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Ribavirin inhibits West Nile virus replication and cytopathic effect in neural cells

Ingo Jordan; Thomas Briese; Nicole Fischer; Johnson Yiu-Nam Lau; W. Ian Lipkin

Title:
Ribavirin inhibits West Nile virus replication and cytopathic effect in neural cells
Author(s):
Jordan, Ingo
Briese, Thomas
Fischer, Nicole
Lau, Johnson Yiu-Nam
Lipkin, W. Ian
Date:
Type:
Articles
Department:
Center for Infection and Immunity
Volume:
182
Permanent URL:
Book/Journal Title:
Journal of infectious diseases
Abstract:
West Nile virus (WNV) is an emerging mosquito-borne pathogen that was reported for the first time in the Western hemisphere in August 1999, when an encephalitis outbreak in New York City resulted in 62 clinical cases and 7 deaths. WNV, for which no antiviral therapy has been described, was recently recovered from a pool of mosquitoes collected in New York City. In anticipation of the recurrence of WNV during the summer of 2000, an analysis was made of the efficacy of the nucleoside analogue ribavirin, a broad-spectrum antiviral compound with activity against several RNA viruses, for treatment of WNV infection. High doses of ribavirin were found to inhibit WNV replication and cytopathogenicity in human neural cells in vitro.
Subject(s):
Epidemiology
Virology
Publisher DOI:
http://dx.doi.org/10.1086/315847
Item views:
266
Metadata:
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