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Occurrence of Dysphagia Following Botulinum Toxin Injection in Parkinsonism-related Cervical Dystonia: A Retrospective Study

Addie Patterson; Leonardo Almeida; Christopher W. Hess; Daniel Martinez-Ramirez; Michael S. Okun; Ramon L. Rodriguez; Valerie Rundle-Gonzalez; Aparna Wagle Shukla; Irene A. Malaty

Title:
Occurrence of Dysphagia Following Botulinum Toxin Injection in Parkinsonism-related Cervical Dystonia: A Retrospective Study
Author(s):
Patterson, Addie
Almeida, Leonardo
Hess, Christopher W.
Martinez-Ramirez, Daniel
Okun, Michael S.
Rodriguez, Ramon L.
Rundle-Gonzalez, Valerie
Shukla, Aparna Wagle
Malaty, Irene A.
Date:
Type:
Articles
Department(s):
Center for Parkinson's Disease and Other Movement Disorders
Volume:
6
Persistent URL:
Book/Journal Title:
Tremor and Other Hyperkinetic Movements
Abstract:
Background: The aim was to compare the occurrence of post-injection dysphagia in parkinsonism-related cervical dystonia (PRCD) versus cervical dystonia (CD) of other etiologies (non-PRCD). A secondary objective was to explore potential clinical differences between PRCD and non-PRCD and their respective responses to botulinum toxin (BoNT). Methods: A cross-sectional chart review was carried out of patients treated for CD with Onabotulinumtoxin A at the University of Florida. We collected demographic information, dose of BoNT injected, patient-reported presence of dysphagia as a side effect, patient-perceived duration of benefit and efficacy according to the Clinical Global Impression Scale (CGIS). Results: Of the 144 patients included, 24 patients were diagnosed with PRCD and 120 were diagnosed as non-PRCD. Data analysis showed no significant differences in number of weeks of benefit from BoNT (PRCD 9.1±3.7 versus non-PRCD 9.4±3.7 weeks, p = 0.830), BoNT dosage (PRCD 235.0±95.6 versus non-PRCD 263.7±101.3 units, p = 0.181), median CGIS score (median = 2 or “much improved” for both groups, p = 0.88), or the presence of dysphagia after BoNT (PRCD 17% versus non-PRCD 19 %, p = 0.753, n = 132). In a subgroup analysis of the non-PRCD group, patients who experienced dysphagia were older than those who did not (63.9±8.9 years versus 58.1±14.4 years, p = 0.02). Discussion: Despite an increased baseline risk of dysphagia in patients with PRCD, BoNT appears to be equally safe and equally beneficial in PRCD and non-PRCD patients.
Subject(s):
Medicine
Neurosciences
Movement disorders
Parkinson's disease--Treatment
Botulinum toxin
Dystonia
Cervical vertebrae--Diseases
Deglutition disorders
Publisher DOI:
http://dx.doi.org/10.7916/D8GB24C5
Item views
120
Metadata:
text | xml
Suggested Citation:
Addie Patterson, Leonardo Almeida, Christopher W. Hess, Daniel Martinez-Ramirez, Michael S. Okun, Ramon L. Rodriguez, Valerie Rundle-Gonzalez, Aparna Wagle Shukla, Irene A. Malaty, , Occurrence of Dysphagia Following Botulinum Toxin Injection in Parkinsonism-related Cervical Dystonia: A Retrospective Study, Columbia University Academic Commons, .

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