Academic Commons

Indoor air pollution exposure from use of indoor stoves and fireplaces in association with breast cancer: a case-control study

White, Alexandra J.; Teitelbaum, Susan L.; Stellman, Steven D.; Beyea, Jan; Steck, Susan E.; Mordukhovich, Irina; McCarty, Kathleen M.; Ahn, Jiyoung; Rossner Jr., Pavel; Santella, Regina M.; Gammon, Marilie D.

Background: Previous studies suggest that polycyclic aromatic hydrocarbons (PAHs) may adversely affect breast cancer risk. Indoor air pollution from use of indoor stoves and/or fireplaces is an important source of ambient PAH exposure. However, the association between indoor stove/fireplace use and breast cancer risk is unknown. We hypothesized that indoor stove/fireplace use in a Long Island, New York study population would be positively associated with breast cancer and differ by material burned, and the duration and timing of exposure. We also hypothesized that the association would vary by breast cancer subtype defined by p53 mutation status, and interact with glutathione S-transferases GSTM1, T1, A1 and P1 polymorphisms. Methods: Population-based, case-control resources (1,508 cases/1,556 controls) were used to conduct unconditional logistic regression to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI). Results: Breast cancer risk was increased among women reporting ever burning synthetic logs (which may also contain wood) in their homes (OR = 1.42, 95% CI 1.11, 1.84), but not for ever burning wood alone (OR = 0.93, 95% CI 0.77, 1.12). For synthetic log use, longer duration >7 years, older age at exposure (>20 years; OR = 1.65, 95% CI 1.02, 2.67) and 2 or more variants in GSTM1, T1, A1 or P1 (OR = 1.71, 95% CI 1.09, 2.69) were associated with increased risk. Conclusions: Burning wood or synthetic logs are both indoor PAH exposure sources; however, positive associations were only observed for burning synthetic logs, which was stronger for longer exposures, adult exposures, and those with multiple GST variant genotypes. Therefore, our results should be interpreted with care and require replication.

Files

  • thumnail for White_2014_StovesAndFireplaces_EnvironHealth__1_.pdf White_2014_StovesAndFireplaces_EnvironHealth__1_.pdf application/pdf 250 KB Download File

Also Published In

Title
Environmental Health
DOI
https://doi.org/10.1186/1476-069X-13-108

More About This Work

Academic Units
Epidemiology
Environmental Health Sciences
Publisher
BioMed Central
Published Here
June 14, 2015
Academic Commons provides global access to research and scholarship produced at Columbia University, Barnard College, Teachers College, Union Theological Seminary and Jewish Theological Seminary. Academic Commons is managed by the Columbia University Libraries.