Liu Sheena Xin author Kender John R. author Columbia University. Computer Science Imielinska Celina Z. author Columbia University. Radiation Oncology Laine Andrew F. author Columbia University. Biomedical Engineering Columbia University. Radiology Columbia University. Radiation Oncology originator text Articles 2011 English A novel method to automatically compute the symmetry plane and to correct the 3D orientation of neuro-images is presented. In acquisition of neuroimaging scans, the lack of perfect alignment of a patient's head makes it challenging to evaluate brain images. By deploying a shape-based criterion, the symmetry plane is defined as a plane that best matches external surface points on one side of the head, with their counterparts on the other side. In our method, the head volume is represented as a re-parameterized surface point cloud, where each location is parameterized by its elevation (latitude), azimuth (longitude), and radius. The search for the best matching surfaces is implemented in a multi-resolution paradigm, and the computation time is significantly decreased. The algorithm was quantitatively evaluated using in both simulated data and in real T1, T2, Flair magnetic resonance patient images. This algorithm is found to be fast (< 10s per MR volume), robust and accurate (< .6 degree of Mean Angular Error), invariant to the acquisition noise, slice thickness, bias field, and pathological asymmetries. Medical imaging and radiology Neurosciences 21 2 e15 e33 2011-04 http://dx.doi.org/10.1111/j.1552-6569.2011.00576.x http://hdl.handle.net/10022/AC:P:14354 NNC NNC 2012-08-13 13:25:07 -0400 2012-08-13 13:35:12 -0400 8373 eng