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In vitro characterization of cardiac radiofrequency ablation lesions using optical coherence tomography

Christine P. Fleming; Kara J. Quan; Hui Wang; Guy Amit; Andrew M. Rollins

Title:
In vitro characterization of cardiac radiofrequency ablation lesions using optical coherence tomography
Author(s):
Fleming, Christine P.
Quan, Kara J.
Wang, Hui
Amit, Guy
Rollins, Andrew M.
Date:
Type:
Articles
Department:
Electrical Engineering
Volume:
18
Permanent URL:
Book/Journal Title:
Optics Express
Abstract:
Currently, cardiac radiofrequency ablation (RFA) is guided by indirect signals. We demonstrate optical coherence tomography (OCT) characterization of RFA lesions within swine ventricular wedges. Untreated tissue exhibited a consistent birefringence artifact within OCT images due to the organized myocardium, which was not present in treated tissue. Birefringence artifacts were detected by filtering with a Laplacian of Gaussian (LoG) to quantify gradient strength. The gradient strength distinguished RFA lesions from untreated sites (p=5.93×10-15) with a sensitivity and specificity of 94.5% and 86.7% respectively. This study demonstrates the potential of OCT for monitoring cardiac RFA, confirming lesion formation and providing feedback to avoid complications.
Subject(s):
Optics
Publisher DOI:
http://dx.doi.org/10.1364/OE.18.003079
Item views:
235
Metadata:
text | xml
Suggested Citation:
Christine P. Fleming, Kara J. Quan, Hui Wang, Guy Amit, Andrew M. Rollins, 2010, In vitro characterization of cardiac radiofrequency ablation lesions using optical coherence tomography, Columbia University Academic Commons, http://hdl.handle.net/10022/AC:P:14907.

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