Theses Doctoral

The Role of N6-methyladenosine RNA Methylation in the Regulation of Hematopoietic Stem Cells

Lee, Heather

Hematopoietic stem cells (HSCs) give rise to all blood cells and are characterized by their ability for life-long self-renewal and multilineage differentiation. HSC function is regulated by complex cell-intrinsic and -extrinsic pathways, but these regulatory mechanisms are not completely understood. Recent work has demonstrated that the epitranscriptional modification N6-methyladenosine (m6A) has important roles in the regulation of many physiologic and pathologic processes in various cell types, but it was previously unknown if and how m6A may regulate adult HSC function. In this work, I uncover the role for m6A in HSC regulation, both cell-intrinsically in regulating HSC differentiation and cell–extrinsically by regulating the formation the HSC bone marrow niche.


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More About This Work

Academic Units
Cellular, Molecular and Biomedical Studies
Thesis Advisors
Ding, Lei
Ph.D., Columbia University
Published Here
January 23, 2020