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Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts

Max Werth; Kai M. Schmidt-Ott; Thomas Leete; Andong Qiu; Christian Hinze; Melanie Viltard; Neal Paragas; Carrie Shawber; Wenqiang Yu; Peter Lee; Xia Chen; Abby Sarkar; Weiyi Mu; Alexander Rittenberg; Chyuan-Sheng Lin; Jan K. Kitajewski; Qais Al-Awqati; Jonathon Barasch

Title:
Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts
Author(s):
Werth, Max
Schmidt-Ott, Kai M.
Leete, Thomas
Qiu, Andong
Hinze, Christian
Viltard, Melanie
Paragas, Neal
Shawber, Carrie
Yu, Wenqiang
Lee, Peter
Chen, Xia
Sarkar, Abby
Mu, Weiyi
Rittenberg, Alexander
Lin, Chyuan-Sheng
Kitajewski, Jan K.
Al-Awqati, Qais
Barasch, Jonathon
Date:
Type:
Articles
Department(s):
Medicine
Volume:
6
Persistent URL:
Book/Journal Title:
eLife
Abstract:
Although most nephron segments contain one type of epithelial cell, the collecting ducts consists of at least two: intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively. In adult kidneys, these cells are organized in rosettes suggesting functional interactions. Genetic studies in mouse revealed that transcription factor Tfcp2l1 coordinates IC and PC development. Tfcp2l1 induces the expression of IC specific genes, including specific H+-ATPase subunits and Jag1. Jag1 in turn, initiates Notch signaling in PCs but inhibits Notch signaling in ICs. Tfcp2l1 inactivation deletes ICs, whereas Jag1 inactivation results in the forfeiture of discrete IC and PC identities. Thus, Tfcp2l1 is a critical regulator of IC-PC patterning, acting cell-autonomously in ICs, and non-cell-autonomously in PCs. As a result, Tfcp2l1 regulates the diversification of cell types which is the central characteristic of 'salt and pepper' epithelia and distinguishes the collecting duct from all other nephron segments.
Subject(s):
Epithelial cells
Kidney tubules
Transcription factors
Nephrology
Publisher DOI:
https://doi.org/10.7554/eLife.24265
Item views
37
Metadata:
text | xml
Suggested Citation:
Max Werth, Kai M. Schmidt-Ott, Thomas Leete, Andong Qiu, Christian Hinze, Melanie Viltard, Neal Paragas, Carrie Shawber, Wenqiang Yu, Peter Lee, Xia Chen, Abby Sarkar, Weiyi Mu, Alexander Rittenberg, Chyuan-Sheng Lin, Jan K. Kitajewski, Qais Al-Awqati, Jonathon Barasch, , Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts, Columbia University Academic Commons, .

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