Home

In vitro characterization of cardiac radiofrequency ablation lesions using optical coherence tomography

Christine P. Fleming; Kara J. Quan; Hui Wang; Guy Amit; Andrew M. Rollins

Title:
In vitro characterization of cardiac radiofrequency ablation lesions using optical coherence tomography
Author(s):
Fleming, Christine P.
Quan, Kara J.
Wang, Hui
Amit, Guy
Rollins, Andrew M.
Date:
Type:
Articles
Department:
Electrical Engineering
Volume:
18
Permanent URL:
Book/Journal Title:
Optics Express
Abstract:
Currently, cardiac radiofrequency ablation (RFA) is guided by indirect signals. We demonstrate optical coherence tomography (OCT) characterization of RFA lesions within swine ventricular wedges. Untreated tissue exhibited a consistent birefringence artifact within OCT images due to the organized myocardium, which was not present in treated tissue. Birefringence artifacts were detected by filtering with a Laplacian of Gaussian (LoG) to quantify gradient strength. The gradient strength distinguished RFA lesions from untreated sites (p=5.93×10-15) with a sensitivity and specificity of 94.5% and 86.7% respectively. This study demonstrates the potential of OCT for monitoring cardiac RFA, confirming lesion formation and providing feedback to avoid complications.
Subject(s):
Optics
Publisher DOI:
http://dx.doi.org/10.1364/OE.18.003079
Item views:
213
Metadata:
text | xml

In Partnership with the Center for Digital Research and Scholarship at Columbia University Libraries/Information Services | Terms of Use