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Short-term exposure to PM2.5 and vanadium and changes in asthma gene DNA methylation and lung function decrements among urban children

Kyung Hwa Jung; David Z. Torrone; Stephanie Lovinsky-Desir; Matthew S. Perzanowski; Joshua B. Bautista; Jacqueline R. Jezioro; Lori A. Hoepner; Jamie Ross; Frederica P. Perera; Steven N. Chillrud; Rachel L. Miller

Title:
Short-term exposure to PM2.5 and vanadium and changes in asthma gene DNA methylation and lung function decrements among urban children
Author(s):
Jung, Kyung Hwa
Torrone, David Z.
Lovinsky-Desir, Stephanie
Perzanowski, Matthew S.
Bautista, Joshua B.
Jezioro, Jacqueline R.
Hoepner, Lori A.
Ross, Jamie
Perera, Frederica P.
Chillrud, Steven N.
Miller, Rachel L.
Date:
Type:
Articles
Department(s):
Medicine
Lamont-Doherty Earth Observatory
Pediatrics
Environmental Health Sciences
Volume:
18
Persistent URL:
Book/Journal Title:
Respiratory Research
Abstract:
BACKGROUND: Both short and long-term exposure to traffic-related air pollutants have been associated with asthma and reduced lung function. We hypothesized that short-term indoor exposure to fine particulate matter <2.5 μm (PM2.5) and vanadium (V) would be associated with altered buccal cell DNA methylation of targeted asthma genes and decreased lung function among urban children in a nested subcohort of African American and Dominican children. METHODS: Six day integrated levels of air pollutants were measured from children's homes (age 9-14; n = 163), repeated 6 months later (n = 98). Buccal samples were collected repeatedly during visits. CpG promoter loci of asthma genes (i.e., interleukin 4 (IL4), interferon gamma (IFNγ), inducible nitric oxide synthase (NOS2A), arginase 2 (ARG2)) were pyrosequenced and lung function was assessed. RESULTS: Exposure to V, but not PM2.5, was associated with lower DNA methylation of IL4 and IFNγ. In exploratory analyses, V levels were associated with lower methylation of the proinflammatory NOS2A-CpG+5099 among asthmatic overweight or obese children but not nonasthmatics. Short-term exposure to PM2.5, but not V, appeared associated with lower lung function (i.e., reduced z-scores for forced expiratory volume in one second (FEV1, FEV1/ forced vital capacity [FEV1/FVC] and forced expiratory flow at 25-75% of FVC [FEF25-75]). CONCLUSIONS: Exposure to V was associated with altered DNA methylation of allergic and proinflammatory asthma genes implicated in air pollution related asthma. However, short-term exposure to PM2.5, but not V, appeared associated with decrements in lung function among urban children.
Subject(s):
Vanadium
DNA--Methylation
Lungs
Asthma in children
Publisher DOI:
https://doi.org/10.1186/s12931-017-0550-9
Item views
81
Metadata:
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Suggested Citation:
Kyung Hwa Jung, David Z. Torrone, Stephanie Lovinsky-Desir, Matthew S. Perzanowski, Joshua B. Bautista, Jacqueline R. Jezioro, Lori A. Hoepner, Jamie Ross, Frederica P. Perera, Steven N. Chillrud, Rachel L. Miller, , Short-term exposure to PM2.5 and vanadium and changes in asthma gene DNA methylation and lung function decrements among urban children, Columbia University Academic Commons, .

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