular biologyRNA-protein interactionsAmyotrophic lateral sclerosisDementia

15. Mutagenic Repair Outcomes of DNA Double-Strand Breaks

Al-Zain, Amr M.
2021
Theses
BiologyMolecular biologyDouble-stranded RNACancer--EtiologyCancer--Genetic aspectsGenomesMutagenesis

16. Novel Functions for Dynein Adaptor RILP in Neuronal Autophagy

Khobrekar, Noopur V.
2021
Theses
BiologyBiochemistryDyneinAutophagic vacuolesCell organelles

17. Regulation of heterochromatin formation by the JmjC-domain protein Epe1

Bao, Kehan
2021
Theses
BiologyEukaryotic cells--GeneticsHeterochromatinChromatinDNA

18. Role of Mu-Opioid Receptors in the Behavioral Effects of the Antidepressant Tianeptine

Han, Jaena
2021
Theses
BiologyNeurosciencesDepression, Mental--TreatmentAntidepressantsSerotonin uptake inhibitorsMice

19. Structural Studies of NediV-IRES-Mediated Translation Initiation

Altomare, Clara Gilda
2021
Theses
BiologyVirusesRNA virusesRibosomesEukaryotic cellsGenetic translation

20. Adipocytes Secrete Lipid-Laden Exosomes and Influence Local Macrophage Behavior

Flaherty, Stephen
2020
Theses
BiologyLipaseMacrophagesFat cellsAdipose tissues--Analysis

21. Elucidating the abilities of MDM2, MDMX and p21 to regulate ferroptosis

Venkatesh, Divya
2020
Theses
BiologyGeneticsLipids--PeroxidationCell deathCancer

22. Hierarchical Modularity in the Reassembly of Hydra’s Nervous System

Lovas, Jonathan Roek
2020
Theses
NeurosciencesDevelopmental biologyBiologyHydraNeural circuitry

23. Landscape of the p53 transcriptome and clinical implications

Regunath, Kausik
2020
Theses
BiologyGenomesCancer--Genetic aspectsTumors

24. Light and Temperature Cues Elicit Metabolic Reprogramming in the Non-phototrophic Bacterium Pseudomonas aeruginosa

Kahl, Lisa Juliane
2020
Theses
BiologyMicrobiologyMetabolismBiological rhythmsPhotobiologyBacteria--PhysiologyRespiration

25. Predicting Autonomous Promoter Activity Based on Genome-wide Modeling of Massively Parallel Reporter Data

FitzPatrick, Vincent Drury
2020
Theses
BiologyStatisticsPromoters (Genetics)Genomics--Statistical methodsGenetic polymorphisms

26. Screening Whole-Genome Sequenced Strains to Investigate Genetic Determinants of Gentle Touch Sensitivity in Caenorhabditis elegans

Lawry, Stephanie Terese
2020
Theses
GeneticsBiologyGenomicsGenomesNematodesTouchNeurosciences

27. Sexually Dimorphic Development of the Caenorhabditis elegans Nervous System

Bayer, Emily Ann
2020
Theses
BiologyCaenorhabditis elegansSexual dimorphism (Animals)Genetic sex determinationTranscription factorsNervous system

28. Single-particle cryo-electron microscopy studies of ribosomes with fragmented 28S rRNA

Gutierrez-Vargas, Cristina
2020
Theses
BiologyStructural bioinformaticsRibosomes--StructureRNATrypanosoma cruziFragmentation reactions

29. The Neural Basis of Sugar and Fat Cravings

Tan, Hwei-Ee
2020
Theses
NeurosciencesBiologySugarGlucoseFatAppetite

30. Applying medicinal chemistry principles to the Olfactory Code

Tahirova, Narmin Tahir
2019
Theses
BiologyNeurosciencesChemistryOlfactory receptorsPharmaceutical chemistry

31. Computational and Imaging Methods for Studying Neuronal Populations during Behavior

Han, Shuting
2019
Theses
BiologyNeurosciencesMachine learningBrain--ImagingNeuropsychiatryAnimal behaviorNeurons

32. Life history effects on neutral polymorphism and divergence rates, in autosomes and sex chromosomes

Amster, Guy
2019
Theses
BiologySex chromosomesGenetic polymorphismsPopulation geneticsChromosomesBiodiversity

33. Novel functions of C9ORF72, a gene involved in ALS/FTD

Fomin, Vitalay
2019
Theses
BiologyBiochemistryGeneticsCytologyAmyotrophic lateral sclerosisFrontotemporal dementiaGene expression

34. Population Genetics of Mutation Load and Quantitative Traits in Humans

Simons, Yuval Benjamin
2019
Theses
GeneticsBiologyHuman population geneticsMutation (Biology)

35. Quantifying spatiotemporal dynamics of human gut microbiota and metabolic limitations of cancer cell growth

Ji, Brian
2019
Theses
BiologyBiological systemsCancer cells--Growth--RegulationGastrointestinal system--MicrobiologyCell metabolism

36. Quantitative trait variation and adaptation in contemporary humans

Mostafavi, Hakhamanesh
2019
Theses
BiologyGeneticsHuman evolutionGenomes--Data processingHuman genetics--VariationMortality

37. Structural studies of the yeast transcription termination complex Nrd1-Nab3-Sen1

Zhang, Yinglu
2019
Theses
BiologyMolecular biologyBiochemistryRNA polymerasesGenetic transcription

38. Studies on RNA Regulation: From Enhancer RNAs to RBBP6 Isoform3

Chen, Yaqiong
2019
Theses
Molecular biologyRNAGenetic regulationBiology

39. Allosteric Coupling, Nucleotide Binding and ATP Hydrolysis by Hsp70 Chaperones on a Structural Basis

Wang, Wei
2018
Theses
BiologyBiochemistryBiophysicsAllosteric regulationHeat shock proteins

40. Investigating The Role Of Signaling Pathways In Adult Stem Cells Governed By Population Asymmetry

Melamed, David Eric
2018
Theses
BiologyCellular signal transductionAdult stem cells

41. Markers and Mechanisms of β-cell Dedifferentiation

Fan, Jason Chen
2018
Theses
MedicineBiologyCytologyPancreatic beta cells

42. Metabolic Strategies to Cope with Overcrowding in a Pseudomonas aeruginosa Biofilm

Jo, Jeanyoung
2018
Theses
BiologyMicrobiologyPseudomonas aeruginosaBiofilmsMicrobial respiration

43. Multi-level analysis of regulation of EGFR signalling during Drosophila melanogaster leg proximal-distal axis patterning

Newcomb, Susan Elizabeth
2018
Theses
BiologyGeneticsGrowth factors--ReceptorsEpidermal growth factorDrosophila melanogaster

44. On the Role of Sensory Cancellation and Corollary Discharge in Neural Coding and Behavior

Enikolopov, Armen
2018
Theses
NeurosciencesBiologySensory stimulationCochlear nucleus

45. Spatially restricted regulation of cell competition by the cytokine Spaetzle

Alpar, Elif Lale
2018
Theses
BiologyGeneticsCytokinesCells--Growth--Regulation

46. Structural Studies of the Integrator Complex -- pre-UsnRNA 3'-end Processing Machinery

Wu, Yixuan
2018
Theses
BiologyBiochemistryCatalytic RNA

47. The Molecular Mechanism of Replication Independent Repair of DNA Interstrand Crosslinks

Kato, Niyo
2018
Theses
BiologyGeneticsDNA repairCrosslinking (Polymerization)Molecular biology

48. The Mre11-Rad50-Xrs2 Complex in the DNA Damage Response

Oh, Julyun
2018
Theses
BiologyGeneticsMolecular biologyDNA damageDNA repair

49. The Physical State of Water in Dormant Bacteria

DeLay, Michael
2018
Theses
BiophysicsBacteriaBacterial sporesWaterBiology

50. Understand Biology Using Single Cell RNA-Sequencing

Ding, Hongxu
2018
Theses
BiologyNucleotide sequenceSystems biology