Purkinje cell axonal torpedoes are unrelated to advanced aging and likely reflect cerebellar injury
Elan D. Louis; Phyllis L. Faust; Jean Paul Vonsattel; Cordelia Erickson-Davis
- Purkinje cell axonal torpedoes are unrelated to advanced aging and likely reflect cerebellar injury
Louis, Elan D.
Faust, Phyllis L.
Vonsattel, Jean Paul
- Center for Parkinson's Disease and Other Movement Disorders
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- Acta neuropathologica
- Torpedoes, swellings of the proximal Purkinje cell axon, are thought to represent a cellular response to injury . They may occur in a variety of cerebellar disorders . Most recently, their numbers were noted to be six-times higher in essential tremor (ET) than control brains . Torpedoes are also often viewed as a cumulative phenomenon associated with advanced aging [3,4], yet there are surprisingly few supporting data. We quantified torpedoes in normal human cerebella spanning a considerable age range to assess whether torpedoes are a cumulative phenomenon of aging. These data help place the relative abundance of torpedoes in ET in context.
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