Promises and challenges of personalized medicine to guide ARDS therapy

Wick, Katherine D.; McAuley, Daniel F.; Levitt, Joseph E.; Beitler, Jeremy R.; Annane, Djillali; Riviello, Elisabeth D.; Calfee, Carolyn S.; Matthay, Michael A.

Identifying new effective treatments for the acute respiratory distress syndrome (ARDS), including COVID-19 ARDS, remains a challenge. The field of ARDS investigation is moving increasingly toward innovative approaches such as the personalization of therapy to biological and clinical sub-phenotypes. Additionally, there is growing recognition of the importance of the global context to identify effective ARDS treatments. This review highlights emerging opportunities and continued challenges for personalizing therapy for ARDS, from identifying treatable traits to innovative clinical trial design and recognition of patient-level factors as the field of critical care investigation moves forward into the twenty-first century.


  • thumnail for 13054_2021_Article_3822.pdf 13054_2021_Article_3822.pdf application/pdf 415 KB Download File

Also Published In

More About This Work

Published Here
December 20, 2022


Acute respiratory distress syndrome, Acute lung injury, Personalized medicine, COVID-19, Clinical trials