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Fat in hearts: Uptake, storage, and turnover

Chad Trent

Title:
Fat in hearts: Uptake, storage, and turnover
Author(s):
Trent, Chad
Thesis Advisor(s):
Goldberg, Ira Jay
Date:
Type:
Theses
Degree:
Ph.D., Columbia University
Department(s):
Nutritional and Metabolic Biology
Persistent URL:
Abstract:
The heart is one of the most energy demanding organs and is metabolically flexible to meet those demands. A major fraction of the hearts energy is derived from the uptake of circulating lipids; this dissertation reviews general pathways of lipid metabolism and then discusses how the heart obtains lipids and how these lipids are processed once inside the heart. Furthermore, derangements in lipid uptake and processing that are associated or causative of cardiac dysfunction are discussed. A new finding describes how the mouse heart requires lipoprotein lipase derived fatty acids for intracellular lipid droplets formation. Finally, the implications of these findings and future studies are described.
Subject(s):
Nutrition
Item views
345
Metadata:
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Suggested Citation:
Chad Trent, , Fat in hearts: Uptake, storage, and turnover, Columbia University Academic Commons, .

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