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Transcription activity hot spot, is it real or an artifact?

Shuang Wang; Tian Zheng; Yuanjia Wang

Title:
Transcription activity hot spot, is it real or an artifact?
Author(s):
Wang, Shuang
Zheng, Tian
Wang, Yuanjia
Date:
Type:
Articles
Department(s):
Biostatistics
Statistics
Volume:
1
Persistent URL:
Book/Journal Title:
BMC Proceedings
Publisher:
BioMed Central
Abstract:
Transcription activity 'hot spots', defined as chromosome regions that contain more expression quantitative trait loci than would have been expected by chance, have been frequently detected both in humans and in model organisms. It has been common to consider the existence of hot spots as evidence for master regulation of gene expression. However, hot spots could also simply be due to highly correlated gene expressions or linkage disequilibrium and do not truly represent master regulators. A recent simulation study using real human gene expression data but simulated random single-nucleotide polymorphism genotypes showed patterns of clustering of expression quantitative trait loci that resemble those in actual studies [Perez-Enciso: Genetics 2004, 166: 547–554.]. In this study, to assess the credibility of transcription activity hot spots, we conducted genetic analyses on gene expressions provided by Genetic Analysis Workshop 15 Problem 1.
Subject(s):
Genetics
Biometry
Item views
135
Metadata:
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Suggested Citation:
Shuang Wang, Tian Zheng, Yuanjia Wang, , Transcription activity hot spot, is it real or an artifact?, Columbia University Academic Commons, .

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