Cohen Matthew A. author Columbia University. Obstetrics and Gynecology Lindheim Steven R. author Columbia University. Obstetrics and Gynecology Sauer Mark V. author Columbia University. Obstetrics and Gynecology Columbia University. Obstetrics and Gynecology originator text Articles 1999 English Several reports suggest increasing age in oocyte donors decreases the chances of in-vitro fertilization (IVF) success, while others describe no effect. The published data concerning gravidity and parity are similarly conflicting. To further address these questions, we retrospectively studied 445 consecutive donor IVF cycles at two large university-based IVF practices. Donor cycles were analysed for the number of oocytes retrieved, gravidity, parity, and age of the donor, and pregnancy outcome in recipients. The previous gravidity and parity of the donor were not associated with successful pregnancy in recipients. The number of oocytes retrieved was positively correlated with pregnancy. However, after adjusting for donor age, neither prior fertility nor the number of oocytes retrieved were significant predictors. In contrast, the donor's age was highly associated with recipient success. We conclude that the age of the oocyte donor is a significant predictor of pregnancy success and should be a major factor in selecting prospective candidates. The gravidity and parity of the donor are insignificant predictors, as are the total number of oocytes retrieved at the time of oocyte harvest. Obstetrics and gynecology 14 11 2755 2758 1999-11 http://dx.doi.org/10.1093/humrep/14.11.2755 http://hdl.handle.net/10022/AC:P:14416 NNC NNC 2012-08-16 16:08:42 -0400 2012-08-16 16:14:11 -0400 8436 eng