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Causal Structure of Brain Physiology after Brain Injury from Subarachnoid Hemorrhage

Jan Claassen; Shah Atiqur Rahman; Yuxiao Huang; Hans-Peter Frey; J. Michael Schmidt; David J. Albers; Maria Cristina Falo; Soojin Park; Sachin Agarwal; E. Sander Connolly Jr.; Samantha Kleinberg

Title:
Causal Structure of Brain Physiology after Brain Injury from Subarachnoid Hemorrhage
Author(s):
Claassen, Jan
Rahman, Shah Atiqur
Huang, Yuxiao
Frey, Hans-Peter
Schmidt, J. Michael
Albers, David J.
Falo, Maria Cristina
Park, Soojin
Agarwal, Sachin
Connolly Jr., E. Sander
Kleinberg, Samantha
Date:
Type:
Articles
Department(s):
Biomedical Informatics
Neurology
Neurological Surgery
Volume:
11
Persistent URL:
Book/Journal Title:
PLoS ONE
Publisher:
Public Library of Science
Abstract:
High frequency physiologic data are routinely generated for intensive care patients. While massive amounts of data make it difficult for clinicians to extract meaningful signals, these data could provide insight into the state of critically ill patients and guide interventions. We develop uniquely customized computational methods to uncover the causal structure within systemic and brain physiologic measures recorded in a neurological intensive care unit after subarachnoid hemorrhage. While the data have many missing values, poor signal-to-noise ratio, and are composed from a heterogeneous patient population, our advanced imputation and causal inference techniques enable physiologic models to be learned for individuals. Our analyses confirm that complex physiologic relationships including demand and supply of oxygen underlie brain oxygen measurements and that mechanisms for brain swelling early after injury may differ from those that develop in a delayed fashion. These inference methods will enable wider use of ICU data to understand patient physiology.
Subject(s):
Brain damage--Patients
Brain--Physiology
Intensive care units--Data processing
Subarachnoid hemorrhage
Neurosciences
Physiology
Medical sciences
Publisher DOI:
https://doi.org/10.1371/journal.pone.0149878
Item views
363
Metadata:
text | xml
Suggested Citation:
Jan Claassen, Shah Atiqur Rahman, Yuxiao Huang, Hans-Peter Frey, J. Michael Schmidt, David J. Albers, Maria Cristina Falo, Soojin Park, Sachin Agarwal, E. Sander Connolly Jr., Samantha Kleinberg, , Causal Structure of Brain Physiology after Brain Injury from Subarachnoid Hemorrhage, Columbia University Academic Commons, .

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