WEBVTT Kind: captions Language: en 00:00:00.080 --> 00:00:06.720 So my name is Kollbe Ahn. I'm a CEO of  ACetachol and we are- I'm going to present   00:00:07.760 --> 00:00:12.400 what we- our research area the  project that we have funded by   00:00:12.400 --> 00:00:16.320 NSF SBIR [National Science Foundation  Small Business Innovation Research]. 00:00:16.320 --> 00:00:25.520 Next please. Yeah and the- my company started  in 2016 when I was a faculty at UC Santa Barbara   00:00:26.640 --> 00:00:29.840 based on the surface treatment  technology inspired by   00:00:31.680 --> 00:00:38.160 marine bio organisms and  when pandemic started next 00:00:39.040 --> 00:00:41.600 We thought we can help to address the pandemic   00:00:42.640 --> 00:00:52.720 by introducing our- by applying our surface  treatment technology for many surfaces because   00:00:52.720 --> 00:00:59.760 we can make anti-microbial surface to kill the  viruses and bacteria on content continuously.   00:01:00.880 --> 00:01:06.640 And we know that CDC [Centers for Disease Control  and Prevention] wasn't very helpful because they   00:01:06.640 --> 00:01:15.680 are also some sort of in the confusion that they  said we don't need mask in the beginning, but it's   00:01:16.480 --> 00:01:23.280 common sense that covering your face when you're  coughing or when you're sick is absolutely common   00:01:23.280 --> 00:01:30.480 sense, but they were confusing. And they  also said we have to wash our hand more   00:01:30.480 --> 00:01:36.800 and they also we- they gave us a direction  that we need to hand at least 20 seconds,   00:01:37.360 --> 00:01:44.640 but they did not give us how to sanitize your  hand with sanitizer. Because our core sanitizer   00:01:44.640 --> 00:01:51.920 are 80 percent in the US and in the world used in  this pandemic, but it's only effective when you   00:01:53.520 --> 00:02:00.960 keep your hands wet in our core for 15 seconds.  But most of the people use our core hand sanitizer   00:02:00.960 --> 00:02:06.320 and they apply it. After two seconds, they try  to dry up because they don't want this right.   00:02:06.320 --> 00:02:15.520 Then your hand is not sanitized so- And  contact transmission was one of the major   00:02:16.480 --> 00:02:22.320 route of this pandemic and infection because you  touch the surface after you touch in your face   00:02:22.320 --> 00:02:33.920 or eyes and it's just- but I think so- We instead  try to you know explain to government officials   00:02:33.920 --> 00:02:43.920 or CDC rather we decide to provide better  product that people can use on their hand or   00:02:43.920 --> 00:02:52.560 as a disinfectant on the surface that the coating  can kill virus in bacteria continuously so that   00:02:52.560 --> 00:02:59.040 they don't need to worry about those instructions  so. And also before pandemic we have the pandemic,   00:02:59.040 --> 00:03:05.920 there were like more than hundreds and thousands  people died by secondary infection from hospital   00:03:05.920 --> 00:03:12.960 or from infected from friends and family. It  was there. It wasn't- it's not new. It was   00:03:12.960 --> 00:03:21.280 there already and then and we need to address  these issues you know continuous. So next. 00:03:23.200 --> 00:03:32.160 So but current approach is for you  know treat those patients especially   00:03:32.160 --> 00:03:37.520 in ICU [intensive care unit] was using you know  biocide releasing coating. There's potentially   00:03:38.640 --> 00:03:46.480 genotoxic and cytotoxic and also it takes longer  time to kill germs. Another approach that people   00:03:46.480 --> 00:03:54.000 taking is cationic polymer coating that the people  use right now and all the 24-hour protection   00:03:54.880 --> 00:04:00.800 disinfectant and sanitizers in the market uses  this single charged cationic polymer coating,   00:04:00.800 --> 00:04:06.640 but I will show you the result layer is not  very effective. So our approach here was to   00:04:07.280 --> 00:04:13.840 provide much more effective and  inexpensive surface coating that is   00:04:14.560 --> 00:04:21.120 two charges: Gemini charges ammonium  compound that is like orders of magnitude   00:04:21.120 --> 00:04:27.840 stronger higher surface activities  than the state of the art. Next please. 00:04:29.920 --> 00:04:35.920 So this is kind of cartoon image of how this  surface coating nano like it's gonna be like   00:04:35.920 --> 00:04:44.240 two to five nanometer thick coating, can  break the membranes of cell membranes of   00:04:44.240 --> 00:04:51.840 virus, and envelopes of virus and  cell membranes of viruses. Next. 00:04:54.720 --> 00:05:02.320 So we we did some proof of concept studies that  it shows that our coating can continue to kill   00:05:02.320 --> 00:05:09.840 the viruses and bacterias on the surface, and  it makes the surface very hydrophilic. And next. 00:05:11.200 --> 00:05:16.400 So this is also other tests that we based on the  AST [Antibiotic Susceptibility Testing] method   00:05:16.400 --> 00:05:22.480 Time-Kill Determination. You see that in  15 seconds, the Gemini coating can kill it   00:05:22.480 --> 00:05:29.440 completely in 15 seconds but 70 percent alcohol  still leaves some bacteria on the surface. Next. 00:05:31.840 --> 00:05:37.120 And 24 hour test, alcohol you know  once it evaporates, this is like porous   00:05:37.120 --> 00:05:42.800 textile products so it could still- some  residue of alcohol remains on the surface for   00:05:42.800 --> 00:05:47.920 five minutes so it's still effective. But  once it evaporate completely, it then can't   00:05:47.920 --> 00:05:55.920 kill anything on the surface but whereas I was  saying that coating can kill for 24 hours. Next. 00:05:57.680 --> 00:06:05.840 And you know it's even porous surface  you see that it's multiplies. Next. 00:06:06.400 --> 00:06:12.160 And this is non-porous surface such  as glass and plastic and metals   00:06:12.960 --> 00:06:17.760 that they use for door handles and  surface countertop and our coat   00:06:17.760 --> 00:06:25.040 evaporates in you know five to ten seconds  and it loses its effectiveness. And in next. 00:06:27.120 --> 00:06:35.520 And the comparison between ours and state of the  art which is single charged ammonium coating that   00:06:35.520 --> 00:06:43.120 uses in airport and airplane, they- these days we  use this coating so you are safe for 24 hours. But   00:06:43.120 --> 00:06:51.440 the problem is yeah it is there was coating that  can kill the germs and bacteria and viruses for   00:06:51.440 --> 00:06:56.880 24 hours, but how long does it take to kill it?  In five minute tests, it can't kill anything.   00:06:57.600 --> 00:07:03.040 Coronavirus- it only kills seventy percent of  coronavirus for five minutes. So yeah if you wait   00:07:03.040 --> 00:07:09.680 for an hours, it will kill the virus but in those  hours how many people will touch the surface? Like   00:07:10.240 --> 00:07:16.160 hundreds and thousands. Then you get all contact  transmission occurs. So compared to our new   00:07:17.040 --> 00:07:22.720 Gemini ammonium coated surface, it kills  everything in five- 100 percent in five   00:07:22.720 --> 00:07:29.360 seconds. We need this kind of technology unless  CDC provides much better you know instructions   00:07:29.360 --> 00:07:37.200 and interaction with how people will stop this  transmission contact transmission. So next. 00:07:39.200 --> 00:07:46.880 So currently we are on working with  some large distributor to distribute   00:07:46.880 --> 00:07:52.160 this technology and license out to some  companies, but we're still looking for   00:07:53.520 --> 00:07:57.840 other strategic partners also  university then we can do more-   00:07:58.480 --> 00:08:06.560 dive deep into you know into more test more  viruses and bacteria to see if there's any   00:08:06.560 --> 00:08:13.200 other area that we can we can help with this  coating technology and next please Helen. 00:08:14.720 --> 00:08:21.600 So the markets are huge and antimicrobial  catheters alone is 40 billion dollar market   00:08:21.600 --> 00:08:27.600 and disinfectant is like 10 billion,  5 billion, but it only goes up. So   00:08:27.600 --> 00:08:31.680 there are lots of market- a huge  market opportunity here. And next. 00:08:33.600 --> 00:08:37.840 But more importantly, we can save  lives with this and it's not just   00:08:37.840 --> 00:08:45.040 about SARS-CoV-2. It's more about  upcoming dangerous and contagious   00:08:48.080 --> 00:08:55.440 diseases- infectious diseases. We can  prevent those pandemics with this. Next. 00:08:56.320 --> 00:09:02.080 This is our members of our team  and there are actually one- the   00:09:03.280 --> 00:09:12.000 two people from Columbia University and working  with us so thank you and I'll take any questions.