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Lipoprotein-Associated Phospholipase A2 Is Associated with Atherosclerotic Stroke Risk: The Northern Manhattan Study

Mira Katan; Yeseon P. Moon; Myunghee C. Paik; Robert L. Wolfert; Ralph L. Sacco; Mitchell S. Elkind

Title:
Lipoprotein-Associated Phospholipase A2 Is Associated with Atherosclerotic Stroke Risk: The Northern Manhattan Study
Author(s):
Katan, Mira
Moon, Yeseon P.
Paik, Myunghee C.
Wolfert, Robert L.
Sacco, Ralph L.
Elkind, Mitchell S.
Date:
Type:
Articles
Department(s):
Neurology
Volume:
9
Persistent URL:
Book/Journal Title:
PLOS ONE
Abstract:
Background Lipoprotein-associated phospholipase A2 (LpPLA2) levels are associated with stroke, though whether this extends to all populations and stroke subtypes is unknown. Methods Serum samples from stroke-free community participants in the Northern Manhattan Study were assayed for LpPLA2 mass and activity. Participants were followed annually for stroke. Cox-proportional-hazard models were fitted to estimate hazard-ratios and 95% confidence intervals (HR, 95% CI) for the association of LpPLA2 levels with ischemic stroke (IS), after adjusting for demographic and medical risk factors. Results Serum samples were available in 1946 participants, of whom 151 (7.8%) experienced a first IS during median follow-up 11 years. Mean age was 69 (SD 10), 35.6% were men, 20% non-Hispanic Whites, 22% non-Hispanic Blacks, and 55% Hispanics. LpPLA2 mass and activity levels were not associated with overall IS risk. LpPLA2 mass but not activity levels were associated with strokes due to large artery atherosclerosis (LAA; adjusted HR per SD 1.55, 95% CI 1.17–2.04). There was a dose-response relationship with LAA (compared to first quartile, 2nd quartile HR = 1.43, 95% CI 0.23–8.64; 3rd quartile HR = 4.47, 95% CI 0.93–21.54; 4th quartile HR = 5.07, 95% CI 1.07–24.06). The associations between LpPLA2-mass and LAA-stroke risk differed by race-ethnicity (p = 0.01); LpPLA2-mass was associated with increased risk of LAA among non-Hispanic Whites (adjusted HR per SD 1.44, 95% CI 0.98–2.11), but not other race-ethnic groups. Conclusion LpPLA2-mass levels were associated with risk of atherosclerotic stroke among non-Hispanic White participants, but not in other race-ethnic groups in the cohort. Further study is needed to confirm these race-ethnic differences and the reasons for them.
Subject(s):
Phospholipases
Atherosclerosis--Risk factors
Cerebrovascular disease
Biochemistry
Publisher DOI:
https://doi.org/10.1371/journal.pone.0083393
Item views
91
Metadata:
text | xml
Suggested Citation:
Mira Katan, Yeseon P. Moon, Myunghee C. Paik, Robert L. Wolfert, Ralph L. Sacco, Mitchell S. Elkind, , Lipoprotein-Associated Phospholipase A2 Is Associated with Atherosclerotic Stroke Risk: The Northern Manhattan Study, Columbia University Academic Commons, .

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