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A Comparison Study of Cognitive and Neuropsychiatric Features of Essential Tremor and Parkinson’s Disease

Verónica Puertas-Martín; Sara Fernández-Guinea; Alberto Villarejo-Galende; Elan D. Louis; Juan Pablo Romero; Julián Benito-León

Title:
A Comparison Study of Cognitive and Neuropsychiatric Features of Essential Tremor and Parkinson’s Disease
Author(s):
Puertas-Martín, Verónica
Fernández-Guinea, Sara
Villarejo-Galende, Alberto
Louis, Elan D.
Romero, Juan Pablo
Benito-León, Julián
Date:
Type:
Articles
Department(s):
Center for Parkinson's Disease and Other Movement Disorders
Volume:
6
Persistent URL:
Book/Journal Title:
Tremor and Other Hyperkinetic Movements
Publisher:
The Center for Digital Research and Scholarship
Abstract:
Background: Essential tremor (ET) and Parkinson’s disease (PD) are two of the most common movement disorders. Leaving aside their motor features, these two conditions share several non-motor features, including cognitive dysfunction and personality changes. However, there are few data comparing the cognitive and personality profiles of ET with PD. Here we compare the cognitive and personality profiles of the two diseases. Methods: Thirty-two consecutive non-demented ET patients (13 females and 19 males) (67.7±9.8 years), 32 non-demented PD patients (13 females and 19 males) (67.7±9.5 years), and 32 healthy matched controls (14 females and 18 males) (67.9±10.1 years) underwent a neuropsychological test battery, including a global cognitive assessment and tests of attention, executive function, memory, language, and visuospatial function, as well as the Personality Assessment Inventory. Multivariable linear regression analyses were performed, adjusted for age, sex, years of education, medications that potentially affect cognitive function, number of medications, and the 17-item Hamilton Depression Rating Scale Total Score. Results: Neuropsychological scores were similar in PD and ET patients, but patients with disease performed more poorly than control subjects in cognitive tasks such as attention, executive function, memory, and naming. Discussion: ET and PD exhibited similar deficits in specific aspects of neuropsychological functioning, particularly those thought to rely on the integrity of the prefrontal cortex, and this suggests involvement of frontocerebellar circuits. These findings further challenge the traditional view of ET as a benign and monosymptomatic disorder.
Subject(s):
Tremor
Parkinson's disease
Neuropsychology
Movement disorders
Neurosciences
Medicine
Publisher DOI:
https://doi.org/10.7916/D86H4HRN
Item views
111
Metadata:
text | xml
Suggested Citation:
Verónica Puertas-Martín, Sara Fernández-Guinea, Alberto Villarejo-Galende, Elan D. Louis, Juan Pablo Romero, Julián Benito-León, , A Comparison Study of Cognitive and Neuropsychiatric Features of Essential Tremor and Parkinson’s Disease, Columbia University Academic Commons, .

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