HomeHome

Mediterranean Diet, Inflammatory and Metabolic Biomarkers, and Risk of Alzheimer's Disease

Yian Gu; Jose A. Luchsinger; Yaakov Stern; Nikolaos Scarmeas

Title:
Mediterranean Diet, Inflammatory and Metabolic Biomarkers, and Risk of Alzheimer's Disease
Author(s):
Gu, Yian
Luchsinger, Jose A.
Stern, Yaakov
Scarmeas, Nikolaos
Date:
Type:
Articles
Department(s):
Taub Institute
Volume:
22
Persistent URL:
Book/Journal Title:
Journal of Alzheimer’s Disease
Publisher:
IOS Press
Abstract:
We aimed to investigate the association between adherence to the Mediterranean diet (MeDi) and Alzheimer's disease (AD) risk in a prospective study. Specifically, we analyzed reduced inflammation and improved metabolic profile as a potential medium through which the MeDi reduced the risk of AD. During a 4-year follow-up, 118 incident AD cases were identified among the 1219 non-demented elderly (age ⩾ 65) subjects who provided dietary information and blood samples at baseline. We used high-sensitivity C-reactive protein (hsCRP) as an index of systemic inflammation, and fasting insulin and adiponectin as indexes of metabolic profile. We investigated whether there was a change in the association between MeDi and incident AD risk when the biomarkers were introduced into multivariable adjusted COX models. Better adherence to MeDi was associated with lower level of hsCRP (p =0.003), but not fasting insulin or adiponectin. Better adherence to MeDi was significantly associated with lower risk for AD: compared to those in the lowest tertile of MeDi, subjects in the highest tertile had a 34% less risk of developing AD (p-for-trend =0.04). Introduction of the hsCRP, fasting insulin, adiponectin, or combinations of them into the COX model did not change the magnitude of the association between MeDi and incident AD. Ultimately, the favorable association between better adherence to MeDi and lower risk of AD did not seem to be mediated by hsCRP, fasting insulin, or adiponectin. Other aspects of inflammatory and metabolic pathways not captured by these biomarkers, or non-inflammatory or non-metabolic pathways, may be relevant to the MeDi-AD association.
Subject(s):
Dementia
Metabolism
Mild cognitive impairment
Alzheimer's disease
Inflammation
Older people--Mental health
Cooking, Mediterranean
Epidemiology
Nutrition
Mental health
Gerontology
Publisher DOI:
https://doi.org/10.3233/JAD-2010-100897
Item views
91
Metadata:
text | xml
Suggested Citation:
Yian Gu, Jose A. Luchsinger, Yaakov Stern, Nikolaos Scarmeas, , Mediterranean Diet, Inflammatory and Metabolic Biomarkers, and Risk of Alzheimer's Disease, Columbia University Academic Commons, .

Columbia University Libraries | Policies | FAQ