HomeHome

Pediatric Anesthesia and Neurodevelopmental Impairments: A Bayesian Meta-analysis

Charles J. DiMaggio; Lena S. Y. Sun; Caleb H. Ing; Guohua Li

Title:
Pediatric Anesthesia and Neurodevelopmental Impairments: A Bayesian Meta-analysis
Author(s):
DiMaggio, Charles J.
Sun, Lena S. Y.
Ing, Caleb H.
Li, Guohua
Date:
Type:
Articles
Department(s):
Epidemiology
Anesthesiology
Volume:
24
Persistent URL:
Book/Journal Title:
Journal of Neurosurgical Anesthesiology
Publisher:
Lippincott, Williams and Wilkins
Abstract:
Experimental evidence of anesthesia-induced neurotoxicity has caused serious concern about the long-term effect of commonly used volatile anesthetic agents on young children. Several observational studies based on existing data have been conducted to address this concern with inconsistent results. We conducted a meta-analysis to synthesize the epidemiologic evidence on the association of anesthesia/surgery with neurodevelopmental outcomes in children. Using Bayesian meta-analytic approaches, we estimated the synthesized odds ratios (OR) and 95% credible interval (CrI) as well as the predictive distribution of a future study given the synthesized evidence. Data on 7 unadjusted and 6 adjusted measures of association were abstracted from 7 studies. The synthesized OR based on the 7 unadjusted measures for the association of anesthesia/surgery with an adverse behavioral or developmental outcome was 1.9 (95% CrI, 1.2-3.0). The most likely unadjusted OR from a future study was estimated to be 2.2 (95% CrI, 0.6-6.1). The synthesized OR based on the 6 adjusted measures for the association of anesthesia/surgery with an adverse behavioral or developmental outcome was 1.4 (95% CrI, 0.9-2.2). The most likely adjusted OR from a future study was estimated to be 1.5 (95% CrI, 0.5-4.0). We conclude that existent epidemiologic evidence suggests a modestly elevated risk of adverse behavioral or developmental outcomes in children who were exposed to anesthesia/surgery during early childhood. The evidence, however, is considerably uncertain.
Subject(s):
Neurotoxicology
Anesthesia
Pediatric anesthesia--Complications
Pediatric anesthesia
Anesthesiology
Epidemiology
Neurosciences
Publisher DOI:
https://doi.org/10.1097/ANA.0b013e31826a038d
Item views
74
Metadata:
text | xml
Suggested Citation:
Charles J. DiMaggio, Lena S. Y. Sun, Caleb H. Ing, Guohua Li, , Pediatric Anesthesia and Neurodevelopmental Impairments: A Bayesian Meta-analysis, Columbia University Academic Commons, .

Columbia University Libraries | Policies | FAQ