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A transcriptomic atlas of aged human microglia

Marta Olah; Ellis Patrick; Alexandra-Chloe Villani; Jishu Xu; Charles C. White; Katie J. Ryan; Paul Piehowski; Alifiya Kapasi; Parham Nejad; Maria Cimpean; Sarah Connor; Christina J. Yung; Michael Frangieh; Allison McHenry; Wassim Elyaman; Vlad Petyuk; Julie A. Schneider; David A. Bennett; Philip Lawrence De Jager; Elizabeth Bradshaw

Title:
A transcriptomic atlas of aged human microglia
Author(s):
Olah, Marta
Patrick, Ellis
Villani, Alexandra-Chloe
Xu, Jishu
White, Charles C.
Ryan, Katie J.
Piehowski, Paul
Kapasi, Alifiya
Nejad, Parham
Cimpean, Maria
Connor, Sarah
Yung, Christina J.
Frangieh, Michael
McHenry, Allison
Elyaman, Wassim
Petyuk, Vlad
Schneider, Julie A.
Bennett, David A.
De Jager, Philip Lawrence
Bradshaw, Elizabeth
Date:
Type:
Articles
Department(s):
Neurology
Taub Institute
Volume:
9
Persistent URL:
Book/Journal Title:
Nature Communications
Abstract:
With a rapidly aging global human population, finding a cure for late onset neurodegenerative diseases has become an urgent enterprise. However, these efforts are hindered by the lack of understanding of what constitutes the phenotype of aged human microglia—the cell type that has been strongly implicated by genetic studies in the pathogenesis of age-related neurodegenerative disease. Here, we establish the set of genes that is preferentially expressed by microglia in the aged human brain. This HuMi_Aged gene set captures a unique phenotype, which we confirm at the protein level. Furthermore, we find this gene set to be enriched in susceptibility genes for Alzheimer’s disease and multiple sclerosis, to be increased with advancing age, and to be reduced by the protective APOEε2 haplotype. APOEε4 has no effect. These findings confirm the existence of an aging-related microglial phenotype in the aged human brain and its involvement in the pathological processes associated with brain aging.
Subject(s):
Microglia
Neuroimmunology
Nervous system--Degeneration
Brain--Aging
Publisher DOI:
https://doi.org/10.1038/s41467-018-02926-5
Item views
36
Metadata:
text | xml
Suggested Citation:
Marta Olah, Ellis Patrick, Alexandra-Chloe Villani, Jishu Xu, Charles C. White, Katie J. Ryan, Paul Piehowski, Alifiya Kapasi, Parham Nejad, Maria Cimpean, Sarah Connor, Christina J. Yung, Michael Frangieh, Allison McHenry, Wassim Elyaman, Vlad Petyuk, Julie A. Schneider, David A. Bennett, Philip Lawrence De Jager, Elizabeth Bradshaw, , A transcriptomic atlas of aged human microglia, Columbia University Academic Commons, .

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