Carranza Michael A. author Snyder Madeline R. author Elble Rodger J. author Boutzoukas Angelique E. author Zesiewicz Theresa A. author Columbia University. Center for Parkinson's Disease and Other Movement Disorders originator text Articles 2012 English Essential tremor (ET) is one of the most common tremor disorders in the world. Despite this, only two medications have received Level A recommendations from the American Academy of Neurology to treat it (primidone and propranolol). Even though these medications provide relief to a large group of ET patients, up to 50% of patients are non-responders. Additional medications to treat ET are needed. This review discusses some of the methodological issues that should be addressed for quality clinical drug development in ET. Neurosciences 2 1 4 2012 2160-8288 http://hdl.handle.net/10022/AC:P:14473 NNC NNC 2012-08-21 15:53:20 -0400 2012-08-21 15:56:49 -0400 8493 eng