HomeHome

Opposing Effects of α2- and β-Adrenergic Receptor Stimulation on Quiescent Neural Precursor Cell Activity and Adult Hippocampal Neurogenesis

Dhanisha J. Jhaveri; Ishira Nanavaty; Boris W. Prosper; Swanand Marathe; Basma F. A. Husain; Steven G. Kernie; Perry F. Bartlett; Vidita A. Vaidya

Title:
Opposing Effects of α2- and β-Adrenergic Receptor Stimulation on Quiescent Neural Precursor Cell Activity and Adult Hippocampal Neurogenesis
Author(s):
Jhaveri, Dhanisha J.
Nanavaty, Ishira
Prosper, Boris W.
Marathe, Swanand
Husain, Basma F. A.
Kernie, Steven G.
Bartlett, Perry F.
Vaidya, Vidita A.
Date:
Type:
Articles
Department(s):
Pediatrics
Volume:
9
Persistent URL:
Book/Journal Title:
PLOS ONE
Publisher:
Public Library of Science
Abstract:
Norepinephrine regulates latent neural stem cell activity and adult hippocampal neurogenesis, and has an important role in modulating hippocampal functions such as learning, memory and mood. Adult hippocampal neurogenesis is a multi-stage process, spanning from the activation and proliferation of hippocampal stem cells, to their differentiation into neurons. However, the stage-specific effects of noradrenergic receptors in regulating adult hippocampal neurogenesis remain poorly understood. In this study, we used transgenic Nestin-GFP mice and neurosphere assays to show that modulation of α2- and β-adrenergic receptor activity directly affects Nestin-GFP/GFAP-positive precursor cell population albeit in an opposing fashion. While selective stimulation of α2-adrenergic receptors decreases precursor cell activation, proliferation and immature neuron number, stimulation of β-adrenergic receptors activates the quiescent precursor pool and enhances their proliferation in the adult hippocampus. Furthermore, our data indicate no major role for α1-adrenergic receptors, as we did not observe any change in either the activation and proliferation of hippocampal precursors following selective stimulation or blockade of α1-adrenergic receptors. Taken together, our data suggest that under physiological as well as under conditions that lead to enhanced norepinephrine release, the balance between α2- and β-adrenergic receptor activity regulates precursor cell activity and hippocampal neurogenesis.
Subject(s):
Alpha adrenoceptors
Hippocampus (Brain)--Growth
Developmental neurobiology
Beta adrenoceptors
Neurosciences
Cytology
Publisher DOI:
https://doi.org/10.1371/journal.pone.0098736
Item views
129
Metadata:
text | xml
Suggested Citation:
Dhanisha J. Jhaveri, Ishira Nanavaty, Boris W. Prosper, Swanand Marathe, Basma F. A. Husain, Steven G. Kernie, Perry F. Bartlett, Vidita A. Vaidya, , Opposing Effects of α2- and β-Adrenergic Receptor Stimulation on Quiescent Neural Precursor Cell Activity and Adult Hippocampal Neurogenesis, Columbia University Academic Commons, .

Columbia University Libraries | Policies | FAQ