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Brain tissue volume changes following weight gain in adults with anorexia nervosa

Christina A. Roberto; Laurel Mayer; Adam M. Brickman; Anna Barnes; Jordan Scott Muraskin; Lok-Kin Yeung; Jason Steffener; Melissa Sy; Joy Hirsch; Yaakov Stern; B. Timothy Walsh

Title:
Brain tissue volume changes following weight gain in adults with anorexia nervosa
Author(s):
Roberto, Christina A.
Mayer, Laurel
Brickman, Adam M.
Barnes, Anna
Muraskin, Jordan Scott
Yeung, Lok-Kin
Steffener, Jason
Sy, Melissa
Hirsch, Joy
Stern, Yaakov
Walsh, B. Timothy
Date:
Type:
Articles
Department(s):
Taub Institute
Volume:
44
Persistent URL:
Book/Journal Title:
International Journal of Eating Disorders
Publisher:
Wiley
Abstract:
Objective: To measure brain volume deficits among underweight patients with anorexia nervosa (AN) compared to control participants and evaluate the reversibility of these deficits with short-term weight restoration. Method: Brain volume changes in gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) were examined in 32 adult women with AN and compared to 21, age and body mass index-range matched control women. Results: Patients with AN had a significant increase in GM (p = .006, η2 = 0.14) and WM volume (p = .001, η2 = 0.19) following weight restoration. Patients on average had lower levels of GM at low weight (647.63 ± 62.07 ml) compared to controls (679.93 ± 53.31 ml), which increased with weight restoration (662.64 ± 69.71 ml), but did not fully normalize. Discussion: This study suggests that underweight adult patients with AN have reduced GM and WM volumes that increase with short-term weight restoration.
Subject(s):
Anorexia nervosa--Physiological aspects
Starvation
Weight gain
Brain--Growth
Brain--Abnormalities
Anorexia nervosa
Mental health
Neurosciences
Publisher DOI:
https://doi.org/10.1002/eat.20840
Item views
98
Metadata:
text | xml
Suggested Citation:
Christina A. Roberto, Laurel Mayer, Adam M. Brickman, Anna Barnes, Jordan Scott Muraskin, Lok-Kin Yeung, Jason Steffener, Melissa Sy, Joy Hirsch, Yaakov Stern, B. Timothy Walsh, , Brain tissue volume changes following weight gain in adults with anorexia nervosa, Columbia University Academic Commons, .

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