Home

Donor age is paramount to success in oocyte donation

Matthew A. Cohen; Steven R. Lindheim; Mark V. Sauer

Title:
Donor age is paramount to success in oocyte donation
Author(s):
Cohen, Matthew A.
Lindheim, Steven R.
Sauer, Mark V.
Date:
Type:
Articles
Department:
Obstetrics and Gynecology
Volume:
14
Permanent URL:
Book/Journal Title:
Human Reproduction
Abstract:
Several reports suggest increasing age in oocyte donors decreases the chances of in-vitro fertilization (IVF) success, while others describe no effect. The published data concerning gravidity and parity are similarly conflicting. To further address these questions, we retrospectively studied 445 consecutive donor IVF cycles at two large university-based IVF practices. Donor cycles were analysed for the number of oocytes retrieved, gravidity, parity, and age of the donor, and pregnancy outcome in recipients. The previous gravidity and parity of the donor were not associated with successful pregnancy in recipients. The number of oocytes retrieved was positively correlated with pregnancy. However, after adjusting for donor age, neither prior fertility nor the number of oocytes retrieved were significant predictors. In contrast, the donor's age was highly associated with recipient success. We conclude that the age of the oocyte donor is a significant predictor of pregnancy success and should be a major factor in selecting prospective candidates. The gravidity and parity of the donor are insignificant predictors, as are the total number of oocytes retrieved at the time of oocyte harvest.
Subject(s):
Obstetrics and gynecology
Publisher DOI:
http://dx.doi.org/10.1093/humrep/14.11.2755
Item views:
56
Metadata:
View

In Partnership with the Center for Digital Research and Scholarship at Columbia University Libraries/Information Services.