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Purkinje cell axonal torpedoes are unrelated to advanced aging and likely reflect cerebellar injury

Elan D. Louis; Phyllis L. Faust; Jean Paul Vonsattel; Cordelia Erickson-Davis

Title:
Purkinje cell axonal torpedoes are unrelated to advanced aging and likely reflect cerebellar injury
Author(s):
Louis, Elan D.
Faust, Phyllis L.
Vonsattel, Jean Paul
Erickson-Davis, Cordelia
Date:
Type:
Articles
Department:
Center for Parkinson's Disease and Other Movement Disorders
Volume:
117
Permanent URL:
Book/Journal Title:
Acta neuropathologica
Abstract:
Torpedoes, swellings of the proximal Purkinje cell axon, are thought to represent a cellular response to injury [3]. They may occur in a variety of cerebellar disorders [7]. Most recently, their numbers were noted to be six-times higher in essential tremor (ET) than control brains [4]. Torpedoes are also often viewed as a cumulative phenomenon associated with advanced aging [3,4], yet there are surprisingly few supporting data. We quantified torpedoes in normal human cerebella spanning a considerable age range to assess whether torpedoes are a cumulative phenomenon of aging. These data help place the relative abundance of torpedoes in ET in context.
Subject(s):
Neurosciences
Publisher DOI:
http://dx.doi.org/10.1007/s00401-009-0534-z
Item views:
298
Metadata:
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