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A Comparison of Cerebral Spect Abnormalities in Hiv-Positive Homosexual Men with and without Cognitive Impairment

Ned Sacktor; Ronald L. Van Heertum; George Dooneief; Jack M. Gorman; Alexander Khandji; Karen Marder; Ramy Nour; George Todak; Yaakov Stern; Richard Paul Mayeux

Title:
A Comparison of Cerebral Spect Abnormalities in Hiv-Positive Homosexual Men with and without Cognitive Impairment
Author(s):
Sacktor, Ned
Van Heertum, Ronald L.
Dooneief, George
Gorman, Jack M.
Khandji, Alexander
Marder, Karen
Nour, Ramy
Todak, George
Stern, Yaakov
Mayeux, Richard Paul
Date:
Type:
Articles
Department(s):
Neurology
Volume:
52
Persistent URL:
Book/Journal Title:
Archives of Neurology
Abstract:
Objective: To determine whether technetium Tc 99m exametazime (HMPAO) single-photon emission computed tomography (SPECT) can distinguish between human immunodeficiency virus (HIV)-positive homosexual men with normal neuropsychologic test results and HIV-positive homosexual men with abnormal neuropsychologic test results. Design: Neurologic, neuropsychologic, magnetic resonance imaging, and Tc 99m HMPAO SPECT examinations were performed on 10 HIV-positive homosexual men without cognitive impairment and five HIV-positive homosexual men with cognitive impairment. Patients: Human immunodeficiency virus—positive homosexual men from New York City were recruited for the study. Main Outcome Measures: Findings on SPECT scans were evaluated qualitatively for focal defects, heterogeneity of the cortical margin, white matter hypoperfusion, and decreased global cortical uptake. All SPECT focal defects were coregistered with magnetic resonance images; SPECT heterogeneity and global cortical uptake were also measured quantitatively. Results: Coregistration with magnetic resonance imaging revealed that 63% of the focal SPECT defects corresponded to brain gyri and 37% corresponded to sulci. There was no significant difference in the frequency of qualitative or quantitative SPECT abnormalities between HIV-positive homosexual men with and without cognitive impairment. However, after examining individual neuropsychologic test factors, impaired motor speed performance was associated with decreased quantitative global cerebral uptake. Conclusions: Qualitative SPECT abnormalities are not increased in frequency in HIV-positive homosexual men with global cognitive impairment compared with those in HIV-positive homosexual men without cognitive impairment. Impaired motor speed performance may be associated with decreased quantitative global cerebral uptake.
Subject(s):
Neurology
HIV-positive persons
Gay men
Cognition
Single-photon emission computed tomography
Publisher DOI:
https://doi.org/10.1001/archneur.1995.00540360048015
Item views
14
Metadata:
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Suggested Citation:
Ned Sacktor, Ronald L. Van Heertum, George Dooneief, Jack M. Gorman, Alexander Khandji, Karen Marder, Ramy Nour, George Todak, Yaakov Stern, Richard Paul Mayeux, , A Comparison of Cerebral Spect Abnormalities in Hiv-Positive Homosexual Men with and without Cognitive Impairment, Columbia University Academic Commons, .

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